PRDX1 knockdown promotes erastin-induced ferroptosis and impedes diffuse large B-cell lymphoma development by inhibiting the MAPK/ERK pathway

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 30, 2025

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and DLBCL cells are highly sensitive to ferroptosis. The purpose of this research was evaluate the role molecular mechanism peroxiredoxin 1 (PRDX1) on ferroptosis in DLBCL. expression PRDX1 tissues detected using bioinformatics analysis reverse transcription quantitative PCR. impacts cell proliferation, apoptosis, migration, invasion, were assessed through a series vitro experiments. A xenograft tumor model constructed verify roles vivo. Transcriptome sequencing conducted identify PRDX1-mediated signaling pathways. Anisomycin, agonist mitogen-activated protein kinase (MAPK), used explore modulation MAPK pathway. upregulated knockdown inhibited promoted suppressed growth. boosted erastin-induced by increasing levels iron MDA, while decreasing GSH. It also COX2 GPX4 SLC7A11 levels. reduced phosphorylation MEK ERK both under conditions with or without erastin induction. MAPK/ERK pathway anisomycin, significantly reversed inhibitory effects malignant behaviors promotion facilitates obstacles progression inhibiting pathway, offering potential treatment strategy for treatment.

Language: Английский

Lipid Peroxidation-Related Redox Signaling in Osteosarcoma

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4559 - 4559

Published: April 22, 2024

Oxidative stress and lipid peroxidation play important roles in numerous physiological pathological processes, while the bioactive products of peroxidation, hydroperoxides reactive aldehydes, act as mediators redox signaling normal malignant cells. Many types cancer, including osteosarcoma, express altered pathways. Such pathways protect cancer cells from cytotoxic effects oxidative stress, thus supporting transformation, eventually anticancer therapies associated with stress. In this review, we aim to explore status osteosarcoma highlight involvement pathways, therapies.

Language: Английский

Dysregulated activation of Hippo-YAP1 signaling induces oxidative stress and aberrant development of intrahepatic biliary cells in biliary atresia

Laboratory Investigation, Journal Year: 2024, Volume and Issue: 105(2), P. 102199 - 102199

Published: Nov. 22, 2024

Language: Английский