Oxidative stress, aging, and diseases

Clinical Interventions in Aging, Journal Year: 2018, Volume and Issue: Volume 13, P. 757 - 772

Published: April 1, 2018

Oxidative stress, aging and diseases Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University Naples “Federico II”, Naples, Italy; 2Department Systems Medicine, Rome Tor Vergata, Rome, 3San Raffaele Roma Open University, 4Division Internal AOU San Giovanni di Dio e Ruggi Aragona, Salerno, 5Department Medicine Health Molise, Campobasso, 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Italy Abstract: Reactive oxygen nitrogen species (RONS) are produced by several endogenous exogenous processes, their negative effects neutralized antioxidant defenses. stress occurs from the imbalance between RONS production these Aging is a process characterized progressive loss tissue organ function. The oxidative theory based on hypothesis that age-associated functional losses due to accumulation RONS-induced damages. At same time, involved in age-related conditions (ie, cardiovascular [CVDs], chronic obstructive pulmonary disease, kidney neurodegenerative diseases, cancer), including sarcopenia frailty. Different types biomarkers have been identified may provide important information about efficacy treatment, guiding selection most effective drugs/dose regimens for patients and, if particularly relevant pathophysiological point view, acting specific therapeutic target. Given role pathogenesis many clinical aging, therapy could positively affect natural history but further investigation needed evaluate real interventions. purpose this paper review literature complex topic ever increasing interest. Keywords: elderly, reactive species, antioxidants

Language: Английский

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The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

Nutrition Journal, Journal Year: 2015, Volume and Issue: 15(1)

Published: Dec. 1, 2015

Remarkable interest has risen in the idea that oxidative/nitrosative stress is mediated etiology of numerous human diseases. Oxidative/Nitrosative result an disequilibrium oxidant/antioxidant which reveals from continuous increase Reactive Oxygen and Nitrogen Species production. The aim this review to emphasize with current information importance antioxidants play role cellular responce against stress, would be helpful enhancing knowledge any biochemist, pathophysiologist, or medical personnel regarding important issue. Products lipid peroxidation have commonly been used as biomarkers damage. Lipid generates a variety relatively stable decomposition end products, mainly α, β-unsaturated reactive aldehydes, such malondialdehyde, 4-hydroxy-2-nonenal, 2-propenal (acrolein) isoprostanes, can measured plasma urine indirect index stress. Antioxidants are exogenous endogenous molecules mitigate form its consequences. They may act directly scavenging free radicals increasing antioxidative defences. Antioxidant deficiencies develop decreased antioxidant intake, synthesis enzymes increased utilization. supplementation become increasingly popular practice maintain optimal body function. However, antoxidants exhibit pro-oxidant activity depending on specific set conditions. Of particular their dosage redox conditions cell.

Language: Английский

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Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

Redox Biology, Journal Year: 2017, Volume and Issue: 11, P. 613 - 619

Published: Jan. 5, 2017

Hydrogen peroxide emerged as major redox metabolite operative in sensing, signaling and regulation. Generation, transport capture of H2O2 biological settings well their consequences can now be addressed. The present overview focuses on recent progress metabolic sources sinks the role under physiological conditions (1–10 nM), denoted oxidative eustress. Higher concentrations lead to adaptive stress responses via master switches such Nrf2/Keap1 or NF-κB. Supraphysiological (>100 nM) damage biomolecules, distress. Three questions are addressed: How assayed setting? What H2O2? is stress?

Language: Английский

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Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Circulation Research, Journal Year: 2018, Volume and Issue: 122(6), P. 877 - 902

Published: March 15, 2018

Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes subcellular compartments that typically produce ROS associated with metabolic regulation, diseases dysfunction may be influenced by changes redox balance. In this review, we summarize the current literature surrounding inflammatory focusing on transduction its relationship to disease progression. particular, examine production such as cytoplasm, mitochondria, peroxisome, endoplasmic reticulum discuss how influence processes proteasome function, autophagy, general signaling. We also highlight of regulation metabolic/inflammatory including atherosclerosis, diabetes mellitus, stroke. order develop therapies target oxidative signaling, it is vital understand balance signaling plays physiology pathophysiology, manipulation identity cellular tissue homeostasis. An increased understanding specific sources an appreciation metabolism help guide us effort treat cardiovascular diseases.

Language: Английский

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The Role of Oxidative Stress in Neurodegenerative Diseases

Experimental Neurobiology, Journal Year: 2015, Volume and Issue: 24(4), P. 325 - 340

Published: Dec. 21, 2015

Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction the antioxidant system.The brain one organs especially vulnerable to effects ROS because its high demand and abundance peroxidation-susceptible lipid cells.Previous studies have demonstrated that oxidative plays a central role in common pathophysiology neurodegenerative diseases such as Alzheimer' s disease Parkinson' disease.Antioxidant therapy has been suggested for prevention treatment diseases, although results with regard their efficacy treating inconsistent.In this review, we will discuss vivo measurement index damage stress.Moreover, present knowledge on future directions be outlined.

Language: Английский

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Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 9

Published: Oct. 16, 2018

Aging is the progressive loss of organ and tissue function over time. Growing older positively linked to cognitive biological degeneration such as physical frailty, psychological impairment, decline. Oxidative stress considered an imbalance between pro- antioxidant species, which results in molecular cellular damage. plays a crucial role development age-related diseases. Emerging research evidence has suggested that can control autoxidation by interrupting propagation free radicals or inhibiting formation subsequently reduce oxidative stress, improve immune function, increase healthy longevity. Indeed, oxidation damage highly dependent on inherited acquired defects enzymes involved redox-mediated signaling pathways. Therefore, molecules with activity promote aging counteract worth discuss further. Of particular interest this article, we highlighted mechanisms antioxidants prevention Taken together, better understanding redox modulation inflammation would provide useful approach for potential interventions, promoting

Language: Английский

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Oxidative Stress in Preeclampsia and Placental Diseases

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(5), P. 1496 - 1496

Published: May 17, 2018

Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At cellular level, preeclampsia has largely been associated with release free radicals placenta. Placenta-borne oxidative nitrosative stresses are even sometimes considered as major molecular determinants maternal disease. In this review, we present recent literature evaluating radical production in both normal pathological placentas (including other pregnancy diseases), humans animal models. We then assess putative effects these on placenta endothelium. This analysis was conducted regard to papers possible therapeutic avenues.

Language: Английский

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Reactive Oxygen Species and Mitochondrial Dynamics: The Yin and Yang of Mitochondrial Dysfunction and Cancer Progression

Antioxidants, Journal Year: 2018, Volume and Issue: 7(1), P. 13 - 13

Published: Jan. 16, 2018

Mitochondria are organelles with a highly dynamic ultrastructure maintained by delicate equilibrium between its fission and fusion rates. Understanding the factors influencing this balance is important as perturbations to mitochondrial dynamics can result in pathological states. As terminal site of nutrient oxidation for cell, powerhouses harness energy form ATP process driven electron transport chain. Contemporaneously, electrons translocated within chain undergo spontaneous side reactions oxygen, giving rise superoxide variety other downstream reactive oxygen species (ROS). Mitochondrially-derived ROS mediate redox signaling or, excess, cause cell injury even death. Recent evidence suggests that tightly coupled generation depending on physiological status cell. Yet, mechanism which changes shape modulate function homeostasis less clear. Aberrant morphology may lead enhanced formation, which, turn, deteriorate health further exacerbate oxidative stress self-perpetuating vicious cycle. Here, we review latest findings intricate relationship production, focusing mainly role malignant disease.

Language: Английский

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Antioxidant enzymes regulation in plants in reference to reactive oxygen species (ROS) and reactive nitrogen species (RNS)

Plant Gene, Journal Year: 2019, Volume and Issue: 19, P. 100182 - 100182

Published: April 24, 2019

Language: Английский

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Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

Cell, Journal Year: 2020, Volume and Issue: 181(6), P. 1307 - 1328.e15

Published: June 1, 2020

Language: Английский

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