Polycatechols inhibit ferroptosis and modulate tau liquid–liquid phase separation to mitigate Alzheimer's disease

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(13), P. 3082 - 3089

Published: Jan. 1, 2024

Polycatechols modulate amyloid-associated toxicities, arrest labile iron, inhibit lipid peroxidation, and regulate tau liquid–liquid phase separation (LLPS) to mitigate the pathological nexus between ferroptosis AD.

Language: Английский

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Ginger leaf polyphenols mitigate β-amyloid toxicity via JNK/FOXO pathway activation in Caenorhabditis elegans

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Ginger leaf polyphenols (GLP) alleviated β-amyloid toxicity by activating the JNK/FOXO signaling pathway in Caenorhabditis elegans .

Language: Английский

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Bioengineered Versatile Heterojunctions as Stress Busters Targeting Matrix Degradation and Ferroptosis for Osteoarthritis Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of articular cartilage, with the underlying mechanism being inability chondrocytes to maintain homeostasis in response changing stress. The stress triggered excess ROS from various factors critical regulating chondrocyte survival and fate. In this study, 2D Mo 4/3 B 2‐ X MBene cerium‐gallic acid metal‐polyphenol network (MPN) together cartilage‐targeted shell hyaluronic WYRGRL (HW) are utilized development bio‐heterojunction MBene@MPN‐HW (MBM‐HW) through self‐assembly. MBM‐HW not only demonstrates superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) enzyme mimicking capabilities effectively scavenge ROS, but also exhibits dual‐responsive release cartilage‐targeting properties. Importantly, both vivo vitro experiments indicate that could alleviate oxidative stress, protect mitochondrial function, suppress cartilage matrix ferroptosis, thereby slowing progression OA. Mechanistically, it demonstrated attenuate Perk/eIF2α cascade mediated integrated restrain maintaining homeostasis. Overall, work underscores robust stress‐relieving capacity MBM‐HW, providing novel approach for treatment

Language: Английский

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Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 265 - 265

Published: Feb. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Language: Английский

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The Use of Natural Volatile Compounds on the Fibrillation Domain of Amyloid Beta (GSNKGAIIGLM)─Towards Promising Agents to Combat Alzheimer’s Disease

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Alzheimer's disease (AD), which is caused by the accumulation of amyloid-beta, a major medical concern today. Controlling these aggregates critical to drug development, but delivering them effectively into bloodstream poses significant challenges. In this context, aromatherapy has been proposed as an innovative and promising approach for AD disease. The volatile compounds cinnamaldehyde, phenylethyl alcohol, α-asarone, β-caryophyllene have neuroprotective effects that can be effective in treatment neurodegenerative diseases like AD. amyloid-beta (Aβ) fragment (25–35), retains properties full-length Aβ used suitable model evaluate potential toxicity associated with This study investigated four mentioned at different concentrations on fibrillation process (25–35) peptide. Structural changes peptide analyzed using various techniques such fluorescence probing, far-UV circular dichroism spectroscopy (CD), atomic force microscopy (AFM). Fluorescence probing results showed prevent formation amyloid fibrils forming chemical bonds intermediate species. CD indicated decrease β-sheet content confirmed effect pH structural changes. AFM analysis revealed prevented changed average size intermediates oligomeric These findings show future patients emphasize importance natural prevention diseases.

Language: Английский

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Investigating the therapeutic potential of 1,2,3,4,6 penta-O-galloyl-β-D-glucose in Alzheimer’s disease: a scoping review

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: March 17, 2025

The gallotannin 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose (β-PGG) has recently garnered scientific interest due to its potent antioxidant, anti-inflammatory and neuroprotective properties. Alzheimer's disease (AD), a neurodegenerative disorder marked by neuroinflammation, oxidative stress, cholinergic dysfunction, accumulation of amyloid β (Aβ), tau metal ions, may benefit from β-PGG interventions. This review synthesises existing literature explore the therapeutic potential in AD. Experimental evidence suggests that can suppress pro-inflammatory mediator release inhibit NF-κB MAPK signalling pathways, both critical AD progression. In vitro studies highlight β-PGG's ability scavenge free radicals, enhance antioxidant enzyme function, prevent lipid peroxidation, well-known phenomena Additionally, neuroprotection be conferred capacity reduce ion accumulation, Aβ aggregation, modulate neurotransmission vitro. summary, while shows promise targeting hallmarks vitro, further vivo are crucial validate potential.

Language: Английский

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Saponins from Astragalus membranaceus (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer’s Disease by Regulating the NOX4/Nrf2 Signaling Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Alzheimer's disease (AD) is a chronic neurodegenerative of the central nervous system caused by loss neuronal or myelin function, accompanied ferroptosis. Astragalus membranaceus (Fisch.) Bge. (A. membranaceus) one China's homologous lists medicines and food, its active component saponins have neuroprotective effects. This study examines mechanism from A. (AS) in treating AD. UPLC-Q-TOF-MS analyzed composition AS. Ferroptosis models were established to evaluate anti-AD efficacy. As result, AS treatment inhibited ferroptosis SAMP8 mice restoring iron homeostasis lipid peroxidation (LPO) balance brain, thereby improving cognitive impairment pathological damage. Mechanistically, reduced Fe2+, MDA, ROS levels enhanced protein SLC7A11, GPX4, FTH1, FPN1. NADPH oxidase 4 (NOX4) overexpression revealed that NOX4, reducing NOX4 stability regulating NOX4/Nrf2 pathway erastin-injured HT22 cells significantly alleviating Therefore, improved AD rebuilding LPO brain. has potential be promising candidate medicine for

Language: Английский

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Analysis of human brain RNA-seq data reveals combined effects of 4 types of RNA modifications and 18 types of programmed cell death on Alzheimer’s disease

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 3, 2025

Language: Английский

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Anti-Alzheimer effects of an HDAC6 inhibitor, WY118, alone and in combination of lithium chloride: Synergistic suppression of ferroptosis via the modulation of tau phosphorylation and MAPK signaling

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177605 - 177605

Published: April 1, 2025

Language: Английский

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A multifunctional theranostic agent based on rhodamine-modified copper-gallic acid nanoparticles targeting Alzheimer’s β‑amyloid species

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163063 - 163063

Published: April 1, 2025

Language: Английский

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