Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(3), P. 406 - 414
Published: Sept. 1, 2024
Language: Английский
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(9), P. 899 - 899
Published: Sept. 5, 2024
The role of mitochondria in neurodegenerative diseases is crucial, and recent developments have highlighted its significance cell therapy. Mitochondrial dysfunction has been implicated various disorders, including Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, Huntington's diseases. Understanding the impact mitochondrial biology on these conditions can provide valuable insights for developing targeted therapies. This mini-review refocuses emphasizes potential therapies leveraging mesenchymal stem cells, embryonic induced pluripotent cell-derived secretions, extracellular vesicles. Mesenchymal cell-mediated transfer restoring health cells with dysfunctional mitochondria. Additionally, attention paid to gene-editing techniques such as mito-CRISPR, mitoTALENs, mito-ZNFs, DdCBEs ensure safety efficacy treatments. Challenges future directions are also discussed, possible tumorigenic effects off-target effects, disease targeting, immune rejection, ethical issues.
Language: Английский
Citations
3
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Abstract Topology and bioactive molecules are crucial for stimulating cellular tissue functions. To regulate the chronic wound microenvironment, mono‐assembly technology is employed to fabricate a radial egg white hydrogel loaded with lyophilized adipose tissue‐extracellular vesicles (radial EWH@L‐EVs). The architecture not only significantly modified gene expression of functional cells, but also achieved directional controlled release kinetics L‐EVs. Through synergy topographical inherent cues, EWH@L‐EVs effectively reduced intracellular oxidative stress promoted polarization macrophages toward an anti‐inflammatory phenotype during inflammatory phase. Afterward, facilitated centripetal migration proliferation fibroblasts endothelial cells as transitioned proliferative During latter remodeling phase, accelerated regeneration granulation tissue, angiogenesis, collagen deposition, thereby promoting reorganization wound. Compared gold standard scaffold, actively accommodated microenvironment via various functions throughout all stages diabetic healing. This can be attributed orientation topological structures molecules, which should considered utmost importance in engineering.
Language: Английский
Citations
2
Cell Proliferation, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Abstract The extracellular microenvironment encompasses the matrix, neighbouring cells, cytokines, and fluid components. Anomalies in can trigger aging a decreased differentiation capacity mesenchymal stem cells (MSCs). MSCs perceive variations firmness of matrix respond by regulating mitochondrial function. Diminished function is intricately linked to cellular aging, studies have shown that mitochondria‐lysosome contacts (M‐L contacts) regulate sustain equilibrium. Nonetheless, influence M‐L on MSC under varying stiffness remains unclear. In this study, utilizing single‐cell RNA sequencing atomic force microscopy, we further demonstrate reduced older individuals leads subsequent decline osteogenic ability. Mechanistically, augmented low exacerbate escalating oxidative stress peripheral division. Moreover, soft stiffness, cytoskeleton reorganization facilitates rapid movement lysosomes. inhibitor ML282 ameliorates reinstating network Overall, our findings confirm instigated disruption induced while also elucidating potential mechanism which Contact regulates homeostasis. Crucially, presents promise for anti‐aging strategies centred mitochondria, particularly realm cell therapy.
Language: Английский
Citations
1
Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(3), P. 406 - 414
Published: Sept. 1, 2024
Language: Английский
Citations
0