Association between oxidative balance score and risk of postpartum depression in Iranian women: a prospective cohort study DOI Creative Commons
Razieh Tabaeifard, Sara Hashempour,

Maryam Karim Dehnavi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

The oxidative balance score (OBS) serves as a comprehensive measure of exposures related to stress, considering both dietary antioxidants and lifestyle exposures. There is no evidence regarding the relation between OBS postpartum depression (PPD). In this study, we aimed determine relationship during pregnancy PPD. cohort 243 Iranian pregnant women were recruited using convenience sampling method from 2022 2023. Dietary intakes obtained validated food frequency questionnaire. was separately constructed based on nutrients/lifestyle (NLOBS) groups/lifestyle (FLOBS) according previously proposed methods. PPD diagnosed 4 6 weeks after delivery Edinburgh Postpartum Depression Scale. Cox proportional hazards regression utilized examine Participants had mean (SD) age 30.9 ± 6.12 years. total, 43 females with Findings revealed that, controlling all confounders, subjects highest level NLOBS, compared lowest, 69% lower risk (HR: 0.31; 95% CI: 0.12–0.83). Although significant inverse found FLOBS in crude model 0.43; 0.19–0.96); association not fully adjusted 0.53; 0.22–1.27). Considering subtypes each score, relations for NOBS LOBS, but FOBS. This study suggests that higher OBS, particularly nutrient-based may be associated reduced Further research necessary validate these findings.

Language: Английский

High Protein Diet Induces Oxidative Stress in Rat Cerebral Cortex and Hypothalamus DOI Open Access
Ewa Żebrowska, Mateusz Maciejczyk, Małgorzata Żendzian‐Piotrowska

et al.

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(7), P. 1547 - 1547

Published: March 28, 2019

This is the first study to analyze impact of high protein diet (HPD) on antioxidant defense, redox status, as well oxidative damage both a local and systemic level. Male Wistar rats were divided into two equal groups (n = 9): HPD (44% protein) standard (CON; 24.2% protein). After eight weeks, glutathione peroxidase (GPx), reductase (GR), catalase (CAT), superoxide dismutase-1 (SOD-1), reduced (GSH), uric acid (UA), total (TAC)/oxidant status (TOS) advanced glycation end products (AGE), 4-hydroxynonenal (4-HNE), malondialdehyde (MDA) analyzed in serum/plasma, cerebral cortex, hypothalamus CON rats. resulted higher UA concentration activity GPx CAT hypothalamus, whereas cortex these parameters remained unchanged. A significantly lower GSH content was demonstrated plasma when compared Both brain structures expressed 4-HNE MDA, AGE increased only animals. Despite enhancement defense this mechanism does not protect from Hypothalamus more susceptible stress caused by HPD.

Language: Английский

Citations

44
Role of Mesenchymal Stem Cells in Counteracting Oxidative Stress—Related Neurodegeneration DOI Open Access
Cristina Angeloni, Martina Gatti, Cecilia Prata

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(9), P. 3299 - 3299

Published: May 7, 2020

Neurodegenerative diseases include a variety of pathologies such as Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis, and so forth, which share many common characteristics oxidative stress, glycation, abnormal protein deposition, inflammation, progressive neuronal loss. The last century has witnessed significant research to identify mechanisms risk factors contributing the complex etiopathogenesis neurodegenerative diseases, genetic, vascular/metabolic, lifestyle-related factors, often co-occur interact with each other. Apart from several environmental or genetic in recent years, much evidence hints that impairment redox homeostasis is mechanism different neurological diseases. However, pharmacological perspective, stress difficult target, antioxidants, only strategy used far, have been ineffective even provoked side effects. In this review, we report an analysis literature on role well retinal ganglion cells, ataxia. Moreover, contribution stem cells widely explored, looking at their potential differentiation reporting findings application fighting particular, exposure mesenchymal secretome can be considered promising therapeutic enhance antioxidant capacity neurotrophin expression while inhibiting pro-inflammatory cytokine secretion, are aspects pathologies. Further studies needed tailored approach for disease order design more effective cell strategies prevent broad range disorders.

Language: Английский

Citations

40
Salivary Biomarkers of Oxidative Stress and Inflammation in Stroke Patients: From Basic Research to Clinical Practice DOI Creative Commons
Mateusz Maciejczyk, Marzena Bielas, Anna Zalewska

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Cerebral stroke is a serious worldwide health problem, as can be seen by the global epidemic of disease. In this disorder, when blood flow compromised ruptures or blocked arteries, sudden death neurons observed result lack oxygen and nutrients. Numerous severe problems frequent complications also exist in patients; therefore, there an urgent need to develop new therapeutic, diagnostic, prognostic methods for At present, diagnosis based on neurological examination, medical history, neuroimaging, due fact that rapid noninvasive diagnostic tests are unavailable. Nevertheless, oxidative stress inflammation considered key factors pathogenesis. Oxygen free radicals responsible oxidation lipids, proteins, DNA/RNA, which turn contributes damage brain. Toxic products reactions act cytostatically cell damaging membranes leading neuronal apoptosis necrosis. Thus, it seems redox/inflammatory biomarkers might used Nowadays, saliva increasing interest clinical laboratory medicine. Redox could obtained easily, noninvasively, cheaply, stress‐free from saliva. This minireview aimed at presenting current knowledge concerning use salivary prognosis stroke.

Language: Английский

Citations

38
The role of mitochondrial dynamics imbalance in hexavalent chromium-induced apoptosis and autophagy in rat testis DOI
Ruonan Wang, Yuxiang Huang, Lu Yu

et al.

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 374, P. 110424 - 110424

Published: Feb. 26, 2023

Language: Английский

Citations

13
Association between oxidative balance score and risk of postpartum depression in Iranian women: a prospective cohort study DOI Creative Commons
Razieh Tabaeifard, Sara Hashempour,

Maryam Karim Dehnavi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

The oxidative balance score (OBS) serves as a comprehensive measure of exposures related to stress, considering both dietary antioxidants and lifestyle exposures. There is no evidence regarding the relation between OBS postpartum depression (PPD). In this study, we aimed determine relationship during pregnancy PPD. cohort 243 Iranian pregnant women were recruited using convenience sampling method from 2022 2023. Dietary intakes obtained validated food frequency questionnaire. was separately constructed based on nutrients/lifestyle (NLOBS) groups/lifestyle (FLOBS) according previously proposed methods. PPD diagnosed 4 6 weeks after delivery Edinburgh Postpartum Depression Scale. Cox proportional hazards regression utilized examine Participants had mean (SD) age 30.9 ± 6.12 years. total, 43 females with Findings revealed that, controlling all confounders, subjects highest level NLOBS, compared lowest, 69% lower risk (HR: 0.31; 95% CI: 0.12–0.83). Although significant inverse found FLOBS in crude model 0.43; 0.19–0.96); association not fully adjusted 0.53; 0.22–1.27). Considering subtypes each score, relations for NOBS LOBS, but FOBS. This study suggests that higher OBS, particularly nutrient-based may be associated reduced Further research necessary validate these findings.

Language: Английский

Citations

0