Toxicology Research,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Jan. 1, 2024
Abstract
The
2022
US
Cancer
Statistics
show
that
breast
cancer
is
one
of
the
most
common
cancers
in
women.
Epidemiology
has
shown
adding
flavonoids
to
diet
inhibits
arise
particular
women,
such
as
cervical
cancer,
ovarian
and
cancer.
Although
there
have
been
research
reports
on
apigenin
(API)
its
anti-tumor
effect
potential
mechanism
not
yet
clarified.
Therefore,
this
study,
we
used
4T1
cells
a
xenograft
tumor
mouse
model
investigate
antitumor
API
underlying
mechanism.
In
vitro,
MTT,
transwell,
staining,
western
blotting
inhibitory
molecular
vivo
by
establishing
model,
using
immunohistochemistry,
flow
cytometry
study
solid
tumors
immune
microenvironment.
results
showed
can
induce
cell
apoptosis
through
PI3K/AKT/Nrf2
pathway
improve
microenvironment
mice
with
tumors,
thereby
inhibiting
growth
Thus,
may
be
promising
agent
for
treatment.
Redox Biology,
Journal Year:
2022,
Volume and Issue:
52, P. 102317 - 102317
Published: April 21, 2022
Chemotherapy
is
still
one
of
the
principal
treatments
for
gastric
cancer,
but
clinical
application
5-FU
limited
by
drug
resistance.
Here,
we
demonstrate
that
ferroptosis
triggered
STAT3
inhibition
may
provide
a
novel
opportunity
to
explore
new
effective
therapeutic
strategy
cancer
and
chemotherapy
We
find
negative
regulation
(FNR)
signatures
are
closely
correlated
with
progression
chemoresistance
cancer.
FNR
associated
genes
(GPX4,
SLC7A11,
FTH1)
upregulated
in
resistant
cells
xenografts.
Further
evidence
demonstrates
binds
consensus
DNA
response
elements
promoters
regulates
their
expression,
thereby
establishing
STAT3-ferroptosis
regulatory
axis
Genetic
activity
triggers
through
lipid
peroxidation
Fe2+
accumulation
cells.
further
develop
potent
selective
inhibitor,
W1131,
which
significant
anti-tumor
effects
cell
xenograft
model,
organoids
patient-derived
xenografts
(PDX)
model
partly
inducing
ferroptosis,
thus
providing
candidate
compound
advanced
Moreover,
targeting
circuit
promotes
restores
sensitivity
chemotherapy.
Our
finding
reveals
acts
as
key
regulator
multi-pronged
mechanism
provides
Molecules,
Journal Year:
2022,
Volume and Issue:
27(18), P. 6051 - 6051
Published: Sept. 16, 2022
Cancer
is
the
leading
cause
of
death
worldwide.
In
spite
advances
in
treatment
cancer,
currently
used
modules
including
chemotherapy,
hormone
therapy,
radiation
therapy
and
targeted
causes
adverse
effects
kills
normal
cells.
Therefore,
goal
more
effective
less
side
effects-based
cancer
approaches
still
at
primary
position
present
research.
Medicinal
plants
or
their
bioactive
ingredients
act
as
dynamic
sources
drugs
due
to
having
also
shows
role
reduction
resistance
against
therapy.
Apigenin
an
edible
plant-derived
flavonoid
that
has
received
significant
scientific
consideration
for
its
health-promoting
potential
through
modulation
inflammation,
oxidative
stress
various
other
biological
activities.
Moreover,
anti-cancer
apigenin
confirmed
ability
modulate
cell
signalling
pathways,
tumor
suppressor
genes,
angiogenesis,
apoptosis,
cycle,
PI3K/AKT,
NF-κB,
MAPK/ERK
STAT3
pathways.
The
current
review
mainly
emphases
different
types
signaling
Further
studies
based
on
clinical
trials
are
needed
explore
management
explain
possible
mechanisms
action
this
vista.
Food Reviews International,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 50
Published: Jan. 4, 2025
Cancer
is
the
world's
second
most
common
cause
of
death,
with
colon
cancer
(CC)
ranking
third
in
prevalence
and
cancer-related
fatalities.
CC
originates
or
rectum
influenced
by
genetic
mutations,
lifestyle,
diet.
Although
chemotherapy,
especially
5-fluorouracil
(5-FU),
fundamental
to
treatment
has
improved
patient
survival,
its
benefits
are
often
limited
significant
side
effects
emerging
drug
resistance.
Recently,
plant-based
foods
have
drawn
interest
research
for
their
natural
bioactive
compounds
relatively
low
toxicity.
Certain
plant
not
only
exhibit
anti-cancer
activity
but
may
also
boost
effectiveness
5-FU
while
reducing
adverse
effects.
Despite
evidence
suggesting
a
synergistic
effect
between
5-FU,
this
area
remains
fragmented.
This
review
consolidates
current
on
including
fruits,
vegetables,
legumes,
tea
bioactives
treatment.
Besides,
it
explores
mechanisms
through
which
these
enhance
efficacy
reduce
effects,
evaluates
clinical
application
prospects,
identifies
challenges
future
directions.
comprehensive
analysis
aims
provide
scientific
foundation
integrated
CC,
highlighting
potential
enhancing
chemotherapy
associated
toxicities.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2023,
Volume and Issue:
1878(6), P. 189024 - 189024
Published: Nov. 1, 2023
For
decades,
common
chemotherapeutic
drugs
have
been
established
to
trigger
apoptosis,
the
preferred
immunologically
"silent"
form
of
cell
death.
The
primary
objective
this
review
was
show
that
various
FDA-approved
drugs,
including
cisplatin,
cyclosporine,
doxorubicin,
etoposide,
5-fluorouracil,
gemcitabine,
paclitaxel,
or
vinblastine
can
necroptosis
and
pyroptosis.
We
aimed
provide
advantages
disadvantages
induction
given
type
death
by
chemotherapeutical
agents.
Moreover,
we
give
a
short
overview
molecular
mechanism
each
indicate
existing
crosstalks
between
types.
Finally,
comparison
types
facilitate
exploration
induced
other
Understanding
pathway
drug
lessen
side
effects
assist
discovery
new
combinations
with
synergistic
low
systemic
toxicity.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(3), P. 1193 - 1193
Published: Jan. 25, 2023
In
most
cases,
cancer
develops
due
to
abnormal
cell
growth
and
subsequent
tumour
formation.
Due
significant
constraints
with
current
treatments,
natural
compounds
are
being
explored
as
potential
alternatives.
There
now
around
30
under
clinical
trials
for
the
treatment
of
cancer.
Tulsi,
or
Holy
Basil,
genus
Ocimum,
is
one
widely
available
cost-effective
medicinal
plants.
India,
tulsi
plant
has
deep
religious
significance.
Tulsi
essential
oil
contains
a
valuable
source
bioactive
compounds,
such
camphor,
eucalyptol,
eugenol,
alpha-bisabolene,
beta-bisabolene,
beta-caryophyllene.
These
proposed
be
responsible
antimicrobial
properties
leaf
extracts.
The
anticancer
effects
(Ocimum
sanctum
L.)
have
earned
it
title
“queen
herbs”
“Elixir
Life”
in
Ayurvedic
treatment.
leaves,
which
high
concentrations
been
shown
properties.
various
cancers,
eugenol
exerts
its
antitumour
through
number
different
mechanisms.
light
this,
review
focuses
on
benefits
primary
phytoconstituent,
apotential
therapeutic
agent
against
wide
range
types.
recent
years,
gained
popularity
ongoing
trials,
evaluated
their
effects.
This
article
discusses
anticancer,
chemopreventive,
antioxidant
tulsi.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(9), P. 3746 - 3746
Published: April 26, 2023
This
review
article
describes
studies
published
over
the
past
five
years
on
combination
of
polyphenols,
which
are
most
studied
in
field
anticancer
effects
(curcumin,
quercetin,
resveratrol,
epigallocatechin
gallate,
and
apigenin)
chemotherapeutics
such
as
cisplatin,
5-fluorouracil,
oxaliplatin,
paclitaxel,
etc.
According
to
WHO
data,
research
has
been
limited
cancers
with
highest
morbidity
rate
(lung,
colorectal,
liver,
gastric,
breast
cancer).
A
systematic
articles
(from
January
2018
2023)
was
carried
out
help
all
Web
Science
databases
available
base
clinical
studies.
Based
preclinical
presented
this
review,
polyphenols
can
enhance
drug
efficacy
reduce
chemoresistance
through
different
molecular
mechanisms.
Considering
large
number
studies,
curcumin
could
be
a
molecule
future
chemotherapy
cocktails.
One
main
problems
is
related
bioavailability
polyphenols.
The
design
new
co-delivery
system
for
drugs
essential
research.
Some
work
synergy
chemotherapeutic
drugs,
but
some
act
antagonistically,
so
caution
always
required.
