Luteolin: A promising multifunctional natural flavonoid for human diseases

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3417 - 3443

Published: April 26, 2024

Abstract Natural products are closely associated with human health. Luteolin (LUT), a flavonoid polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It noteworthy that LUT exhibits variety of beneficial pharmacological properties holds significant potential for clinical applications, particularly antitumor, anti‐convulsion, diabetes control, anti‐inflammatory, neuroprotection, anti‐oxidation, anti‐cardiovascular, other aspects. The mechanism action has been partially elucidated, including the mediation NF‐κB, toll‐like receptor, MAPK, Wnt/β‐catenin, PI3K/Akt, AMPK/mTOR, Nrf‐2, among others. review aimed to comprehensively consolidate essential information on natural sources, effects, therapeutic preventive potential, as well mechanisms LUT. objective establish theoretical basis continued development application

Language: Английский

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Iron/ROS/Itga3 mediated accelerated depletion of hippocampal neural stem cell pool contributes to cognitive impairment after hemorrhagic stroke

Redox Biology, Journal Year: 2024, Volume and Issue: 71, P. 103086 - 103086

Published: Feb. 13, 2024

Hemorrhagic stroke, specifically intracerebral hemorrhage (ICH), has been implicated in the development of persistent cognitive impairment, significantly compromising quality life for affected individuals. Nevertheless, precise underlying mechanism remains elusive. Here, we report first time that accumulation iron within hippocampus, distal to site ICH striatum, is causally linked observed impairment with both clinical patient data and animal model. Both susceptibility-weighted imaging (SWI) quantitative susceptibility mapping (QSM) demonstrated significant hippocampus patients, which far from actual hematoma. Logistical regression analysis multiple linear identified level as an independent risk factor a negative correlation post-ICH impairment. Using mouse model ICH, triggers excessive activation neural stem cells (NSCs). This overactivation subsequently leads depletion NSC pool, diminished neurogenesis, onset progressive dysfunction. Mechanistically, elevated levels reactive oxygen species (ROS), downregulated expression Itga3. Notably, pharmacological chelation or scavenger aberrant ROS levels, well conditionally overexpressed Itga3 NSCs, remarkably attenuated exhaustion abnormal neurogenesis decline ICH. Together, these results provide molecular insights into ICH-induced shedding light on value maintaining pool preventing dysfunction patients hemorrhagic stroke related conditions.

Language: Английский

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Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 2, 2024

Abstract Neurodegenerative diseases, characterized by progressive neuronal dysfunction and loss, pose significant health challenges. Glutamate accumulation contributes to cell death in diseases such as Alzheimer's disease. This study investigates the neuroprotective potential of Albizia lebbeck leaf extract its major constituent, luteolin, against glutamate-induced hippocampal death. Glutamate-treated HT-22 cells exhibited reduced viability, altered morphology, increased ROS, apoptosis, which were attenuated pre-treatment with A. luteolin. Luteolin also restored mitochondrial function, decreased superoxide, preserved morphology. Notably, we first found that luteolin inhibited excessive process mitophagy via inactivation BNIP3L/NIX lysosomal activity. Our suggests autophagy-mediated is activation mTORC1. These findings highlight a agent, inhibiting neurotoxicity regulating autophagy dynamics.

Language: Английский

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Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 124 - 124

Published: Feb. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Language: Английский

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The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102084 - 102084

Published: Oct. 5, 2023

Language: Английский

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Luteolin for neurodegenerative diseases: a review

Pharmacological Reports, Journal Year: 2024, Volume and Issue: 76(4), P. 644 - 664

Published: June 21, 2024

Neurodegenerative diseases such as Parkinson's disease, Alzheimer's Huntington's and multiple sclerosis affect millions of people around the world. In addition to age, which is a key factor contributing development all neurodegenerative diseases, genetic environmental components are also important risk factors. Current methods treating mostly symptomatic do not eliminate cause disease. Many studies focus on searching for natural substances with neuroprotective properties that could be used an adjuvant therapy in inhibition neurodegeneration process. These compounds include flavonoids, luteolin, showing significant anti-inflammatory, antioxidant, activity. Increasing evidence suggests luteolin may confer protection against neurodegeneration. this review, we summarize scientific reports from preclinical vitro vivo regarding beneficial effects diseases. Luteolin was studied most extensively various models disease but there several its Though very limited, possible protective discussed here. Overall, although show potential benefits disorders, clinical therapeutic efficacy still deficient.

Language: Английский

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Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease

Redox Biology, Journal Year: 2024, Volume and Issue: 71, P. 103105 - 103105

Published: March 4, 2024

Cognitive dysfunction can occur both in normal aging and age-related neurological disorders, such as mild cognitive impairment Alzheimer's disease (AD). These disorders have few treatment options due to side effects limited efficacy. New approaches slow decline are urgently needed. Dietary interventions (nutraceuticals) received considerable attention because they exhibit strong neuroprotective properties may help prevent or minimize AD symptoms. Biological is driven by a series of interrelated mechanisms, including oxidative stress, neuroinflammation, neuronal apoptosis, autophagy, which function through various signaling pathways. Recent clinical preclinical studies shown that dietary small molecules derived from natural sources, flavonoids, carotenoids, polyphenolic acids, modulate damage, impairments, mitochondrial dysfunction, autophagy dysregulation, gut microbiota dysbiosis. This paper reviews research on different their bioactive constituents the AD. Additionally, chemical structure, effective dose, specific molecular mechanisms action comprehensively explored. also discusses advantages using nanotechnology-based drug delivery, significantly enhances oral bioavailability, safety, therapeutic effect, lowers risk adverse effects. agents potential novel safe combat

Language: Английский

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The role of mitochondrial remodeling in neurodegenerative diseases

Neurochemistry International, Journal Year: 2025, Volume and Issue: unknown, P. 105927 - 105927

Published: Jan. 1, 2025

Language: Английский

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Investigation into Alzheimer's-related amyloid-β conformational transformations and stability influenced by green iron oxide nanoparticles (GIONP)

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 140124 - 140124

Published: Jan. 20, 2025

Language: Английский

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Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

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