Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

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18β-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134319 - 134319

Published: April 21, 2024

Language: Английский

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The Therapeutic Mechanisms of Mesenchymal Stem Cells in MS—A Review Focusing on Neuroprotective Properties

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1365 - 1365

Published: Jan. 23, 2024

In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress compartmentalized inflammation within central nervous system (CNS) and promote remyelination regeneration. Mesenchymal stem cells (MSCs) represent promising therapeutic option, as they have been shown migrate site of CNS injury exert neuroprotective properties, including immunomodulation, neurotrophic factor secretion, endogenous neural cell stimulation. This review summarizes current understanding underlying mechanisms discusses translation MSC transplantation their derivatives from pre-clinical demyelinating models clinical trials MS patients.

Language: Английский

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The Syvn1 inhibits neuronal cell ferroptosis by activating Stat3/Gpx4 axis in rat with spinal cord injury

Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(10)

Published: May 27, 2024

Abstract Spinal cord injury (SCI) leads to secondary neuronal death, which severely impedes recovery of motor function. Therefore, prevention cell death after SCI is an important strategy. Ferroptosis, a new form discovered in recent years, has been shown be involved the regulation SCI. However, role and potential mechanisms ferroptosis are not fully understood. In this study, we report that E3 ubiquitin ligase Syvn1 suppresses promotes functional from vitro vivo. Mechanistically, screened with bioinformatics, immunoprecipitation, mass spectrometry, identified Stat3, transcription factor induces expression inhibitor Gpx4, as substrate Syvn1. Furthermore, neurons primary cellular source signalling. Moreover, determined binding domains Stat3 HEK 293 T cells using full‐length proteins series truncated Flag‐tagged Myc‐tagged fragments. created animal models silencing or overexpression found inhibits by stabilizing subsequently activates regulator Gpx4 summary, Syvn1‐mediated Stat3/Gpx4 signalling axis attenuates ferroptosis, reduces repair. our findings provide targets intervention strategies for treatment

Language: Английский

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Punicalagin inhibits neuron ferroptosis and secondary neuroinflammation to promote spinal cord injury recovery

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114048 - 114048

Published: Jan. 18, 2025

Language: Английский

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Exosomal lncRNA RMRP-shuttled by Olfactory Mucosa-Mesenchymal Stem Cells Suppresses Microglial Pyroptosis to Improve Spinal Cord Injury via EIF4A3/SIRT1

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

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Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Pulmonary hypertension (PH) stands as a tumor paradigm cardiovascular disease marked by hyperproliferation of cells and vascular remodeling, culminating in heart failure. Complex genetic epigenetic mechanisms collectively contribute to the disruption pulmonary homeostasis. In recent years, advancements research technology have identified numerous gene deletions mutations, addition bone morphogenetic protein receptor type 2, that are closely associated with remodeling process PH. Additionally, modifications such RNA methylation, DNA histone modification, noncoding RNAs been shown precisely regulate PH molecular networks cell-type-specific manner, emerging potential biomarkers therapeutic targets. This review summarizes analyzes roles currently genes factors PH, emphasizing pivotal role long ncRNAs its regulation. it examines current clinical preclinical therapies for targeting these explores new treatment strategies.

Language: Английский

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SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch

Bone Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 14, 2025

Language: Английский

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Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 7, 2025

Stroke is characterized with high morbidity, mortality and disability all over the world, one of its core pathologies blood-brain barrier (BBB) dysfunction. BBB plays a crucial physiological role in protecting brain tissues maintaining homeostasis central nervous system (CNS). dysfunction serves as key factor development cerebral edema, inflammation, further neurological damage stroke patients. Currently, stem cells their derived exosomes have shown remarkable potential repairing damaged improving function after stroke. Stem repair integrity through anti-inflammatory, antioxidant, angiogenesis regulation intercellular signaling mechanisms, while cell-derived exosomes, natural nanocarriers, enhance therapeutic effect by carrying active substances such proteins, RNAs miRNAs. This review will present latest research advances treatment, well challenges cell source, transplantation timing, dosage, route administration clinical application, aiming to discuss mechanisms for proposes future directions. are expected provide new strategies early diagnosis precise treatment stroke, promote breakthroughs field

Language: Английский

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Zinc ions regulate mitochondrial quality control in neurons under oxidative stress and reduce PANoptosis in spinal cord injury models via the Lgals3-Bax pathway

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 221, P. 169 - 180

Published: May 21, 2024

Language: Английский

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