Do (xeno)estrogens pose a risk to earthworms? Soy isoflavones and estradiol impact gonad structure and induce oxidative stress in Eisenia fetida DOI Creative Commons
Tiago Azevedo, Rita Silva‐Reis, Beatriz Medeiros‐Fonseca

et al.

Chemosphere, Journal Year: 2025, Volume and Issue: 377, P. 144315 - 144315

Published: March 28, 2025

Understanding the impact of endocrine disruptor compounds (EDCs) across a wide range species is crucial, given their ubiquitous presence. Although invertebrate lack sex steroid hormone pathways, they exhibit sensitivity to EDCs, which could affect population dynamics. This study assessed reproductive endpoints and oxidative stress parameters in Eisenia fetida following exposure estradiol soy isoflavones, resembling concentrations found livestock manure. The experiment used artificial soil, as recommended by OECD guidelines (7:2:1 sand, kaolin peat). Adult specimens were randomly divided into seven groups (n = 11/replicate): one control, three (156.1, 283.4 633.8 μg/kg dry soil) isoflavones (113.0, 215.3 405.0 mg/kg concentrations. After eight weeks, samples collected for cytological, histological biochemical analysis. Offspring development was after 12 additional weeks. Higher isoflavone led lower germ cell number increased abnormalities, especially seminal vesicles ovaries. Catalase peroxidase activities significantly all treated groups. did not E. offspring. These findings highlight fetida's EDCs at tissue level, suggesting its use bioindicator assessing EDC contamination soils.

Language: Английский

Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids DOI Creative Commons
Inge Varik, Runyu Zou, Andrea Bellavia

et al.

Environment International, Journal Year: 2024, Volume and Issue: 191, P. 108960 - 108960

Published: Aug. 15, 2024

The plasticizer di(2-ethylhexyl) phthalate (DEHP) is known to have endocrine-disrupting properties mediated by its many metabolites that form upon exposure in biological systems. In a previous study, we reported an inverse association between DEHP the human ovarian follicular fluid (FF) and responsiveness of follicles controlled stimulation during vitro fertilization (IVF) treatments. Here, explored this further through molecular analysis FF samples. Ninety-six IVF patients from Swedish (N = 48) Estonian infertility clinics were selected cohort 333) based on molar sum their samples arrive at "high" (mean 7.7 ± SD 2.3 nM, N "low" (0.8 0.4 groups. Extracellular miRNA levels concentrations 15 steroid hormones measured across addition, somatic cells, available for patients, used RNA sequencing. Differential expression (DE) interactions mRNA networks revealed genes cholesterol biosynthesis steroidogenesis pathways significantly decreased high compared low group. DE miRNAs predicted target key enzymes within these (FDR < 0.05). A 17-OH-progesterone progesterone ratio was observed group (p Additionally, associated with inflammatory processes elevated computational cell-type deconvolution suggested increased immune cell infiltration into conclusion, altered milieu ovaries, involving pro-inflammatory environment reduced metabolism, including synthesis. These results contribute our understanding mechanisms female reprotoxic effects DEHP.

Language: Английский

Citations

5
Multi- and Transgenerational Effects of Environmental Toxicants on Mammalian Reproduction DOI Creative Commons
Paola Rebuzzini, Gemma Fabozzi, Danilo Cimadomo

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(19), P. 3163 - 3163

Published: Oct. 9, 2022

Environmental toxicants (ETs) are an exogenous chemical group diffused in the environment that contaminate food, water, air and soil, through food chain, they bioaccumulate into organisms. In mammals, exposure to ETs can affect both male female fertility their reproductive health complex alterations impact gametogeneses, among other processes. humans, direct concurs declining of fertility, its transmission across generations has been recently proposed. However, multi- transgenerational inheritances ET reprotoxicity have only demonstrated animals. Here, we review recent studies performed on laboratory model animals investigating effects ETs, such as BPA, phthalates, pesticides persistent contaminants, system transmitted generations. This includes multigenerational effects, where compounds cannot be excluded, unexposed Additionally, report epigenetic mechanisms, DNA methylation, histone tails noncoding RNAs, which may play a mechanistic role nongenetic environmental information germline

Language: Английский

Citations

20
Does the environment affect menopause? A review of the effects of endocrine disrupting chemicals on menopause DOI
Leonard Levine, Janet E. Hall

Climacteric, Journal Year: 2023, Volume and Issue: 26(3), P. 206 - 215

Published: April 3, 2023

Endocrine disrupting chemicals are widely distributed in our environment. Humans exposed to these compounds not only through their occupations, but also dietary consumption and exposure contaminated water, personal care products textiles. Chemicals that persistent the body environment include dioxins polychlorinated biphenyls. Non-persistent including bisphenol A, phthalates parabens equally as important because they ubiquitous Heavy metals, lead cadmium, can have endocrine properties. Although difficult study due variety of sources exposures mechanisms action, been associated with early menopause, increased frequency vasomotor symptoms, altered steroid hormone levels markers diminished ovarian reserve. Understanding impacts is given potential for epigenetic modification, which alter gene function result multi-generational effects. This review summarizes findings humans animals or cell-based models from past decade research. Continued research needed assess effects mixtures chemicals, chronic new continuously being developed replacements toxic phased out.

Language: Английский

Citations

12
WITHDRAWN: Phthalate intake in Chinese homes and its contribution to total intake among children DOI

Yeganeh Ataei,

Yuexia Sun,

Changqi Zhu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract The full text of this preprint has been withdrawn by the authors while they make corrections to work. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.

Language: Английский

Citations

0
Associations between urinary and follicular fluid concentrations of phthalate metabolites and reproductive outcomes in Brazilian women undergoing fertility treatment DOI
Carla Giovana Basso, Bruno Alves Rocha,

Ivana Rippel Hauer

et al.

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108868 - 108868

Published: Feb. 1, 2025

Language: Английский

Citations

0
Valorization of CNSL as a Sustainable Solution for PVC Plasticization: A Comprehensive Study of Cardanol–Cardol Mixture DOI Creative Commons

Adélaïde Gartili,

Vincent Lapinte, Benoît Briou

et al.

Journal of the American Oil Chemists Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

ABSTRACT For the first time, a mixture of cardanol and cardol esters has been studied as plasticizers for PVC. From our previous work, it established that favorable plasticizing properties PVC materials exist. Hence, utilization cashew nutshell liquid (CNSL), naturally occurring cardol, plasticizer presents an intriguing prospect. While major studies focused on cardanol‐based plasticizers, their extraction process entails time‐consuming, energy‐intensive, costly steps, thereby limiting market competitiveness. The aim this study is not to focus pure or cardanol, previously conducted, but instead derived mixtures obtained through CNSL extraction. Various ester with different alkyl length chains were synthesized from various mixtures, containing ratios cardol. chemical structure these was fully characterized by using 1 H NMR spectroscopy, while rheological plastisol, mechanical properties, thermal stability plasticized films investigated. Through exploration, insights into potential CNSL‐derived efficient are elucidated, offering promising alternatives reduced processing complexities enhanced viability.

Language: Английский

Citations

0
Association of prenatal phthalate exposure with pubertal development in Spanish boys and girls DOI
Carmen Freire, Francesca Castiello, María-José López-Espinosa

et al.

Environmental Research, Journal Year: 2022, Volume and Issue: 213, P. 113606 - 113606

Published: June 15, 2022

Language: Английский

Citations

17
Evaluating associations of bisphenol and phthalate exposure with time to pregnancy and subfecundity in a New York City pregnancy cohort DOI
Mia Charifson,

Eunsil Seok,

Yuyan Wang

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 356, P. 124281 - 124281

Published: June 1, 2024

Language: Английский

Citations

3
The Effect of Various Environmental Pollutants on the Reproductive Health in Children: A Brief Review of the Literature DOI Creative Commons
Özge Yeşildemir,

Mensure Nur Celik

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(3), P. 382 - 392

Published: June 27, 2024

Abstract Purpose of Review Environmental pollutants in air, water, soil, and food are a significant concern due to their potential adverse effects on fetuses, newborns, babies, children. These chemicals, which pass fetuses babies through trans-placental transfer, breast milk, infant formula, dermal non-nutritive ingestion, can cause health problems during childhood. This review aims discuss how exposure various environmental early life stages disrupt reproductive Recent Findings affect Leydig cell proliferation differentiation, decreasing testosterone production throughout life. may result cryptorchidism, hypospadias, impaired semen parameters, reduced fertility. Although many studies female cannot be interpreted support causal relationships, critical windows subsequently induce diseases, including or delayed puberty, polycystic ovary syndrome, endometriosis, cancers. Summary There is growing evidence that fetal early-life could diet thought the primary route by humans exposed pollutants, there no adopted nutritional interventions reduce harmful children's health. Therefore, understanding impact contaminants outcomes inform design future human studies.

Language: Английский

Citations

3
Identifying pesticides of high concern for ecosystem, plant, animal, and human health: A comprehensive field study across Europe and Argentina DOI Creative Commons
Abdallah Alaoui, Florian Christ, Vera Silva

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174671 - 174671

Published: July 14, 2024

The widespread and excessive use of pesticides in modern agricultural practices has caused pesticide contamination the environment, animals, humans, with confirmed serious health consequences. This study aimed to identify 20 most critical substances based on an analysis detection frequency (DF) median concentrations (MC) across environmental biological matrices. A sampling campaign was conducted 10 case sites Europe 1 Argentina, each encompassing conventional organic farming systems. We analysed 209 active a total 4609 samples. All ranked among were detected silicon wristbands worn by humans animals indoor dust from both Five them all Overall, higher values DF MC, including blood plasma recorded samples compared farms. differences between systems greater less animal human Ten farms eight Two those, systems, are classified as hazardous for mammals (acute). seven (dietary). Three carcinogens. Seven endocrine disruptors. Six substances, which five plasma, reproduction/development. Efforts needed elucidate unknown effects mixtures, it is crucial that such research also considers biocides banned constitute baseline adds effect used agriculture.

Language: Английский

Citations

3