Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer

Redox Biology, Journal Year: 2022, Volume and Issue: 52, P. 102317 - 102317

Published: April 21, 2022

Chemotherapy is still one of the principal treatments for gastric cancer, but clinical application 5-FU limited by drug resistance. Here, we demonstrate that ferroptosis triggered STAT3 inhibition may provide a novel opportunity to explore new effective therapeutic strategy cancer and chemotherapy We find negative regulation (FNR) signatures are closely correlated with progression chemoresistance cancer. FNR associated genes (GPX4, SLC7A11, FTH1) upregulated in resistant cells xenografts. Further evidence demonstrates binds consensus DNA response elements promoters regulates their expression, thereby establishing STAT3-ferroptosis regulatory axis Genetic activity triggers through lipid peroxidation Fe2+ accumulation cells. further develop potent selective inhibitor, W1131, which significant anti-tumor effects cell xenograft model, organoids patient-derived xenografts (PDX) model partly inducing ferroptosis, thus providing candidate compound advanced Moreover, targeting circuit promotes restores sensitivity chemotherapy. Our finding reveals acts as key regulator multi-pronged mechanism provides

Language: Английский

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Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 188, P. 114445 - 114445

Published: July 9, 2022

Language: Английский

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The Potential Role of Apigenin in Cancer Prevention and Treatment

Molecules, Journal Year: 2022, Volume and Issue: 27(18), P. 6051 - 6051

Published: Sept. 16, 2022

Cancer is the leading cause of death worldwide. In spite advances in treatment cancer, currently used modules including chemotherapy, hormone therapy, radiation therapy and targeted causes adverse effects kills normal cells. Therefore, goal more effective less side effects-based cancer approaches still at primary position present research. Medicinal plants or their bioactive ingredients act as dynamic sources drugs due to having also shows role reduction resistance against therapy. Apigenin an edible plant-derived flavonoid that has received significant scientific consideration for its health-promoting potential through modulation inflammation, oxidative stress various other biological activities. Moreover, anti-cancer apigenin confirmed ability modulate cell signalling pathways, tumor suppressor genes, angiogenesis, apoptosis, cycle, PI3K/AKT, NF-κB, MAPK/ERK STAT3 pathways. The current review mainly emphases different types signaling Further studies based on clinical trials are needed explore management explain possible mechanisms action this vista.

Language: Английский

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Pre-clinical and clinical importance of miR-21 in human cancers: Tumorigenesis, therapy response, delivery approaches and targeting agents

Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106568 - 106568

Published: Nov. 21, 2022

Language: Английский

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Plant Foods and Their Bioactives as Dietary Enhancers for Colon Cancer Treatment with 5-Fluorouracil

Food Reviews International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 50

Published: Jan. 4, 2025

Cancer is the world's second most common cause of death, with colon cancer (CC) ranking third in prevalence and cancer-related fatalities. CC originates or rectum influenced by genetic mutations, lifestyle, diet. Although chemotherapy, especially 5-fluorouracil (5-FU), fundamental to treatment has improved patient survival, its benefits are often limited significant side effects emerging drug resistance. Recently, plant-based foods have drawn interest research for their natural bioactive compounds relatively low toxicity. Certain plant not only exhibit anti-cancer activity but may also boost effectiveness 5-FU while reducing adverse effects. Despite evidence suggesting a synergistic effect between 5-FU, this area remains fragmented. This review consolidates current on including fruits, vegetables, legumes, tea bioactives treatment. Besides, it explores mechanisms through which these enhance efficacy reduce effects, evaluates clinical application prospects, identifies challenges future directions. comprehensive analysis aims provide scientific foundation integrated CC, highlighting potential enhancing chemotherapy associated toxicities.

Language: Английский

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Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models

Critical Reviews in Oncology/Hematology, Journal Year: 2022, Volume and Issue: 176, P. 103751 - 103751

Published: June 22, 2022

Language: Английский

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Apoptosis, necroptosis, and pyroptosis as alternative cell death pathways induced by chemotherapeutic agents?

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(6), P. 189024 - 189024

Published: Nov. 1, 2023

For decades, common chemotherapeutic drugs have been established to trigger apoptosis, the preferred immunologically "silent" form of cell death. The primary objective this review was show that various FDA-approved drugs, including cisplatin, cyclosporine, doxorubicin, etoposide, 5-fluorouracil, gemcitabine, paclitaxel, or vinblastine can necroptosis and pyroptosis. We aimed provide advantages disadvantages induction given type death by chemotherapeutical agents. Moreover, we give a short overview molecular mechanism each indicate existing crosstalks between types. Finally, comparison types facilitate exploration induced other Understanding pathway drug lessen side effects assist discovery new combinations with synergistic low systemic toxicity.

Language: Английский

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Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 241, P. 124508 - 124508

Published: April 20, 2023

Language: Английский

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Combination Chemotherapy with Selected Polyphenols in Preclinical and Clinical Studies—An Update Overview

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3746 - 3746

Published: April 26, 2023

This review article describes studies published over the past five years on combination of polyphenols, which are most studied in field anticancer effects (curcumin, quercetin, resveratrol, epigallocatechin gallate, and apigenin) chemotherapeutics such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, etc. According to WHO data, research has been limited cancers with highest morbidity rate (lung, colorectal, liver, gastric, breast cancer). A systematic articles (from January 2018 2023) was carried out help all Web Science databases available base clinical studies. Based preclinical presented this review, polyphenols can enhance drug efficacy reduce chemoresistance through different molecular mechanisms. Considering large number studies, curcumin could be a molecule future chemotherapy cocktails. One main problems is related bioavailability polyphenols. The design new co-delivery system for drugs essential research. Some work synergy chemotherapeutic drugs, but some act antagonistically, so caution always required.

Language: Английский

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An Update on the Therapeutic Anticancer Potential of Ocimum sanctum L.: “Elixir of Life”

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1193 - 1193

Published: Jan. 25, 2023

In most cases, cancer develops due to abnormal cell growth and subsequent tumour formation. Due significant constraints with current treatments, natural compounds are being explored as potential alternatives. There now around 30 under clinical trials for the treatment of cancer. Tulsi, or Holy Basil, genus Ocimum, is one widely available cost-effective medicinal plants. India, tulsi plant has deep religious significance. Tulsi essential oil contains a valuable source bioactive compounds, such camphor, eucalyptol, eugenol, alpha-bisabolene, beta-bisabolene, beta-caryophyllene. These proposed be responsible antimicrobial properties leaf extracts. The anticancer effects (Ocimum sanctum L.) have earned it title “queen herbs” “Elixir Life” in Ayurvedic treatment. leaves, which high concentrations been shown properties. various cancers, eugenol exerts its antitumour through number different mechanisms. light this, review focuses on benefits primary phytoconstituent, apotential therapeutic agent against wide range types. recent years, gained popularity ongoing trials, evaluated their effects. This article discusses anticancer, chemopreventive, antioxidant tulsi.

Language: Английский

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