The role of ROS in tumour development and progression

Nature reviews. Cancer, Journal Year: 2022, Volume and Issue: 22(5), P. 280 - 297

Published: Jan. 31, 2022

Language: Английский

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Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Jan. 16, 2023

Abstract Microorganisms, including bacteria, viruses, fungi, and other eukaryotes, play critical roles in human health. An altered microbiome can be associated with complex diseases. Intratumoral microbial components are found multiple tumor tissues closely correlated cancer initiation development therapy efficacy. The intratumoral microbiota may contribute to promotion of the progression cancers by DNA mutations, activating carcinogenic pathways, promoting chronic inflammation, complement system, initiating metastasis. Moreover, not only enhance antitumor immunity via mechanisms STING signaling activation, T NK cell TLS production, microbiota-derived antigen presenting, but also decrease immune responses promote through pathways upregulation ROS, an anti-inflammatory environment, inactivation, immunosuppression. effect on is dependent composition, crosstalk between cancer, status cancers. regulate physiology response different β-catenin, TLR, ERK, NF-κB, STING, among others. These viewpoints help identify as diagnosis or prognosis evaluation cancers, new therapeutic strategy potential targets for therapy.

Language: Английский

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Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

Journal of Biomedical Science, Journal Year: 2022, Volume and Issue: 29(1)

Published: Sept. 26, 2022

The major concept of "oxidative stress" is an excess elevated level reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption oxygen. precise harmonization oxidative stresses between mitochondria other organelles in the cell absolutely vital to survival. Under stress, ROS produced mediator for tumorigenesis different aspects, such as proliferation, migration/invasion, angiogenesis, inflammation, immunoescape allow cancer cells adapt rigorous environment. Accordingly, dynamic balance not only orchestrate complex signaling events but also affect components tumor microenvironment (TME). Immune cells, M2 macrophages, dendritic T immunosuppressive TME ROS-induced inflammation. Based on this notion, numerous strategies mitigate tumors have been tested prevention or therapies; however, these manipulations devised sources mechanisms without established effectiveness. Herein, we integrate current progress regarding impact mitochondrial TME, immune discuss combination emerging ROS-modulating with immunotherapies achieve antitumor effects.

Language: Английский

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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662

Published: July 30, 2023

Language: Английский

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Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Aug. 10, 2023

Abstract The reversible oxidation-reduction homeostasis mechanism functions as a specific signal transduction system, eliciting related physiological responses. Disruptions to redox can have negative consequences, including the potential for cancer development and progression, which are closely linked series of processes, such adjustment reactive oxygen species (ROS) levels species, changes in antioxidant capacity, differential effects ROS on downstream cell fate immune capacity. tumor microenvironment (TME) exhibits complex interplay between immunity regulatory death, especially autophagy apoptosis, is crucially regulated by ROS. present study aims investigate multi-source affects autophagy, anti-tumor response TME mutual crosstalk these three processes. Given intricate role controlling immunity, we will further examine relationship traditional therapy It worth noting that discuss some ROS-related treatment options future studies.

Language: Английский

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Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: June 11, 2024

Abstract Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as tumour-associated macrophages (TAMs). These specialized immune cells play crucial roles growth, angiogenesis, regulation, metastasis, and chemoresistance. TAMs encompass various subpopulations, primarily classified into M1 M2 subtypes based on their differentiation activities. macrophages, characterized by a pro-inflammatory phenotype, exert anti-tumoural effects, while with an anti-inflammatory function protumoural regulators. highly versatile respond to stimuli from other constituents within (TME), such growth factors, cytokines, chemokines, enzymes. induce polarization towards one phenotype another, leading complex interactions TME components influencing both pro-tumour anti-tumour processes. This review comprehensively deeply covers literature origin well intricate interplay between TME, dual nature promoting pro- Moreover, delves primary pathways implicated macrophage polarization, examining diverse that regulate this process. role shaping functions macrophages. In addition, advantages limitations current clinical interventions reviewed, including enhancing TAM phagocytosis, inducing exhaustion, inhibiting recruitment, polarizing M1-like phenotype. conclusion, treatment strategies targeting precision medicine show promise, overcoming several obstacles is still necessary achieve accessible efficient immunotherapy.

Language: Английский

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Recent advances in photo‐responsive carbon dots for tumor therapy

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2)

Published: May 1, 2024

Abstract The precision treatment of tumors with minimal side effects is associated improved human health and quality life. In recent years, phototherapy has attracted significant attention in tumor therapy due to its versatility, spatiotemporal controllability, non‐resistance, effects. Carbon dots (CDs) are considered promising reagents because their simple preparation, facilitated surface modification, tunable energy bands, excellent electron‐transfer capabilities, remarkable photoelectric photothermal conversion properties, outstanding biocompatibility. This review summarizes advancements photo‐responsive CDs for photodynamic the emerging photocatalytic tumors. Finally, article discusses main challenges development oncology therapeutics strategies overcome these challenges.

Language: Английский

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Mechanisms and applications of radiation-induced oxidative stress in regulating cancer immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 4, 2023

Radiotherapy (RT) is an effective treatment option for cancer patients, which induces the production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to death tumor cells. OS not only apoptosis, autophagy ferroptosis, but also affects immune response. The combination RT immunotherapy has revolutionized management various cancers. In this process, caused by ROS plays a critical role. Specifically, RT-induced can promote release tumor-associated antigens (TAAs), regulate infiltration differentiation cells, manipulate expression checkpoints, change microenvironment (TME). review, we briefly summarize several ways in IR cell discuss interrelationship between antitumor immunity, with focus on interaction ferroptosis immunogenic death. We potential mechanisms regulates checkpoint expression, cells activity, differentiation. addition, conclude therapeutic opportunity improving radiotherapy regulating OS, may be beneficial clinical treatment.

Language: Английский

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The role of tumor-associated macrophages in tumor immune evasion

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(5)

Published: May 7, 2024

Abstract Background Tumor growth is closely linked to the activities of various cells in tumor microenvironment (TME), particularly immune cells. During progression, circulating monocytes and macrophages are recruited, altering TME accelerating growth. These adjust their functions response signals from stromal Tumor-associated (TAMs), similar M2 macrophages, key regulators TME. Methods We review origins, characteristics, TAMs within This analysis includes mechanisms through which facilitate evasion promote metastasis. Additionally, we explore potential therapeutic strategies that target TAMs. Results instrumental mediating malignant behaviors. They release cytokines inhibit effector attract additional immunosuppressive primarily T cells, inducing exhaustion directly, influencing activity indirectly cellular interactions, or suppressing checkpoints. directly involved proliferation, angiogenesis, invasion, Summary Developing innovative tumor-targeted therapies immunotherapeutic currently a promising focus oncology. Given pivotal role evasion, several approaches have been devised them. include leveraging epigenetics, metabolic reprogramming, engineering repolarize TAMs, inhibiting recruitment activity, using as drug delivery vehicles. Although some these remain distant clinical application, believe future targeting will offer significant benefits cancer patients.

Language: Английский

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Oxidative Stress–Induced Liver Damage and Remodeling of the Liver Vasculature

American Journal Of Pathology, Journal Year: 2023, Volume and Issue: 193(10), P. 1400 - 1414

Published: June 23, 2023

As an organ critically important for targeting and clearing viruses, bacteria, other foreign material, the liver operates via immune-tolerant, anti-inflammatory mechanisms indispensable to immune response. Stress stress-induced factors disrupt homeostatic balance in liver, inflicting tissue damage, injury, remodeling. These include oxidative stress (OS) induced by viral infections, environmental toxins, drugs, alcohol, diet. A recurrent theme seen among stressors common multiple diseases is induction of mitochondrial dysfunction, increased reactive oxygen species expression, depletion ATP. Inflammatory signaling additionally exacerbates condition, generating a proinflammatory, immunosuppressive microenvironment activation apoptotic necrotic that integrity morphology. pathways initiate significantly contribute development steatosis, inflammation, fibrosis, cirrhosis, cancers. In addition, hypoxia OS directly enhance angiogenesis lymphangiogenesis chronic diseases. Late-stage consequences these conditions often narrow outcomes transplantation or result death. This review provides detailed perspective on various specific focus role different with special emphasis molecular mechanisms. It also highlights how resultant changes vasculature correlate pathogenesis. Stress-induced health issues are one major challenges modern society. Stress, which defined "conditions where demand exceeds natural regulatory capacity organism, particular situations unpredictability uncontrollability,"1Koolhaas J.M. Bartolomucci A. Buwalda B. de Boer S.F. Flugge G. Korte S.M. Meerlo P. Murison R. Olivier Palanza Richter-Levin Sgoifo Steimer T. Stiedl O. van Dijk Wohr M. Fuchs E. revisited: critical evaluation concept.Neurosci Biobehav Rev. 2011; 35: 1291-1301Crossref PubMed Scopus (982) Google Scholar can alter normal homeostasis human physiological psychological status.2Vere C.C. Streba C.T. L.M. Ionescu A.G. Sima F. Psychosocial disease status.World J Gastroenterol. 2009; 15: 2980-2986Crossref (65) Scholar,3Joung J.Y. Cho J.H. Kim Y.H. Choi S.H. Son C.G. literature injury.Brain Behav. 2019; 9e01235Crossref (43) Both experimental clinical studies show impacts hepatic physiology contributes Furthermore, it worsen patients cardiovascular diseases, cancer, HIV/AIDS.2Vere Scholar, 3Joung 4Cohen S. Janicki-Deverts D. Miller G.E. Psychological disease.JAMA. 2007; 298: 1685-1687Crossref (1952) Liver, largest solid body, center metabolism detoxification, site complex immunologic activity controlled diverse cells populations, as well nonhematopoietic cells.5Robinson M.W. Harmon C. O'Farrelly Liver immunology its inflammation homeostasis.Cell Mol Immunol. 2016; 13: 267-276Crossref (598) receives digested products, microbial agents, antigens from body through portal vein, elicit cell cause persistent regulated inflammation.6Racanelli V. Rehermann The immunological organ.Hepatology. 2006; 43: S54-S62Crossref (967) Prolonged exposure high-fat diet, hormones causes leading diseases.7Ozkan Stolley Cressman E.N.K. McMillin DeMorrow Yankeelov T.E. Rylander M.N. influence vasculature: liver-on-a-chip review.Micromachines (Basel). 2020; 11: 487Crossref Episodes such physiological, psychological, have negative impact long-term pre-existing conditions, hepatitis B virus (HBV),8Kunkel E.J. J.S. Hann H.W. Oyesanmi Menefee L.A. Field H.L. Lartey P.L. Myers R.E. Depression Korean immigrants related diseases.Psychosomatics. 2000; 41: 472-480Crossref (57) C (HCV),9Nagano J. Nagase Sudo N. Kubo stress, personality, severity C.Psychosomatics. 2004; 45: 100-106Crossref (38) alcoholic hepatitis,10Fukudo Suzuki Tanaka Y. Iwahashi Nomura Impact injury; histopathological study.J Psychosom Res. 1989; 33: 515-521Crossref nonalcoholic steatohepatitis,11Elwing J.E. Lustman P.J. Wang Clouse Depression, anxiety, steatohepatitis.Psychosom Med. 68: 563-569Crossref (100) (OS), endoplasmic reticulum (ER) hepatocellular carcinoma (HCC).12Luna-Marco Ubink Kopsida Heindryckx Endoplasmic carcinoma.Am Pathol. 2023; 193: 1377-1388Abstract Full Text PDF Scholar,13Brahma M.K. Gilglioni E.H. Zhou L. Trepo Chen Gurzov E.N. Oxidative obesity-associated carcinoma: sources, therapeutic challenges.Oncogene. 2021; 40: 5155-5167Crossref (16) stress-mediated damages, both hepatocytes nonparenchymal cells, present vasculature, impacted.7Ozkan current principal contributing damage progression disease. highly vascularized dense network blood vessels, bile ducts, lymphatic vessels. plays transforming toxic substances into form be eliminated. Compared organs has high receive cardiac output, up 25% output at rest.14Abdel-Misih S.R. Bloomston anatomy.Surg Clin North Am. 2010; 90: 643-653Abstract (179) first nutrient-rich intestines participates response.15Gibert-Ramos Sanfeliu-Redondo Aristu-Zabalza Martinez-Alcocer Gracia-Sancho Guixe-Muntet Fernandez-Iglesias sinusoid disease: optimal milieu cancer.Cancers 5719Crossref (4) unique because superimposition two inlet networks (ie, artery vein), running parallel; outlet composed central veins, veins.16Lorente Hautefeuille Sanchez-Cedillo functionalized vascular structure.Sci Rep. 1016194Crossref (28) vein play maintaining supply liver. divided hexagonal lobules, consist triads, resident cells. triad artery, ducts7Ozkan Scholar,17Fleischer J.R. Jodszuweit C.A. Ghadimi De Oliveira Conradi L.C. Vascular heterogeneity microenvironment.Front Physiol. 11591901Crossref (Figure 1). collects digestive tract, pancreas, spleen, approximately 75% liver's supply, whereas remaining supplied artery. venous mixes oxygenated flows sinusoid, microvascular bed sinusoids send vein.7Ozkan sinusoidal endothelial (LSECs) morphologically functionally they clustered fenestrations sieve plates,16Lorente discontinuous arrangement, lack typical basement membrane, attenuated extracellular matrix fibronectin component.18Xu Broome U. Uzunel Nava Ge X. Kumagai-Braesch Hultenby K. Christensson Ericzon B.G. Holgersson Sumitran-Holgersson Capillarization cell-reactive autoantibodies cirrhosis hepatitis.Am 2003; 163: 1275-1289Abstract adult length 250 μm, their diameter varies between 7 15 μm.19Vollmar Menger M.D. microcirculation: mechanistic contributions targets injury repair.Physiol 89: 1269-1339Crossref (368) Under arrangement LSECs facilitates exchange large molecules pathogens blood.18Xu Bile ducts carry gallbladder direction opposite sinusoids.20Du Khandekar Llewellyn Polacheck W. C.S. Wells R.G. duct-on-a-chip organ-level functions.Hepatology. 71: 1350-1363Crossref (41) Along system maintenance fluid homeostasis, response.21Burchill M.A. Goldberg A.R. Tamburini B.A.J. Emerging roles lymphatics disease.Front 10: 1579Crossref (11) Scholar,22Roy Banerjee Ekser Bayless Zawieja Alpini Glaser S.S. Chakraborty Targeting lymph node metastasis cancer.Am 191: 2052-2063Abstract (0) Recent murine models organized segmentally, intrahepatic vessels populated around triad.23Frenkel N.C. Poghosyan Verheem Padera T.P. Rinkes I. Kranenburg Hagendoorn drainage patterns follow segmental anatomy model.Sci 1021808Crossref Lymphatic capillaries, thin-walled single layered (LECs), collect lymph, rich cellular proteins, lipoproteins, lymphocytes, drain collecting Collecting unlike covered muscle pump nodes.21Burchill Scholar,24Tanaka Iwakiri system: structure, function, markers, lymphangiogenesis.Cell Gastroenterol Hepatol. 2: 733-749Abstract About 70% 80% parenchymal hepatocytes. Hepatocytes crucial metabolism, innate regulation, protein synthesis, secretion circulation.25Schulze R.J. Schott M.B. Casey Tuma McNiven biology hepatocyte: membrane trafficking machine.J Cell Biol. 218: 2096-2112Crossref (80) Scholar,26Zhou Z. Xu M.J. Gao Hepatocytes: key type immunity.Cell 301-315Crossref (247) main proteins secreted α-fetoprotein, serum albumin, transferrin, plasminogen, fibrinogen, α-1-antitrypsin, C-reactive protein, clotting (except factor VIII).25Schulze initiation acid (BA) then transported canaliculi. BAs take part emulsification, digestion dietary fats, removal metabolic wastes.25Schulze series ductules eventually transferred stored there until being hormonally stimulated released intestines. However, retained impaired toxicity.27Fang Han S.I. Mitchell Gupta Studer Grant Hylemon P.B. Dent acids induce ROS, promote receptor tyrosine kinases rat hepatocytes.Hepatology. 961-971Crossref (106) pathologic enhanced level BAs, deoxycholic acids, taurodeoxycholic (ROS) production, which, turn, activates downstream signal-regulated kinase 1/2 AKT pathways.27Fang ROS-mediated damage. High ROS stimulates hypertonicity, release cytochrome c hepatocyte apoptosis.28Wei Ma Zhao Mechanism hydrophobic acid-induced drug discovery.Front Pharmacol. 1084Crossref (26) three-dimensional duct, biliary tree, lined heterogeneous, dynamic population epithelial cholangiocytes, represent only 3% 5% total population.29Banales Huebert R.C. Karlsen Strazzabosco LaRusso N.F. Gores G.J. Cholangiocyte pathobiology.Nat Rev 16: 269-281Crossref (237) cholangiocytes responsible 30% flow humans, produced hepatocytes.29Banales Cholangiocytes activated several stimuli, xenobiotic cholestasis, ischemia, OS. Activated altered proliferation secrete variety profibrotic proinflammatory factors.29Banales Scholar,30Ostrycharz Wasik Kempinska-Podhorodecka Banales Milkiewicz Melatonin protects proapoptotic stimuli miR-132 miR-34.Int Sci. 21: 9667Crossref (13) Hepatic stellate (HSCs), 10% liver-specific fibroblasts reside space Disse, healthy HSCs primary storage sites vitamin A.15Gibert-Ramos case get activated, differentiate myofibroblasts, produce components, fibrosis Interestingly, plethora cytokines chemokines, monocyte chemoattractant 1, IL-6, growth factor-β, enable leukocyte recruitment Recruited leukocytes response further HSCs.31Winau Quack Darmoise Kaufmann Starring immunology.Curr Opin 2008; 20: 68-74Crossref (70) OS, activate quiescent long run, HCC.32Ramos-Tovar Muriel Molecular link liver.Antioxidants 9: 1279Crossref (99) Kupffer (KCs) macrophages adherent wall KCs serves line defense against bacterial infection host response.33Fox E.S. Thomas Broitman S.A. Comparative endotoxin uptake isolated peritoneal cells.Infect Immun. 1987; 55: 2962-2966Crossref 34Bilzer Roggel Gerbes A.L. Role disease.Liver Int. 26: 1175-1186Crossref (651) 35Bleriot Dupuis Jouvion Eberl Disson Lecuit Liver-resident macrophage necroptosis orchestrates 1 microbicidal type-2-mediated repair during infection.Immunity. 2015; 42: 145-158Abstract (309) differentiated M1-like (classic) M2-like (alternative) macrophages. sources cytokines, damage.36Liu Tao Q. Sun Wu J.Z. Yang Jian Peng Hu Liu associated apoptosis, fibrotic effects rats.Lab Invest. 1805-1816Abstract (109) Scholar,37Zhang Zhu X.D. H.C. Xiong Y.Q. Zhuang P.Y. H.X. Kong L.Q. W.Z. Tang Z.Y. Depletion tumor-associated enhances effect sorafenib metastatic cancer antimetastatic antiangiogenic effects.Clin Cancer 3420-3430Crossref (313) oxidized low-density lipoprotein, lipopolysaccharide, infiltrating NADPH oxidase 2 (Nox2), stimulate [eg, tumor necrosis (TNF)-α, IL-1β].38Kim S.Y. Jeong S.J. Seo M.H. W.M. Yoo Lee Shim Y.R. Yi H.S. Y.S. Eun B.S. Chun Kang S.C. Kunos H.M. W.I. Pro-inflammatory generate endocytosis monomeric TLR4-MD2 complex.Nat Commun. 2017; 8: 2247Crossref (147) specialized interface lumen contrast display clusters plates.39Wisse Zanger R.B. Charels Van Der Smissen McCuskey R.S. sieve: considerations concerning structure function fenestrae, Disse.Hepatology. 1985; 5: 683-692Crossref (581) Because permeable membrane.40Braet Wisse Structural functional aspects fenestrae: review.Comp 2002; 1: 1Crossref (572) selectively control diffusion substrate Disse.41Poisson Lemoinne Boulanger Durand Moreau Valla Rautou P.E. cells: diseases.J 66: 212-227Abstract (549) Scholar,42Geraud Evdokimov Straub B.K. Peitsch W.K. Demory Dorflinger Schledzewski Schmieder Schemmer Augustin H.G. Schirmacher Goerdt Unique type-specific junctional complexes endothelium sinusoids.PLoS One. 2012; 7e34206Crossref (48) phenotypes maintained factor-A (VEGF-A) stimulation nitric oxide–dependent oxide–independent signaling.43Xie Atkinson R.D. Kanel G.C. Gaarde W.A. Deleve L.D. differentiation regression rats.Gastroenterology. 142: 918-927.e6Abstract (259) keep quiescent. source fibrillar collagens components scar.44Wells Cellular fibrosis.Clin Dis. 12 (viii): 759-768Abstract (146) Scholar,45Kisseleva Brenner regression.Nat 18: 151-166Crossref (594) diseased damaged factor-β hepatocytes, damage.7Ozkan Scholar,34Bilzer lymph-producing system.46Tanaka Lymphatics liver.Curr 2018; 53: 137-142Crossref plasma component filtered fenestrae Disse. mall, enters interstitial triad, finally capillaries.24Tanaka primarily located nearby draining nodes outside liver.47Ohtani Ohtani Lymph circulation liver.Anat Rec (Hoboken). 291: 643-652Crossref (138) Inside LECs, identified markers vessel hyaluronan (Lyve-1), prospero homeobox (Prox1), podoplanin, absence α-smooth actin–positive (smooth cells/pericytes). express Lyve-1, Prox1.48Truman Bentley K.L. Smith E.C. Massaro Gonzalez D.G. Haberman A.M. Hill Jones Min Krause D.S. Ruddle N.H. ProxTom reporter mice reveal Prox1 expression adrenal medulla, megakaryocytes, platelets.Am 180: 1715-1725Abstract Thus, co-existence above three identifies LECs. livers, LECs required maintain fat cholesterol scavenger class I.49Lim H.Y. Thiam C.H. Yeo K.P. Bisoendial Hii McGrath K.C. Tan K.W. Heather Alexander Angeli essential peripheral tissues SR-BI-mediated transport HDL.Cell Metab. 2013; 17: 671-684Abstract (217) Scholar,50Martel Randolph Atherosclerosis transit HDL vasculature.Curr Atheroscler 354Crossref (22) Several report that, under production increases expansion lymphangiogenesis.24Tanaka Scholar,51Banerjee Kumaravel Roy Gaddam Odeh K.J. Conjugated modulation species-p90RSK-vascular 3 pathway.Cells. 12: 526Crossref 52Singla Aithabathula R.V. Kiran Kapil Kumar Singh U.P. Reactive regulating function.Cells. 2022; 1750Crossref Schola

Language: Английский

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