Improvement of Cardiovascular Risk Factors by Genistein Supplementation: A Systematic Review and Meta‐Analysis in Diverse Population‐Based RCTs DOI Creative Commons

Hanxiao Feng,

Kuan Jiang, Yifeng Zhang

et al.

Journal of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Genistein[5,7‐dihydroxy‐3‐(4‐hydroxyphenyl)chromen‐4‐one] is a phytoestrogens known to positively impact various cardiovascular disease (CVD) risk factors. However, not all studies have yielded consistent results, and existing meta‐analyses comprehensively addressed CVD We conducted systematic search of the PubMed, ISI Web Science, Embase, Cochrane Library databases up June 2024, following PRISMA 2020 guidelines. included adult randomized controlled trials (RCTs) that examined pure genistein supplementation without other combined interventions reported on at least one factor. Data extraction quality assessment were performed independently by two authors using standardized form Collaboration Scale. A total 21 RCTs included, with 941 participants in group 918 control group. Statistical analyses R software meta package. The meta‐analysis revealed that, compared placebo group, significantly improved levels TC ([MD 95% CI: −9.38 [−14.64, −4.12]; p < 0.001]), LDL‐C −11.14 [−19.42, −2.86]; Lp(a) −0.69 [−0.98, −0.41]; 0.01), SBP −8.32 [−12.44, −4.20]; DBP −3.57 [−5.25, −1.89]; P = 0.04]), fasting blood glucose −3.98 [−6.79, −1.17]; insulin −1.79 [−2.05, −1.54]; HOMA‐IR −0.56 [−0.64, −0.49]; homocysteine −0.74 [−1.05, −0.42]; 0.01). there no significant improvements TG, HDL‐C, CRP levels. observed align clinically meaningful thresholds for reduction. Substantial heterogeneity most outcomes was explored via subgroup analysis. Subgroup based treatment duration, geographic region, or participant health status, assessed I 2 statistic. analysis did reveal any differences, indicating influenced factors such as status. Overall, this provides evidence intake reduces several important factors, including TC, LDL‐C, Lp(a), SBP, DBP, glucose, insulin, HOMA‐IR,

Language: Английский

Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis DOI Creative Commons

Sufang Zhong,

Wenjin Chen,

Bocheng Wang

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 63, P. 102760 - 102760

Published: May 23, 2023

Cancer cells and ischemic diseases exhibit unique metabolic responses adaptations to energy stress. Forkhead box O 3a (FoxO3a) is a transcription factor that plays an important role in cell metabolism, mitochondrial dysfunction oxidative stress response. Although the AMP-activated protein kinase (AMPK)/FoxO3a signaling pathway pivotal maintaining homeostasis under conditions of stress, AMPK/FoxO3a mitochondria-associated ferroptosis has not yet been fully elucidated. We show glucose starvation induced activation inhibited by erastin. Inhibition AMPK or loss FoxO3a cancer condition can sensitize these ferroptosis. Glucose deprivation mitochondria-related gene expression, reduced DNA(mtDNA) copy number, decreased expression proteins lowered levels respiratory complexes inducing FoxO3a. Loss promoted membrane potential hyperpolarization, oxygen consumption, lipid peroxide accumulation abolished protective effects on vitro. In addition, we identified FDA-approved antipsychotic agent, potent agonist trifluoperazine, which largely ferroptosis-associated cerebral ischemia-reperfusion (CIR) injuries rats through AMPK/FoxO3a/HIF-1α mitochondria-dependent mechanisms. found binds promoters SLC7A11 reduces CIR-mediated glutamate excitotoxicity inhibiting SLC7A11. Collectively, results suggest modulation regulates activity alters The regulation may play crucial controls balance confers resistance CIR injuries.

Language: Английский

Citations

62
Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling DOI Creative Commons
Min Wang, Tian Tian, Zhou Hong

et al.

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: April 2, 2024

Abstract Background Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuroprotective activities. However, its effect on astrocyte senescence PD remains to be defined. Methods Long culture-induced replicative model 1-methyl-4-phenylpyridinium/α-synuclein aggregate-induced premature model, mouse of were investigate the metformin vivo vitro. Immunofluorescence staining flow cytometric analyses performed evaluate mitochondrial function. We stereotactically injected AAV carrying GFAP-promoter-cGAS-shRNA substantia nigra pars compacta regions specifically reduce astrocytic cGAS expression clarify potential molecular mechanism by which inhibited PD. Results showed that vitro mice. Mechanistically, normalized function DNA release through mitofusin 2 (Mfn2), leading inactivation cGAS-STING, delayed prevented neurodegeneration. Mfn2 overexpression reversed inhibitory role cGAS-STING activation senescence. More importantly, ameliorated dopamine neuron injury behavioral deficits mice reducing accumulation senescent via inhibition activation. Deletion abolished suppressive Conclusions This work reveals delays inhibiting Mfn2-cGAS suggest is promising therapeutic agent diseases.

Language: Английский

Citations

18
Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway DOI Creative Commons

Ziang Zheng,

Xinghan Zhao,

Bo Yuan

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Jan. 8, 2024

Abstract Background Soy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the therapeutic potential of SI in treatment osteosarcoma (OS) and investigate underlying mechanisms, particularly focusing mitophagy. Methods The proliferation, apoptosis, migration, invasion U2OS cells were analyzed. Mitophagy was assessed through multiple parameters: mitochondrial autophagosomes, membrane potential, autophagy-related proteins, reactive oxygen species (ROS), consumption rate (OCR). Protein levels related autophagy, AKT/mTOR pathway analyzed using western blot. efficacy further identified mouse tumor xenograft model. Cell apoptosis proliferation xenografts detected by TUNEL staining immunohistochemistry (IHC), respectively. Results dose-dependently suppressed viability, colony formation, cells, enhanced apoptosis. also induced mitophagy OS evidenced an increase autophagosomes ROS levels, decrease OCR, concomitant changes proteins. Mdivi-1, inhibitor mitophagy, reversed anti-tumor cells. In addition, blocked SC-79, AKT agonist, effect inducing Moreover, promoted cell vivo . Conclusions induces blocking pathway, contributing inhibition OS.

Language: Английский

Citations

10
Mitochondrial homeostasis: shaping health and disease DOI Creative Commons
Xiaoyu Li, Ou Jiang, Mo Chen

et al.

Current Medicine, Journal Year: 2024, Volume and Issue: 3(1)

Published: April 15, 2024

Abstract Mitochondria serve as the primary site for metabolizing three major nutrients, underscoring their pivotal role in cellular energy metabolism and regulation of signaling pathways. Mitochondrial homeostatic imbalance is a key pathological cause development many diseases. Hence, preserving mitochondrial homeostasis vital normal growth cells organisms. Living organisms have evolved intricate regulatory mechanisms to ensure homeostasis. This review focuses on recent advancements comprehending responsible maintaining addresses current challenges this field. We also provide an overview functions mitochondria both physiological conditions. Emphasizing potential therapeutic implications, we discuss strategies homeostasis, recognizing its significance mitigating various health Graphical

Language: Английский

Citations

9
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis DOI Creative Commons
Jiaqi Yao, Yuhong Jiang, Pengcheng Zhang

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107620 - 107620

Published: Jan. 21, 2025

Language: Английский

Citations

1
The Potential Mechanism of Soy Isoflavones in Treating Osteoporosis: Focusing on Bone Metabolism and Oxidative Stress DOI Open Access
Yuanyuan Zhou,

Zhan Su,

Gang Liu

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Osteoporosis is divided into primary and secondary types. Primary osteoporosis may result from estrogen deficiency in postmenopausal women, imbalanced bone remodeling the elderly, or adolescent-type development. Secondary can be caused by factors like long-term glucocorticoid treatment, chronic kidney disease (CKD), deprivation, oxidative stress, diabetes, obesity. This review focuses on therapeutic potential of soy isoflavones for osteoporosis. At cellular level, isoflavones, as natural plant extracts phytoestrogens, are crucial osteoblastogenesis differentiation, osteoclastogenesis, osteoclast mineralization, marrow mesenchymal stromal cell differentiation. They also maintain calcium homeostasis regulating extracellular vitamin D levels. In terms mitigate it endoplasmic reticulum mitochondria, thus senescence, autophagy, processes. Moreover, relieve symptoms related to CKD inhibit secretion, which directly indirectly benefits treatment Overall, have treat enhancing health, metabolism, alleviating stress. Future research should explore phytoestrogens treating exploration focus clarifying safety, identifying side effects, determining optimal dosage regimen, developing strategies any adverse reactions. addition, further large-scale, multicenter human clinical trials necessary accurately evaluate actual effect

Language: Английский

Citations

1
l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy DOI Creative Commons
Yang Shen, Haoming Wang,

Hongwei Xie

et al.

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 46, P. 53 - 64

Published: May 1, 2024

Osteoporosis is one of the most common bone diseases in middle-aged and elderly populations worldwide. The development new drugs to treat disease a key focus research. Current treatments for osteoporosis are mainly directed at promoting osteoblasts inhibiting osteoclasts. However, there currently no ideal approach treatment. l-arginine semi-essential amino acid involved number cellular processes, including nitric production, protein biosynthesis, immune responses. We previously reported that l-arginine-derived compounds can play regulatory role homeostasis. To investigate specific effect on Mildly aged ovariectomized mouse models were used study effects osteogenesis angiogenesis, assessed by micro-computed tomography immunostaining tissue. osteogenesis, adipogenesis was further studied vitro using obtained from cranial cap bone, endothelial cells, an adipogenic cell line. Specific methods assess these processes included lipid staining, migration, tube-forming, wound-healing assays. Protein mRNA expression determined select biomarkers. found attenuated loss promoted angiogenesis. increased activity vascular whereas it inhibited vitro. In addition, we altered PINK1/Parkin Bnip3 mitochondria osteoblast-lineage thereby mitophagy protecting cells ROS. Similarly, treatment effectively ameliorated model. promotes angio-osteogenesis, inhibits adipogenesis, mediated PINK1/Parkin- Bnip3-mediated mitophagy. L-arginine supplementation may be effective adjunct therapy osteoporosis.

Language: Английский

Citations

8
Curcumin delivery using tetrahedral framework nucleic acids enhances bone regeneration in osteoporotic rats DOI
Long Bai,

Maogeng Feng,

Qiumei Li

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 472, P. 144978 - 144978

Published: July 22, 2023

Language: Английский

Citations

16
Nanozymes With Osteochondral Regenerative Effects: An Overview of Mechanisms and Recent Applications DOI

Xueheng Sun,

Xu Xiang, Xiaokun Yue

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 26, 2023

Abstract With the discovery of intrinsic enzyme‐like activity metal oxides, nanozymes garner significant attention due to their superior characteristics, such as low cost, high stability, multi‐enzyme activity, and facile preparation. Notably, in field biomedicine, primarily focus on disease detection, antibacterial properties, antitumor effects, treatment inflammatory conditions. However, potential for application regenerative medicine, which addresses wound healing, nerve defect repair, bone regeneration, cardiovascular treatment, is garnering interest well. This review introduces an innovative strategy within realm medicine. The primary this approach lies facilitation osteochondral regeneration through modulation pathological microenvironment. catalytic mechanisms four types representative are first discussed. microenvironment inhibiting followed by summarizing therapy mechanism barriers introduced. Further, therapeutic diseases included. To improve efficiency facilitate clinical translation, future applications also discussed some challenges addressed.

Language: Английский

Citations

16
Bioactive composite hydrogel with effects of robust promoting osteogenesis and immunomodulation for osteoporotic bone regeneration DOI
Bin Sun, Hufei Wang, Bing Xiao

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146743 - 146743

Published: Oct. 17, 2023

Language: Английский

Citations

15