Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 215, P. 115707 - 115707
Published: July 26, 2023
Language: Английский
Redox Biology, Journal Year: 2021, Volume and Issue: 41, P. 101867 - 101867
Published: Jan. 20, 2021
In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as eustress, which operates within physiological range that has been called 'Homeodynamic Space', 'Goldilocks Zone' or 'Golden Mean'. Spatiotemporal control achieved by compartmentalized generation removal oxidants. cellular landscape H2O2, major molecule, characterized orders-of-magnitude concentration differences between organelles. This pattern mirrored oxidatively modified proteins, exemplified S-glutathionylated proteins. review presents conceptual background for short-term (non-transcriptional) longer-term (transcriptional/translational) homeostatic mechanisms stress responses. point variable moving target value, modulated circadian rhythm external influence, summarily exposome, includes nutrition lifestyle factors. Emerging fields cell-specific tissue-specific regulation in settings are briefly presented, including new insight into role eustress embryonal development lifespan, skeletal muscle exercise, sleep-wake rhythm, function nervous system with aspects leading to psychobiology.
Language: Английский
Citations
228
Bioactive Materials, Journal Year: 2021, Volume and Issue: 7, P. 47 - 72
Published: June 20, 2021
Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction, but morbidity and mortality of infarction still high. Reperfusion injuries inevitable due the generation reactive oxygen species (ROS) apoptosis cardiac muscle cells. However, many antioxidant anti-inflammatory drugs largely limited by pharmacokinetics route administration, such as short half-life, low stability, bioavailability, side effects for treatment ischemia injury. Therefore, it is necessary develop effective technologies address this issue. Fortunately, nanotherapies have demonstrated great opportunities treating Compared with traditional drugs, nanodrugs can effectively increase therapeutic effect reduces improving pharmacokinetic pharmacodynamic properties nanodrugs' size, shape, material characteristics. In review, biology ROS molecular mechanisms injury discussed. Furthermore, we summarized applications ROS-based nanoparticles, highlighting latest achievements nanotechnology researches
Language: Английский
Citations
223
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Aug. 23, 2024
Abstract Alzheimer’s disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. Its etiology is intricate diverse, stemming from a combination factors such aging, genetics, environment. Our current understanding AD pathologies involves various hypotheses, cholinergic, amyloid, tau protein, inflammatory, oxidative stress, metal ion, glutamate excitotoxicity, microbiota-gut-brain axis, abnormal autophagy. Nonetheless, unraveling interplay among these pathological aspects pinpointing primary initiators require further elucidation validation. In past decades, most clinical drugs have been discontinued due to limited effectiveness or adverse effects. Presently, available primarily offer symptomatic relief often accompanied by undesirable side However, recent approvals aducanumab ( 1 ) lecanemab 2 Food Drug Administration (FDA) present potential in disrease-modifying Nevertheless, long-term efficacy safety need Consequently, quest for safer more effective persists formidable pressing task. This review discusses pathogenesis, advances diagnostic biomarkers, latest updates trials, emerging technologies drug development. We highlight progress discovery selective inhibitors, dual-target allosteric modulators, covalent proteolysis-targeting chimeras (PROTACs), protein-protein interaction (PPI) modulators. goal provide insights into prospective development application novel drugs.
Language: Английский
Citations
184
Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 417, P. 126025 - 126025
Published: May 15, 2021
Language: Английский
Citations
142
Redox Biology, Journal Year: 2021, Volume and Issue: 42, P. 101887 - 101887
Published: Feb. 6, 2021
"Life is an instantaneous encounter of circulating matter and flowing energy" (Jean Giaja, Serbian physiologist), one the most elegant definitions not only life but relationship redox biology metabolism. Their evolutionary liaison has created inseparable yet dynamic homeostasis in health, which, when disrupted, leads to disease. This interconnection even more pertinent today, era increasing metabolic diseases epidemic proportions such as obesity, syndrome, diabetes. Despite great advances understanding molecular mechanisms regulation, we face significant challenges preventing, diagnosing, treating diseases. The etiological association temporal overlap these syndromes present for discrimination appropriate clinical biomarkers diagnosis, treatment, outcome prediction. These multifactorial, multiorgan with complex etiopathogenic are accompanied by disturbed equilibrium target tissues circulation. Free radicals reactive species considered both a causal factor consequence disease status. Thus, determining subtypes levels free species, oxidatively damaged biomolecules (lipids, proteins, nucleic acids) antioxidant defense components well redox-sensitive transcription factors fluxes redox-dependent pathways will help define existing establish novel stratifying review aims discuss diverse redox/metabolic aspects diabetes, imperative platform emerging future redox-metabolic research precision medicine. Future warrants detailed investigations into status healthy subjects patients, including use 'omic' profiling technologies (e.g., proteomes, lipidomes, metabolomes, transcriptomes), taking account influence lifestyle (diet, physical activity, sleep, work patterns) circadian ~24h fluctuations circulatory metabolites.
Language: Английский
Citations
107
BioMed Research International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 12
Published: Sept. 17, 2022
Oxidative stress is an imbalance between free radicals and the antioxidant system causing overgeneration of (oxygen-containing molecules) ultimately leading to oxidative damage in terms lipid peroxidation, protein denaturation, DNA mutation. can activate autophagy alleviate maintain normal physiological activities cells by degrading damaged organelles or local cytoplasm. When not eliminated autophagy, it activates apoptosis cascade. This review provides a brief summary mitochondrial-endoplasmic reticulum communication-mediated autophagy. Mitochondria endoplasmic being important are directly indirectly connected each other through mitochondria-associated membranes jointly regulate The reactive oxygen species (ROS) produced mitochondrial respiratory chain main inducers stress. Damaged mitochondria be effectively cleared process mitophagy mediated PINK1/parkin pathway, Nix/BNIP3 pathways, FUNDC1 avoiding excessive ROS production. However, mechanism communication regulation rarely known. For this reason, explores mutual connection mediating Ca
Language: Английский
Citations
77
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117084 - 117084
Published: Aug. 1, 2024
The accumulation of excess reactive oxygen species (ROS) can lead to oxidative stress (OS), which induce gene mutations, protein denaturation, and lipid peroxidation directly or indirectly. expression is reduced ATP level in cells, increased cytoplasmic Ca
Language: Английский
Citations
53
ACS Nano, Journal Year: 2023, Volume and Issue: 17(17), P. 16573 - 16586
Published: Aug. 14, 2023
An essential challenge in diabetic periodontal regeneration is achieving the transition from a hyperglycemic inflammatory microenvironment to regenerative one. Here, we describe polydopamine (PDA)-mediated ultralong silk microfiber (PDA-mSF) and metformin (Met)-loaded zeolitic imidazolate framework (ZIF) incorporated into fibroin/gelatin (SG) patch promote soft hard tissue by regulating immunomodulatory microenvironment. The PDA-mSF endows with reactive oxygen species (ROS)-scavenging ability anti-inflammatory activity, reducing response suppressing M1 macrophage polarization. Moreover, PDA improves ligament reconstruction via its cell affinity. Sustained release of Met Met-ZIF system confers antiaging abilities activating M2 polarization secrete osteogenesis-related cytokines, while Zn2+ also promotes bone regeneration. Consequently, creates favorable for These features synergistically accelerate Thus, our findings offer potential therapeutic strategy periodontitis.
Language: Английский
Citations
52
Environmental Research, Journal Year: 2024, Volume and Issue: 250, P. 118485 - 118485
Published: Feb. 17, 2024
Language: Английский
Citations
45
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)
Published: Jan. 15, 2024
Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.
Language: Английский
Citations
32