Free Radical Biology and Medicine, Journal Year: 2020, Volume and Issue: 158, P. 44 - 52
Published: July 17, 2020
Language: Английский
Nanoscale, Journal Year: 2024, Volume and Issue: 16(9), P. 4434 - 4483
Published: Jan. 1, 2024
Metal-organic frameworks have become promising stimuli-responsive agents to release the loaded therapeutic in target site achieve more precise drug delivery due their high loading, excellent biocompatibility, and stimuli-responsiveness.
Language: Английский
Citations
31
Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 138 - 138
Published: Jan. 11, 2024
A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, in contemporary society, there a prevalent occurrence misalignments system environmental cues, phenomenon frequently associated with adverse health consequences. The onset most current chronic diseases intimately connected alterations lifestyle practices under various facets, including following: reduced physical activity, exposure artificial light, also acknowledged as light pollution, sedentary behavior coupled consuming energy-dense nutriments, irregular eating frameworks, disruptions sleep patterns (inadequate quality duration), engagement shift work, known jetlag. rapid evolution life domestic routines has significantly outpaced rate genetic adaptation. Consequently, underlying rhythms exposed multiple shifts, thereby elevating susceptibility disease predisposition. comprehensive review endeavors synthesize existing empirical evidence that substantiates conceptual integration clock, biochemical molecular homeostasis, oxidative stress, stimuli imparted exercise, sleep, nutrition.
Language: Английский
Citations
17
Antioxidants, Journal Year: 2019, Volume and Issue: 8(6), P. 196 - 196
Published: June 25, 2019
Nuclear factor erythroid 2-related 2 (Nrf2) is a powerful nuclear transcription that coordinates an antioxidant cytoprotector system complex stimulated by the increase in inoxidative stress (OS). In present manuscript, we conduct review on evidence shows effect different modalities of physical exercise exert metabolic response directed Nrf2. During exercise, reactive oxygen species (ROS) are increased; therefore, if endogenous and exogenous defenses unable to control elevation ROS, resulting OS triggers activation transcriptional Nrf2 induce response. On molecular basis related hormesis maintenance (exercise preconditioning) adaptative changes training supported growing body evidence, which important for detailing health benefits involve greater resistance environmental aggressions, better tolerance constant changes, increasing regenerative capacity cells such way it may be used as tool support prevention or treatment diseases. This have clinical implications future investigations regarding terms understanding adaptations high-performance athletes but also therapeutic model several
Language: Английский
Citations
126
Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 4430 - 4446
Published: May 4, 2021
In the recent decades, zinc (Zn) and its alloys have been drawing attention as promising candidates for bioresorbable cardiovascular stents due to degradation rate more suitable than magnesium (Mg) iron (Fe) alloys. However, mechanical properties need be improved in order meet criteria vascular stents. This work investigates properties, biodegradability biocompatibility of Zn-Mg Zn-Cu determine a proper alloy composition optimal stent performance. Nanoindentation measurements are performed characterize at nanoscale function Zn microstructure variations induced by alloying. The biodegradation mechanisms discussed correlated microstructure, performance bacterial/cell response. Addition Mg or Cu alloying elements refined enhanced yield strength (YS) ultimate tensile (UTS) proportional volume fraction secondary phases. Zn-1Mg showed higher YS UTS better terms stability Hanks' solution. presented an antibacterial effect S. aureus controlled diffusion contact. Biocompatibility was dependent on nature corrosion products.
Language: Английский
Citations
100
Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1050 - 1050
Published: May 5, 2023
In recent years, microalgae have become a source of molecules for healthy life. Their composition carbohydrates, peptides, lipids, vitamins and carotenoids makes them promising new antioxidant molecules. Skeletal muscle is tissue that requires constant remodeling via protein turnover, its regular functioning consumes energy in the form adenosine triphosphate (ATP), which produced by mitochondria. Under conditions traumatic exercise or muscular diseases, high production reactive oxygen species (ROS) at origin oxidative stress (OS) will lead to inflammation atrophy, with life-long consequences. this review, we describe potential effects their biomolecules on mitochondrial functions skeletal during exercises musculoskeletal as sarcopenia, chronic obstructive pulmonary disease (COPD) Duchenne dystrophy (DMD), through increase regulation pathways synthesis.
Language: Английский
Citations
30
Nutrients, Journal Year: 2020, Volume and Issue: 12(11), P. 3473 - 3473
Published: Nov. 12, 2020
The primary variables influencing the adaptive response to a bout of endurance training are exercise duration and intensity. However, altering availability nutrients before during can also impact by modulating stimulus and/or physiological molecular responses exercise-induced perturbations. purpose this review is highlight current knowledge influence pre-exercise nutrition ingestion on metabolic, physiological, performance suggest directions for future research. Acutely, carbohydrate reduces fat oxidation, but there little evidence showing enhanced burning capacity following long-term fasted-state training. Performance improved longer not shorter exercise, while training-induced improvements strategies that modulate vary based type protocol used. Contrasting findings related acute mitochondrial signaling may be amount consumed intensity exercise. This help guide athletes, coaches, nutritionists in personalizing strategies, designing research studies further elucidate role adaptations.
Language: Английский
Citations
55
Redox Biology, Journal Year: 2021, Volume and Issue: 43, P. 101976 - 101976
Published: April 23, 2021
Mitochondria are central regulators of cellular metabolism, most known for their role in energy production. They can be "enhanced" by physical activity (including exercise), which increases integrity, efficiency and dynamic adaptation to stressors, short "mitochondrial fitness". Mitochondrial fitness is closely associated with cardiorespiratory activity. Given the importance mitochondria immune functions, it thus not surprising that also an integral determinant antiviral host defense vulnerability infection. Here, we first briefly review viral infections. We then summarize mitochondrial functions relevant response a particular focus on current Coronavirus Disease (COVID-19) pandemic innate function. Finally, modulation activity, aging chronic diseases represent common comorbidities COVID-19 discussed. conclude high - related should considered as protective factors infections, including COVID-19. This assumption corroborated reduced many established risk COVID-19, like age, various or obesity. argue regular analysis patients promotion – all its health benefits preventive measures against
Language: Английский
Citations
54
Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9
Published: Dec. 14, 2022
Arthrospira platensis, also known as spirulina, is currently one of the most well-known algae supplements, mainly due to its high content bioactive compounds that may promote human health. Some authors have hypothesized spirulina consumption could protect subjects from exercise-induced oxidative stress, accelerate recovery by reducing muscle damage, and stimulate immune system. Based on this, main goal this review was critically analyze effects system, inflammation performance in athletes people undergoing exercise interventions. Of 981 articles found, 428 studies were considered eligible 13 met established criteria included systematic review. Most recently supplementation has demonstrated ergogenic potential during submaximal exercise, increasing oxygen uptake improving tolerance. Nevertheless, does not seem enhance physical power athletes. Considering data supporting benefits system still lacking, overall evidence regarding benefit healthy engaged scarce consistent. Currently, might be who do meet recommended dietary intake antioxidants. Further high-quality research needed evaluate performance, active people.[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=262896], identifier [CRD42021262896].
Language: Английский
Citations
32
Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 256 - 256
Published: Jan. 28, 2022
Compelling research has documented how the circadian system is essential for maintenance of several key biological processes including homeostasis, cardiovascular control, and glucose metabolism. Circadian clock disruptions, or losses rhythmicity, have been implicated in development diseases, premature ageing, are regarded as health risks. Redox reactions involving reactive oxygen nitrogen species (RONS) regulate physiological functions such cell signalling immune response. However, oxidative stress associated with pathological effects RONS, resulting a loss damaging modifications to important molecules DNA. Direct connections established between rhythms on basis that disruptions can affect redox biology, vice versa, bi-directional relationship. For instance, expression activity antioxidant enzymes (SOD, GPx, CAT) appear follow patterns. Consequently, ability unravel these interactions opened an exciting area biology. Exercise exerts numerous benefits and, potent environmental cue, capacity adjust disrupted systems. In fact, response given exercise stimulus may also exhibit variation. At same time, relationship exercise, scrutinised, whereby it clear exercise-induced RONS elicit both helpful potentially harmful dependent type, intensity, duration exercise. To date, appears emerging interface rhythmicity stress/redox metabolism not explored relation This review aims summarise evidence supporting conceptual link clock, stimuli. We believe carefully designed investigations this nexus required, which could be harnessed tackle theories concerned with, example, existence optimal time accrue benefits.
Language: Английский
Citations
27
Trends in Endocrinology and Metabolism, Journal Year: 2023, Volume and Issue: 34(9), P. 503 - 504
Published: June 24, 2023
Language: Английский
Citations
14