Journal of sport and health science/Journal of Sport and Health Science,
Journal Year:
2020,
Volume and Issue:
9(5), P. 415 - 425
Published: May 4, 2020
The
first
report
demonstrating
that
prolonged
endurance
exercise
promotes
oxidative
stress
in
humans
was
published
more
than
4
decades
ago.
Since
this
discovery,
many
ensuing
investigations
have
corroborated
the
fact
muscular
increases
production
of
reactive
oxygen
species
(ROS)
and
results
numerous
tissues
including
blood
skeletal
muscles.
Although
several
may
contribute
to
exercise-induced
ROS
production,
it
is
predicted
contractions
stimulate
active
muscle
fibers
a
primary
source
during
exercise.
This
contraction-induced
generation
associated
with
(1)
oxidant
damage
(e.g.,
increased
protein
oxidation
lipid
peroxidation),
(2)
accelerated
fatigue,
(3)
activation
biochemical
signaling
pathways
adaptation
contracting
fibers.
While
our
understanding
has
advanced
rapidly
last
decades,
questions
remain
about
whether
are
beneficial
or
harmful
health.
review
addresses
issue
by
discussing
site(s)
detailing
health
consequences
production.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1098 - 1098
Published: Jan. 27, 2025
This
article
reviews
the
synergistic
effects
of
antioxidant-enriched
functional
foods
and
exercise
in
improving
metabolic
health,
focusing
on
underlying
molecular
mechanisms.
The
review
incorporates
evidence
from
PubMed,
SCOPUS,
Web
Science,
PsycINFO,
reference
lists
relevant
up
to
20
December
2024,
highlighting
central
role
Nrf2
pathway.
As
a
critical
regulator
oxidative
stress
adaptation,
mediates
benefits
these
interventions.
presents
an
innovative
approach
understanding
regulation
inflammation,
its
potential
prevention
treatment
various
diseases,
including
cancer,
neurodegenerative
disorders,
cardiovascular
pulmonary
diabetes,
inflammatory
conditions,
ageing,
infections
such
as
COVID-19.
novelty
this
study
is
investigate
bioactive
compounds
found
(such
polyphenols,
flavonoids,
vitamins)
exercise-induced
activation
combined
reveals
their
improve
insulin
sensitivity
lipid
metabolism
reduce
offering
promising
strategy
for
management
chronic
diseases.
However,
there
are
significant
gaps
current
research,
particularly
regarding
mechanisms
interaction
between
diet,
physical
activity,
activation,
well
long-term
different
populations,
those
with
In
addition,
interactions
other
signalling
pathways,
AMPK,
NF-κB,
PI3K/Akt,
collective
contributions
health
explored.
Furthermore,
novel
biomarkers
presented
assess
impact
strategies,
NAD+/NADH
ratio,
GSH
markers
mitochondrial
health.
findings
provide
valuable
insights
into
how
integration
antioxidant-rich
diet
regular
can
by
activating
related
pathways
represent
strategies
disorders.
Further
studies
needed
fully
understand
therapeutic
interventions
diseases
stress,
disease,
cancer.
Redox Biology,
Journal Year:
2020,
Volume and Issue:
35, P. 101499 - 101499
Published: March 10, 2020
Redox
reactions
control
fundamental
processes
of
human
biology.
Therefore,
it
is
safe
to
assume
that
the
responses
and
adaptations
exercise
are,
at
least
in
part,
mediated
by
redox
reactions.
In
this
review,
we
are
trying
show
basis
physiology
outlining
signaling
pathways
regulate
four
characteristic
acute
exercise-induced
(muscle
contractile
function,
glucose
uptake,
blood
flow
bioenergetics)
chronic
(mitochondrial
biogenesis,
muscle
hypertrophy,
angiogenesis
homeostasis).
Based
on
our
analysis,
argue
regulation
should
be
acknowledged
as
central
physiology.
Cells,
Journal Year:
2021,
Volume and Issue:
10(11), P. 2974 - 2974
Published: Nov. 1, 2021
Aging
is
the
result
of
deterioration
homeostatic
systems
(nervous,
endocrine,
and
immune
systems),
which
preserve
organism’s
health.
We
propose
that
age-related
impairment
these
due
to
establishment
a
chronic
oxidative
stress
situation
leads
low-grade
inflammation
throughout
system’s
activity.
It
known
system
weakens
with
age,
increases
morbidity
mortality.
In
this
context,
we
describe
how
function
cells
can
be
used
as
an
indicator
rate
aging
individual.
addition
passive
role
marker,
work
driver
by
amplifying
oxidative-inflammatory
associated
(oxi-inflamm-aging)
inducing
senescence
in
far
tissue
cells.
Further
supporting
our
theory,
discuss
certain
lifestyle
conditions
(such
social
environment,
nutrition,
or
exercise)
have
impact
on
longevity
affecting
inflammatory
state
cells,
regulating
immunosenescence
its
contribution
oxi-inflamm-aging.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(6), P. 1936 - 1936
Published: March 12, 2020
In
recent
years,
epidemiological
studies
have
shown
that
food
is
a
very
powerful
means
for
maintaining
state
of
well-being
and
health
prevention.
Many
degenerative,
autoimmune
neoplastic
diseases
are
related
to
nutrition
the
nutrient–organism
interaction
could
define
balance
between
disease.
Nutrients
dietary
components
influence
epigenetic
phenomena
modify
drugs
response;
therefore,
these
food–host
interactions
can
individual
predisposition
disease
its
potential
therapeutic
response.
Do
nutraceuticals
positive
or
negative
effects
during
chemotherapy?
The
use
nutraceutical
supplements
in
cancer
patients
controversial
debate
without
definitive
conclusion
date.
During
treatment,
take
alleviate
drug
toxicity
improve
long-term
results.
Some
may
potentiate
effect
cytotoxic
chemotherapy
by
inducing
cell
growth
arrest,
differentiation,
alteration
redox
cells,
but
some
cases,
high
levels
them
interfere
with
effectiveness
chemotherapy,
making
cells
less
reactive
chemotherapy.
this
review,
we
highlighted
emerging
opinions
data
on
pros
cons
Biomedicines,
Journal Year:
2020,
Volume and Issue:
8(10), P. 406 - 406
Published: Oct. 12, 2020
Worldwide,
over
2.2
million
people
suffer
from
multiple
sclerosis
(MS),
a
multifactorial
demyelinating
disease
of
the
central
nervous
system.
MS
is
characterized
by
wide
range
motor,
autonomic,
and
psychobehavioral
symptoms,
including
depression,
anxiety,
dementia.
The
blood,
cerebrospinal
fluid,
postmortem
brain
samples
patients
provide
evidence
on
disturbance
reduction-oxidation
(redox)
homeostasis,
such
as
alterations
oxidative
antioxidative
enzyme
activities
presence
degradation
products.
This
review
article
discusses
components
redox
reactive
chemical
species,
enzymes,
species
cover
frequently
discussed
oxygen/nitrogen
infrequently
featured
chemicals
sulfur,
carbonyl,
halogen,
selenium,
nucleophilic
that
potentially
act
reductive,
well
pro-oxidative
stressors.
systems
nuclear
factor
erythroid-2-related
2
(NRF2)-Kelch-like
ECH-associated
protein
1
(KEAP1)
signaling
pathway.
NRF2
other
transcriptional
factors
become
biomarker
sensitive
to
initial
phase
stress.
Altered
homeostasis
in
were
search
diagnostic,
prognostic,
predictive,
and/or
therapeutic
biomarker.
Finally,
monitoring
battery
products
helps
evaluate
status
expedite
building
personalized
treatment
plans
for
sake
better
quality
life.
Free Radical Research,
Journal Year:
2020,
Volume and Issue:
55(4), P. 321 - 330
Published: Dec. 11, 2020
Carnosine
is
an
endogenous
dipeptide
whose
oral
administration
has
been
found
to
prevent
several
oxidative
based
diseases
including
lung
disease,
type
2
diabetes
and
its
micro
macrovascular
complications,
cardiovascular
disorders,
neurodegenerative
kidney
disease.
While
it
generally
accepted
that
the
beneficial
effects
of
carnosine
are
due
antioxidant,
anti-advanced
glycation
end
product
(AGE)
-advanced
lipoxidation
(ALE)
anti-inflammatory
properties,
molecular
mechanisms
explaining
such
have
not
yet
clearly
defined.
Studies
indicate
acts
by
a
direct
antioxidant
mechanism
sequestering
reactive
carbonyls
(RCS),
byproducts
lipid
glucose
oxidation,
thus
inhibiting
AGE
ALE
which
reaction
products
RCS
with
proteins.
Moreover,
also
act
indirectly
activating
Nrf2
transcription
factor,
would
explain
many
evoked
this
peptide
as
anti-inflammatory,
antiglycation
anti-carbonyl
taken
together
therapeutic
effect.
The
present
review
reports
discusses
most
recent
studies
on
need
be
fully
clarified
before
promoting
derivatives
agents.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(19), P. 7053 - 7053
Published: Sept. 25, 2020
The
exposure
of
living
organisms
to
environmental
stress
triggers
defensive
responses
resulting
in
the
activation
protective
processes.
Whenever
occurs
at
low
doses,
effects
overwhelm
adverse
exposure;
this
adaptive
situation
is
referred
as
"hormesis".
Environmental,
physical,
and
nutritional
hormetins
lead
stimulation
strengthening
maintenance
repair
systems
cells
tissues.
Exercise,
heat,
irradiation
are
examples
physical
hormetins,
which
activate
heat
shock-,
DNA
repair-,
anti-oxidative-stress
responses.
health
promoting
effect
many
bio-actives
fruits
vegetables
can
be
seen
mildly
toxic
compounds
triggering
stimulus.
Numerous
studies
indicate
that
possess
ability
adapt
conditions,
exemplified
by
fact
damage
gene
expression
profiling
populations
environment
with
high
levels
air
pollution
do
not
correspond
concentrations
pollutants.
molecular
mechanisms
hormetic
response
include
modulation
(a)
transcription
factor
Nrf2
activating
synthesis
glutathione
subsequent
protection
cell;
(b)
methylation;
(c)
microRNA.
These
findings
provide
evidence
hormesis
a
toxicological
event,
occurring
doses
stressors,
having
benefit
for
healthy
status.
Biomolecules,
Journal Year:
2021,
Volume and Issue:
11(3), P. 437 - 437
Published: March 16, 2021
Amyotrophic
lateral
sclerosis
(ALS)
affects
motor
neurons
in
the
cerebral
cortex,
brainstem
and
spinal
cord
leads
to
death
due
respiratory
failure
within
three
five
years.
Although
clinical
symptoms
of
this
disease
were
first
described
1869
it
is
most
common
neuron
neurodegenerative
middle-aged
individuals,
exact
etiopathogenesis
ALS
remains
unclear
incurable.
However,
free
oxygen
radicals
(i.e.,
molecules
containing
one
or
more
electrons)
are
known
contribute
pathogenesis
as
they
very
readily
bind
intracellular
structures,
leading
functional
impairment.
Antioxidant
enzymes,
which
often
metalloenzymes,
inactivate
by
converting
them
into
a
less
harmful
substance.
One
important
antioxidant
enzymes
Cu2+Zn2+
superoxide
dismutase
(SOD1),
mutated
20%
cases
familial
form
(fALS)
up
7%
sporadic
(sALS)
cases.
In
addition,
proper
functioning
catalase
glutathione
peroxidase
(GPx)
essential
for
protection.
review
article,
we
focus
on
mechanisms
through
these
involved
response
oxidative
stress
thus
their
potential
therapeutic
targets.
