Key Mechanisms of Oxidative Stress-Induced Ferroptosis in Heart Failure with Preserved Ejection Fraction and Potential Therapeutic Approaches DOI Creative Commons

Junling Lin,

Bingtao Li,

Xueqi Guo

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(3)

Published: March 25, 2025

The prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing annually, particularly among patients metabolic disorders such as hypertension and diabetes. However, there currently no treatment capable altering the natural course HFpEF. Recently, interplay between oxidative stress ferroptosis in cardiovascular diseases has drawn extensive attention; however, minimal research been published on mechanisms This paper reviews relevant through which induced promotes during development review also explores more efficacious approaches for HFpEF by inhibiting ferroptosis, thereby offering a theoretical foundation verifying feasibility these methods further research. As tumor-targeted therapy progresses, survival period tumor prolonged, events have gradually emerged one most crucial causes death patients. Hence, vascular endothelial growth factor (VEGF) pathway become major target treatment, significantly enhancing patient survival. Nevertheless, secondary complications events, myocardial injury subsequent failure, severely impacted quality life. Therefore we explored potential mechanism novel targeted anti-cancer drugs induce via ferroptosis. Additionally, reviewed specific modes action preventing treating without influencing their therapeutic effect.

Language: Английский

Mesenchymal stem cell attenuates spinal cord injury by inhibiting mitochondrial quality control-associated neuronal ferroptosis DOI Creative Commons

Senyu Yao,

Mao Pang, Yanheng Wang

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 67, P. 102871 - 102871

Published: Sept. 7, 2023

Ferroptosis is a newly discovered form of iron-dependent oxidative cell death and drives the loss neurons in spinal cord injury (SCI). Mitochondrial damage critical contributor to neuronal death, while mitochondrial quality control (MQC) an essential process for maintaining homeostasis promote survival. However, role MQC ferroptosis has not been clearly elucidated. Here, we further demonstrate that primarily suffer from SCI at single sequencing level. Mechanistically, disordered aggravates through excessive fission mitophagy. Furthermore, mesenchymal stem cells (MSCs)-mediated transfer restores mitochondria pool inhibits fusion by intercellular tunneling nanotubes. Collectively, these results only suggest regulated MQC-dependent manner, but also fulfill molecular mechanism which MSCs attenuate subcellular organelle More importantly, it provides promising clinical translation strategy based on cell-mediated therapy mitochondria-related central nervous system disorders.

Language: Английский

Citations

51
Mitochondrial dysfunction: A fatal blow in depression DOI Open Access
Yu Song, Huấn Cao, Chengchao Zuo

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115652 - 115652

Published: Oct. 4, 2023

Mitochondria maintain the normal physiological function of nerve cells by producing sufficient cellular energy and performing crucial roles in maintaining metabolic balance through intracellular Ca2+ homeostasis, oxidative stress, axonal development. Depression is a prevalent psychiatric disorder with an unclear pathophysiology. Damage to hippocampal neurons key component plasticity regulation synapses plays critical role mechanism depression. There evidence suggesting that mitochondrial dysfunction associated synaptic impairment. The maintenance homeostasis includes quantitative quality control mitochondria. Mitochondrial biogenesis produces new healthy mitochondria, dynamics cooperates mitophagy remove damaged These processes population stability exert neuroprotective effects against early In contrast, observed various brain regions patients major depressive disorders. accumulation defective mitochondria accelerates dysfunction. addition, impaired aggravate alterations microenvironment, promoting neuroinflammation depletion, thereby exacerbating development This review summarizes influence underlying molecular pathways on pathogenesis Additionally, we discuss as potential therapeutic strategy for

Language: Английский

Citations

50
Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury DOI Creative Commons
Dan Wu,

Charles B. Spencer,

Lilibeth Ortoga

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 74, P. 103194 - 103194

Published: May 16, 2024

Elevated lactate levels are a significant biomarker of sepsis and positively associated with sepsis-related mortality. Sepsis-associated lung injury (ALI) is leading cause poor prognosis in clinical patients. However, the underlying mechanisms lactate's involvement sepsis-associated ALI remain unclear. In this study, we demonstrate that regulates N6-methyladenosine (m6A) modification by facilitating p300-mediated H3K18la binding to METTL3 promoter site. The METTL3-mediated m6A enriched ACSL4, its mRNA stability regulated through YTHDC1-dependent pathway. Furthermore, short-term stimulation upregulates which promotes mitochondria-associated ferroptosis. Inhibition knockdown or targeted inhibition effectively suppresses septic hyper-lactate-induced ferroptosis alveolar epithelial cells mitigates mice. Our findings suggest induces via GPR81/H3K18la/METTL3/ACSL4 axis during ALI. These results reveal histone lactylation-driven mechanism inducing modification. Targeting represents promising therapeutic strategy for patients

Language: Английский

Citations

38
Xanthium strumarium/gelatin methacryloyl based hydrogels with anti-inflammatory and antioxidant properties for diabetic wound healing via akt/mtor pathway DOI
Zixuan Zhao, Shuyan Han,

Wei-Guo Feng

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 300, P. 140186 - 140186

Published: Jan. 27, 2025

Language: Английский

Citations

5
Role of mitochondria in the regulation of ferroptosis and disease DOI Creative Commons
Cheng Fu, Nan Cao,

Sen Zeng

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Dec. 13, 2023

Ferroptosis is a distinctive form of iron-dependent cell death characterized by significant ultrastructural changes in mitochondria. Given the crucial involvement mitochondria various cellular processes such as reactive oxygen species production, energy metabolism, redox status, and iron mounting evidence suggests vital role regulation execution ferroptosis. Furthermore, there exists strong correlation between ferroptosis diseases. In this review, we aim to summarize mechanisms underlying induction defense ferroptosis, emphasizing influence on intricate process. Additionally, provide an overview disease, particularly cancer, elucidate which drugs targeting impact By presenting theoretical foundation reference point, review aims contribute both basic biology research investigation clinically relevant

Language: Английский

Citations

27
Ovarian aging: energy metabolism of oocytes DOI Creative Commons
Shenglan Bao, Tailang Yin,

Su Liu

et al.

Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)

Published: May 31, 2024

Abstract In women who are getting older, the quantity and quality of their follicles or oocytes decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, lower oocytes. As more choose to delay childbirth, decline in fertility associated with age has become a significant concern for modern women. The oocyte key indicator aging. Many studies suggest that age-related changes energy metabolism may impact quality. Changes affect adenosine 5'-triphosphate (ATP) production, but how related products proteins influence remains largely unknown. review focuses on aging its potential quality, as well therapeutic strategies partially metabolism. research aims enhance our understanding metabolism, identification biomarkers treatment methods.

Language: Английский

Citations

14
The crosstalk between oncogenic signaling and ferroptosis in cancer DOI

Qianghu Pang,

Zhirou Tang,

Lianxiang Luo

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 197, P. 104349 - 104349

Published: April 16, 2024

Language: Английский

Citations

11
TaoHe ChengQi decoction ameliorates sepsis-induced cardiac dysfunction through anti-ferroptosis via the Nrf2 pathway DOI

Si-min Lu,

Bo Yang,

Zhang‐Bin Tan

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155597 - 155597

Published: April 21, 2024

Language: Английский

Citations

9
Carbon nanoparticles-Fe(II) complex combined with sorafenib for ferroptosis-induced antitumor effects in triple-negative breast cancer DOI
Ping Xie, Ting Qu, Kexin Tang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114562 - 114562

Published: Feb. 12, 2025

Language: Английский

Citations

1
The Regulation of Trace Metal Elements in Cancer Ferroptosis DOI Creative Commons

Xiaoyan Wang,

Yuanyuan Xue, Lei Chang

et al.

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.

Language: Английский

Citations

1