Molecular Neurobiology,
Journal Year:
2018,
Volume and Issue:
55(10), P. 7987 - 8000
Published: Feb. 28, 2018
The
gut-brain
axis
is
a
bidirectional
communication
network
functionally
linking
the
gut
and
central
nervous
system
(CNS).
Based
on
this,
rational
manipulation
of
intestinal
microbiota
represents
novel
attractive
therapeutic
strategy
for
treatment
CNS-associated
disorders.
In
this
study,
we
explored
properties
probiotic
formulation
(namely
SLAB51)
in
counteracting
brain
oxidative
damages
associated
with
Alzheimer's
disease
(AD).
Specifically,
transgenic
AD
mice
(3xTg-AD)
were
treated
SLAB51
effects
protein
oxidation,
neuronal
antioxidant
defence
repair
systems
monitored,
particular
focus
role
SIRT1-related
pathways.
We
demonstrated
that
markedly
reduced
stress
by
activating
SIRT1-dependent
mechanisms,
thus
representing
promising
adjuvant
treatment.
Frontiers in Aging Neuroscience,
Journal Year:
2016,
Volume and Issue:
8
Published: Nov. 10, 2016
Alzheimer's
disease
(AD)
is
associated
with
severe
cognitive
impairments
as
well
some
metabolic
defects.
Scant
studies
in
animal
models
indicate
a
link
between
probiotics
and
function.
This
randomized,
double-blind
controlled
clinical
trial
was
conducted
among
60
AD
patients
to
assess
the
effects
of
probiotic
supplementation
on
function
status.
The
were
randomly
divided
into
two
groups
(n=30
each
group)
treating
either
milk
(control
or
mixture
(probiotic
group).
supplemented
group
took
200
ml/day
containing
Lactobacillus
acidophilus,
casei,
Bifidobacterium
bifidum
fermentum
(2×109
CFU/g
for
each)
12
weeks.
Mini-mental
state
examination
(MMSE)
score
recorded
all
subjects
before
after
treatment.
Pre-
post-treatment
fasting
blood
samples
obtained
determine
related
markers.
After
weeks
intervention,
compared
control
(-5.03%±3.00),
treated
(+27.90%±8.07)
showed
significant
improvement
MMSE
(P<0.001).
In
addition,
changes
plasma
malondialdehyde
(-22.01%±4.84
vs.
+2.67%±3.86
µmol/L,
P<0.001),
serum
high-sensitivity
C-reactive
protein
(-17.61%±3.70
+45.26%±3.50
µg/mL,
homeostasis
model
assessment-estimated
insulin
resistance
(+28.84%±13.34
vs.+76.95%±24.60,
P=0.002),
Beta
cell
(+3.45%±10.91
+75.62%±23.18,
P=0.001),
triglycerides
(-20.29%±4.49
-0.16%±5.24
mg/dL,
P=0.003)
quantitative
sensitivity
check
index
(-1.83±1.26
-4.66±1.70,
P=0.006)
significantly
varied
group.
We
found
that
treatment
had
no
considerable
effect
other
biomarkers
oxidative
stress
inflammation,
glucose
lipid
profiles.
Overall,
current
study
demonstrated
consumption
positively
affects
statuses
patients.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2017,
Volume and Issue:
2017(1)
Published: Jan. 1, 2017
Increasing
numbers
of
individuals,
particularly
the
elderly,
suffer
from
neurodegenerative
disorders.
These
diseases
are
normally
characterized
by
progressive
loss
neuron
cells
and
compromised
motor
or
cognitive
function.
Previous
studies
have
proposed
that
overproduction
reactive
oxygen
species
(ROS)
may
complex
roles
in
promoting
disease
development.
Research
has
shown
vulnerable
to
oxidative
damage
due
their
high
polyunsaturated
fatty
acid
content
membranes,
consumption,
weak
antioxidant
defense.
However,
exact
molecular
pathogenesis
neurodegeneration
related
disturbance
redox
balance
remains
unclear.
Novel
antioxidants
great
potential
mediating
phenotypes
could
be
an
area
interest
for
further
research.
In
this
review,
we
provide
updated
discussion
on
ROS
pathological
mechanisms
Alzheimer’s
disease,
Huntington’s
Parkinson’s
amyotrophic
lateral
sclerosis,
spinocerebellar
ataxia,
as
well
a
highlight
antioxidant‐based
therapies
alleviating
severity.
Aging and Disease,
Journal Year:
2018,
Volume and Issue:
10(3), P. 637 - 637
Published: Dec. 13, 2018
Oxidative
stress
is
defined
as
an
imbalance
between
production
of
free
radicals
and
reactive
metabolites
or
[reactive
oxygen
species
(ROS)]
their
elimination
by
through
protective
mechanisms,
including
(antioxidants).
This
Such
leads
to
damage
cells
important
biomolecules
cells,
with
hence
posing
a
potential
adverse
impact
on
the
whole
organism.
At
center
day-to-day
biological
response
oxidative
Kelch-like
ECH-associated
protein
1
(Keap1)
-
nuclear
factor
erythroid
2-related
2
(Nrf2)-
antioxidant
elements
(ARE)
pathway,
which
regulates
transcription
many
several
genes
that
preserve
cellular
homeostasis
detoxification
process
eliminate
carcinogens
toxins
before
they
can
cause
damage.
The
redox-sensitive
signaling
system
Keap1/Nrf2/ARE
plays
key
role
in
maintenance
under
stress,
inflammatory,
carcinogenic,
pro-apoptotic
conditions,
allows
us
consider
it
pharmacological
target.
Herein,
we
review
discuss
recent
advancements
regulation
system,
its
physiological
pathophysiological
e.g.
such
exercise,
diabetes,
cardiovascular
diseases,
cancer,
neurodegenerative
disorders,
stroke,
liver
kidney
etc.
such.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(11), P. 5938 - 5938
Published: May 25, 2022
Oxidative
stress
has
been
linked
with
a
variety
of
diseases,
being
involved
in
the
debut
and/or
progress
several
neurodegenerative
disorders.
This
review
intends
to
summarize
some
findings
that
correlate
overproduction
reactive
oxygen
species
pathophysiology
Alzheimer’s
disease,
Parkinson’s
Huntington’s
and
amyotrophic
lateral
sclerosis.
was
also
noted
modify
inflammatory
response.
Even
though
oxidative
neuroinflammation
are
two
totally
different
pathological
events,
they
affect
one
another.
Nonetheless,
there
still
mechanisms
need
be
understood
regarding
onset
diseases
order
develop
efficient
therapies.
As
antioxidants
means
alter
slow
down
symptoms
these
most
common
antioxidants,
enzymatic
as
well
non-enzymatic,
have
mentioned
this
paper
therapeutic
options
for
discussed
Neuroscience Letters,
Journal Year:
2017,
Volume and Issue:
710, P. 132933 - 132933
Published: June 30, 2017
Mitochondria
are
unique
organelles
that
essential
for
a
variety
of
cellular
processes
including
energy
metabolism,
calcium
homeostasis,
lipid
biosynthesis,
and
apoptosis.
Mitochondrial
dysfunction
is
prevalent
feature
many
neurodegenerative
diseases
motor
neuron
disorders
such
as
amyotrophic
lateral
sclerosis
(ALS).
Disruption
mitochondrial
structure,
dynamics,
bioenergetics
buffering
has
been
extensively
reported
in
ALS
patients
model
systems
suggested
to
be
directly
involved
disease
pathogenesis.
Here
we
review
the
alterations
parameters
examine
common
pathways
dysfunction.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2016,
Volume and Issue:
2016(1)
Published: Jan. 1, 2016
Neurodegenerative
diseases
affect
not
only
the
life
quality
of
aging
populations,
but
also
their
spans.
All
forms
neurodegenerative
have
a
massive
impact
on
elderly.
The
major
threat
these
brain
includes
progressive
loss
memory,
Alzheimer's
disease
(AD),
impairments
in
movement,
Parkinson's
(PD),
and
inability
to
walk,
talk,
think,
Huntington's
(HD).
Oxidative
stress
mitochondrial
dysfunction
are
highlighted
as
central
feature
degenerative
diseases.
stress,
condition
that
occurs
due
imbalance
oxidant
antioxidant
status,
has
been
known
play
vital
role
pathophysiology
including
AD,
PD,
HD.
A
large
number
studies
utilized
oxidative
biomarkers
investigate
severity
medications
available,
treat
symptoms.
In
traditional
medicine,
medicinal
plants
used
symptoms
Extensive
scientifically
validated
beneficial
effect
natural
products
against
using
suitable
animal
models.
This
short
review
focuses
pathogenesis
HD
protective
efficacy
Molecular Neurodegeneration,
Journal Year:
2017,
Volume and Issue:
12(1)
Published: Jan. 17, 2017
Oxidative
stress
is
a
common
denominator
in
the
pathology
of
neurodegenerative
disorders
such
as
Alzheimer's
disease,
Parkinson's
Huntington's
amyotrophic
lateral
sclerosis,
and
multiple
well
ischemic
traumatic
brain
injury.
The
highly
vulnerable
to
oxidative
damage
due
its
high
metabolic
demand.
However,
therapies
attempting
scavenge
free
radicals
have
shown
little
success.
By
shifting
focus
inhibit
generation
damaging
radicals,
recent
studies
identified
NADPH
oxidase
major
contributor
disease
pathology.
has
primary
function
generate
radicals.
In
particular,
there
growing
evidence
that
isoforms
NOX1,
NOX2,
NOX4
can
be
upregulated
by
variety
factors.
majority
genetic
pharmacological
inhibition
enzymes
are
neuroprotective
able
reduce
detrimental
aspects
following
injury,
chronic
disorders.
This
review
aims
summarize
supporting
role
these
neurological
disorders,
explores
strategies
targeting
this
pathway,
outlines
obstacles
need
overcome
for
successful
translation
clinic.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2018,
Volume and Issue:
2018(1)
Published: Jan. 1, 2018
A
wide
range
of
neurodegenerative
diseases
(NDs),
including
Alzheimer’s
disease,
Parkinson’s
Huntington’s
and
prion
diseases,
share
common
mechanisms
such
as
neuronal
loss,
apoptosis,
mitochondrial
dysfunction,
oxidative
stress,
inflammation.
Intervention
strategies
using
plant‐derived
bioactive
compounds
have
been
offered
a
form
treatment
for
these
debilitating
conditions,
there
are
currently
no
remedies
to
prevent,
reverse,
or
halt
the
progression
loss.
Rutin,
glycoside
flavonoid
quercetin,
is
found
in
many
plants
fruits,
especially
buckwheat,
apricots,
cherries,
grapes,
grapefruit,
plums,
oranges.
Pharmacological
studies
reported
beneficial
effects
rutin
disease
its
therapeutic
potential
several
models
NDs
has
created
considerable
excitement.
Here,
we
summarized
current
knowledge
on
neuroprotective
various
experimental
NDs.
The
action
reviewed
this
article
include
reduction
proinflammatory
cytokines,
improved
antioxidant
enzyme
activities,
activation
mitogen‐activated
protein
kinase
cascade,
downregulation
mRNA
expression
PD‐linked
proapoptotic
genes,
upregulation
ion
transport
antiapoptotic
restoration
activities
complex
enzymes.
Taken
together,
findings
suggest
that
may
be
promising
compound
