Regulated cell death in chronic kidney disease: current evidence and future clinical perspectives DOI Creative Commons
Kurt T. K. Giuliani,

Benjamin C. Adams,

Helen Healy

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 31, 2024

Chronic kidney disease (CKD) is the progressive loss of function/structure over a period at least 3 months. It characterised histologically by triad cell loss, inflammation and fibrosis. This literature review focuses on forms death that trigger downstream fibrosis, collectively called regulated (RCD) pathways. Discrete RCD have emerged as central mediators CKD pathology. In particular, pathways necrosis - including mitochondrial permeability transition pore (mPTP)-mediated necrosis, necroptosis, ferroptosis pyroptosis been shown to mediate pathology directly or through release danger signals pro-inflammatory response, further amplifying tissue injury in cellular process necroinflammation. Despite accumulating evidence pre-clinical models, no clinical studies yet targeted these modes human CKD. The summarizes recent advances our understanding CKD, looks inter-relations between (with emphasis propagation signals) for therapeutic targeting molecules prevent treat

Language: Английский

The uptake of extracellular vesicles: research progress in cancer drug resistance and beyond DOI

Luomeng Qian,

Pangzhou Chen,

Shiwu Zhang

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 79, P. 101209 - 101209

Published: Feb. 1, 2025

Language: Английский

Citations

3
Emerging Frontiers in acute kidney injury: The role of extracellular vesicles DOI
Sirui Li, Lan Zhou, Yu Huang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 149 - 170

Published: Feb. 18, 2025

Language: Английский

Citations

1
Frontier role of extracellular vesicles in kidney disease DOI Creative Commons
Bei Li, Qi Chen, Yifan Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 20, 2024

Language: Английский

Citations

6
Ferroptosis-Related Oxaliplatin Resistance in Multiple Cancers: Potential Roles and Therapeutic Implications DOI Creative Commons

Si-Jia Zhong,

Zihan Wang,

Jiaxi Yang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37613 - e37613

Published: Sept. 1, 2024

Oxaliplatin (OXA)-based therapy is effective in the treatment of multiple cancers. However, primary or acquired OXA resistance remains an emerging challenge for its clinical application. Ferroptosis iron-dependent mode cell death that has been demonstrated to play essential role chemoresistance many drugs, including OXA. In particular, dysregulation SLC7A11-GPX4, one major antioxidant systems ferroptosis, was found colorectal cancer (CRC) and hepatocellular carcinoma (HCC). addition, Nrf2, upstream regulator GPX4 other factors, also involved CRC HCC. Inhibition SLC7A11-GPX4 Nrf2 by genetic deletion pharmaceutical inhibition could significantly reverse resistance. Long noncoding RNA (lncRNA) participates ferroptosis cells. Specifically, LINC01134 promotes recruitment promoter GPX4, thereby exerting transcriptional regulation which eventually increases sensitivity HCC through upregulation ferroptosis. On hand, a novel lncRNA DACT3-AS1 sensitizes gastric cells miR-181a-5p/sirtuin 1(SIRT1)-mediated Therapies based on combination enhancers provide new therapeutic insights overcome present review, we current understanding ferroptosis-related resistance, highlight pathogenesis chemoresistance, summarize available therapies target enhancing

Language: Английский

Citations

5
The significance of ferroptosis in renal diseases and its therapeutic potential DOI Creative Commons

Mingzhu Jiang,

Shujun Wu,

Kun Xie

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35882 - e35882

Published: Aug. 1, 2024

Language: Английский

Citations

4
Fabry disease podocytes reveal ferroptosis as a potential regulator of cell pathology DOI Creative Commons
Andrea F. Wise,

Igaa Ari Krisnadevi,

Shoni Bruell

et al.

Kidney International Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

3
Urinary and Plasma miRNAs in the Early Detection of Acute Kidney Injury and Their Possible Role as Therapeutic Targets DOI Open Access
Anna Clementi,

Grazia Maria Virzì,

Claudio Ronco

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2306 - 2306

Published: March 28, 2025

Acute Kidney Injury (AKI) is a severe clinical condition featured by rapid decrease in kidney function short period of time. AKI, which often secondary to sepsis, ischemia-reperfusion and drug toxicity, associated high morbidity mortality. Moreover, it contributes the development chronic disease (CKD), due maladaptive or incomplete repair mechanisms, resulting renal fibrosis. Small non-coding RNA has recently emerged as novel biomarker for early detection treatment AKI. In particular, microRNAs (miRNAs) are molecules 21-25 nucleotides regulating expression protein-coding genes through sequence-specific recognition. Due their stability biological fluids, such urine plasma, they can be reliably analyzed quantified, this reason considered potential diagnostic therapeutic biomarkers. Specifically, miRNAs have been demonstrated predict AKI before increase creatinine levels, thus improving management syndrome. review, we provide comprehensive overview role urinary plasma

Language: Английский

Citations

0
A Novel Protocol for Culturing Polarized Proximal Tubular Epithelial Cells from Kidney Biopsies: Enhancing Platforms for Drug Excretion and Nephrotoxicity Studies DOI Creative Commons
Tadej Petreski, Lidija Gradišnik,

Luka Varda

et al.

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(2), P. 52 - 52

Published: April 1, 2025

The kidneys are integral to homeostasis but susceptible nephrotoxic compounds. Proximal tubular epithelial cells (PTECs) mediate drug metabolism and transport widely used in preclinical studies. However, commercial PTECs limited availability physiological relevance. This study aimed develop a novel, reliable protocol for isolating culturing from human kidney biopsies. Primary were isolated biopsies of two patients (MFUM-RPTEC-1 MFUM-RPTEC-2). Their morphology, population doubling time, transepithelial electrical resistance (TEER), phenotypic markers evaluated. Polarization transporter expression analyzed using cultured on Transwell inserts. Colonies formed within 24–48 h, with confluence reached by 8–10 days dome (hemicyst) formation day 13. TEER values peaked at 190 Ω/cm2 after 7–14 days, confirming tight junction formation. Immunostaining identified characteristic (e.g., SGLT2, OAT1/3, OCT2, P-gp, MRP4, MATE1, N-cadherin, ZO-1, CK-18). Cells plates exhibited native polarization, expressing transporters crucial excretion apical basolateral surfaces. We present robust protocols characterizing PTECs, offering scalable method obtain functional, polarized scarce biopsy material. therefore, valuable platform studies, especially testing through the expressed transporters. Drug competition these during secretion is also common cause nephrotoxicity.

Language: Английский

Citations

0
Molecular Mechanisms and Potential Therapeutic Targets of Ischemia–Reperfusion Injury in Kidney Transplantation DOI Creative Commons
Anjie Huang, Gaurav Kumar Sharma, Rohan Parikh

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 282 - 282

Published: April 17, 2025

End-stage renal disease (ESRD) is a serious and lethal that carries with it high morbidity mortality rate if left untreated. Treating ESRD conducted via replacement therapy and/or kidney transplantation, the latter being preferred option given better outcomes quality of life for patients. However, as rises in prevalence, transplantation rates remain largely unchanged. In every ischemia–reperfusion injury (IRI) inevitable effect this has on depends based donor type. IRI works through variety molecular mechanisms, primarily mitochondrial oxidative stress programmed cell death mechanisms. Given urgency to ensure best these limited transplants, there been continued effort find various potential therapeutic mechanisms counteract preoperatively, intraoperatively, postoperatively. These include hypothermic machine perfusion, ischemic conditioning, nanoparticle removal free radicals, peptide-based therapies, microRNA, more. There an ongoing way mitigate achieved understanding IRI.

Language: Английский

Citations

0
Renal Health Through Medicine–Food Homology: A Comprehensive Review of Botanical Micronutrients and Their Mechanisms DOI Open Access
Yi Zhao,

Jian‐Ye Song,

Ru Feng

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3530 - 3530

Published: Oct. 18, 2024

As an ancient concept and practice, "food as medicine" or "medicine-food homology" is receiving more attention these days. It a tradition in many regions to intake medicinal herbal food for potential health benefits various organs systems including the kidney. Kidney diseases usually lack targeted therapy face irreversible loss of function, leading dialysis dependence. most important organ endogenous metabolite exogenous nutrient excretion, status kidney could be closely related daily diet. Therefore, rich antioxidative, anti-inflammation micronutrients are ideal supplements protection. Recent studies have also discovered its impact on "gut-kidney" axis.

Language: Английский

Citations

1