Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 73, P. 107694 - 107694
Published: April 14, 2025
Language: Английский
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 947, P. 174445 - 174445
Published: July 7, 2024
Language: Английский
Citations
20
Environmental Pollution, Journal Year: 2020, Volume and Issue: 268, P. 115364 - 115364
Published: Aug. 20, 2020
Language: Английский
Citations
92
Andrologia, Journal Year: 2020, Volume and Issue: 53(1)
Published: May 24, 2020
The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation the associated discharge an excess synthetic substances into environment. Humans are inevitably exposed to these ubiquitously distributed environmental contaminants, which possess ability intervene growth function reproductive organs. Several epidemiological reports blood seminal levels contaminants poor quality. Numerous vivo vitro studies conducted investigate effect various on spermatogenesis, steroidogenesis, Sertoli cells, blood-testis barrier, epididymis functions. reported reprotoxic effects include alterations spermatogenic cycle, increased germ cell apoptosis, inhibition decreased Leydig viability, impairment structure function, altered expression steroid receptors, permeability induction peroxidative epigenetic spermatozoa resulting function. In light recent scientific reports, this review discusses possible mechanisms action.
Language: Английский
Citations
89
Frontiers in Environmental Science, Journal Year: 2021, Volume and Issue: 9
Published: July 15, 2021
Phthalate esters (PEs) are by far the most produced and extensively used synthetic organic chemicals with notable applications in many industrial products such as vinyl upholstery, adhesives, food containers, packaging materials, printing inks, cosmetics, paints, pharmaceuticals munitions, insecticides among other. PEs have long been recognised ubiquitous pollutants of prime environmental concern, urbanisation amongst main cause source these compounds. Due to their notoriety, compounds known pose devastating effects living organisms including humans. The presence metabolites aquatic ecosystems is concern primarily due endocrine disrupting carcinogenicity properties. Several research studies reported prevalence, exposure pathways, toxicity, impacts Their principal routes could be direct or indirect, which route include contact, eating, drinking contaminated foods, indirect constitute aerosols, leaching other forms contamination. find way into water systems through means effluent discharges, urban agricultural land runoff, from waste dumps diffuse sources. High-end instrumentation improved methodologies on hand resulted increased ability measure trace levels (μg/L) different matrices ecological compartments lakes, oceans, rivers, sediments, wetlands samples. In light above, this article provides an informed focused information prevalence phthalate related Furthermore, techniques that enabled extraction analysis samples also explained. Future outlooks needs highlighted manuscript. This will better understand temporal spatial distributions aid devising prudent curtail footprints.
Language: Английский
Citations
67
Environmental Pollution, Journal Year: 2022, Volume and Issue: 310, P. 119918 - 119918
Published: Aug. 8, 2022
Language: Английский
Citations
65
Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 108, P. 104457 - 104457
Published: April 25, 2024
Phthalate esters (PAEs) are widely used as plasticizers to enhance the flexibility and durability of different consumer products, including clothing. However, concerns have been raised about potential adverse health effects associated with presence phthalates in textiles, such endocrine disruption, reproductive toxicity carcinogenicity. Based on examination more than 120 published articles, this paper presents a comprehensive review studies concerning phthalate content clothing other textile special emphasis those conducted last decade (2014-2023). The types role PAEs plasticizers, relevant legislation countries (emphasizing importance monitoring PAE levels protect health) analytical methods for determination critically evaluated. also discusses models evaluate exposure risks. Finally, study limitations challenges related determining contents products considered.
Language: Английский
Citations
10
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Feb. 26, 2024
Humans and wildlife, including domesticated animals, are exposed to a myriad of environmental contaminants that derived from various human activities, agricultural, household, cosmetic, pharmaceutical, industrial products. Excessive exposure pesticides, heavy metals, phthalates consequently causes the overproduction reactive oxygen species. The equilibrium between species antioxidant system is preserved maintain cellular redox homeostasis. Mitochondria play key role in function cell survival. vulnerable damage can be provoked by exposures. Once mitochondrial metabolism damaged, it interferes with energy eventually free radicals. Furthermore, also perceives inflammation signals generate an inflammatory response, which involved pathophysiological mechanisms. A depleted provokes oxidative stress triggers regulates epigenetic apoptotic events. Apart that, these chemicals influence steroidogenesis, deteriorate sperm quality, male reproductive organs. It strongly believed signaling molecules regulators mediate toxicity. This review article aims spotlight toxicology on reproduction its fertility prognosis. we shed light modulating response toxins function. Additionally, emphasize supporting evidence diverse animal studies.
Language: Английский
Citations
9
Environmental Pollution, Journal Year: 2019, Volume and Issue: 257, P. 113517 - 113517
Published: Nov. 15, 2019
Language: Английский
Citations
65
Environment International, Journal Year: 2020, Volume and Issue: 138, P. 105627 - 105627
Published: March 6, 2020
Over the past few decades, accumulated evidence confirms that global environment conditions are changing rapidly. Urban industrialization, agriculture and globalization have generated water, air soil pollution, giving rise to an with a growing number of stress factors, which has serious impact on fitness, reproduction survival living organisms. The issue raises considerable concern biodiversity conservation, is now at risk: it estimated species will be extinct in near future. Sexual process allows formation new individual underpinned by gamete quality defined as ability spermatozoa oocytes interact during fertilization leading creation development normal embryo. This review aimed provide current state knowledge regarding broad spectrum environmental stressors diverse parameters used estimate evaluate humans canonical animal models for experimental research. Effects metals, biocides, herbicides, nanoparticles, plastics, temperature rise, ocean acidification, pollution lifestyle physiological underlie competence described supporting concept represent hazard reproductive disorders organism failure. Although clear still limited, capacity maintain and/or recover recently demonstrated providing further clues about plasticity organisms their tolerance pressures may facilitate persistence within scenario change. Changes must urgently placed forefront public attention, massive effort invested studies towards implementing identifying methodologies markers predict impairment quality.
Language: Английский
Citations
64
Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)
Published: March 4, 2019
A temporal decline in human and dog sperm quality is thought to reflect a common environmental aetiology. This may direct effects of seminal chemicals on function quality. Here we report the diethylhexyl phthalate (DEHP) polychlorinated biphenyl 153 (PCB153) DNA fragmentation motility sperm. Human semen was collected from registered donors (n = 9) stud dogs 11) incubated with PCB153 DEHP, independently combined, at 0x, 2x, 10x 100x testis concentrations. total 16 treatments reflected 4 × factorial experimental design. Although exposure DEHP and/or alone increased decreased motility, scale dose-related varied presence relative concentrations each chemical (DEHP.PCB interaction for: fragmentation; p < 0.001, 0.001; Motility; 0.05). In both sperm, progressive negatively correlated regardless (Human: P 0.0001, r -0.36; -0.29). We conclude that PCB153, known tissue concentrations, induce similar supporting contention as sentinel species for exposure.
Language: Английский
Citations
55