Toxicology Reports, Journal Year: 2024, Volume and Issue: unknown, P. 101885 - 101885
Published: Dec. 1, 2024
Language: Английский
Published: Jan. 1, 2024
Language: Английский
Citations
9
Animal Reproduction, Journal Year: 2023, Volume and Issue: 20(2)
Published: Jan. 1, 2023
Plastic pollution in our environment is one of the most important global health concerns right now. Micro- and nanoplastics (MNPs) are taken up by both humans animals, mainly via food water, can pass epithelial barriers. Indications plastics blood circulation have recently been shown farm but standardized methods to quantify exact levels MNPs which we exposed currently lacking. Potential hazards being investigated very recently, including impact that may on reproduction. However, studies mammalian reproduction scarce, a wealth data from aquatic species indicates reproductive effects MNPs. The first rodent models demonstrate reach gonads after oral exposure offspring maternal during gestational period. These arise particles themselves or presence plastic contaminants leach plastics. contamination has detected human placentas, fetal fluid meconium newborns, indicating start life. Currently there lack investigate MNP periconception embryonic period, whereas this an extremely sensitive period needs considerable attention with growing amount environment.
Language: Английский
Citations
20
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 923, P. 170949 - 170949
Published: Feb. 15, 2024
The herbicide linuron can cause endocrine disrupting effects in Xenopus tropicalis frogs, including offspring that were never exposed to the contaminant. mechanisms by which these are transmitted across generations need be further investigated. Here, we examined transgenerational alterations of brain and testis DNA methylation profiles paternally inherited from grandfathers developmentally an environmentally relevant concentration linuron. Reduced representation bisulfite sequencing (RRBS) revealed numerous differentially methylated regions (DMRs) (3060 DMRs) (2551 adult male F2 generation. Key genes involved somatotropic (igfbp4) thyrotropic signaling (dio1 tg) correlated with phenotypical body size, weight, hind limb length plasma glucose levels, indicating changes could potential mediators Testis DMRs found essential for spermatogenesis, meiosis germ cell development (piwil1, spo11 tdrd9) their levels number cells nests per seminiferous tubule, endpoint disrupted spermatogenesis. also identified several central machinery regulates epigenetic landscape (dnmt3a mbd2) histone acetylation (hdac8, ep300, elp3, kat5 kat14), may at least partly drive linuron-induced effects. results this genome-wide profiling contribute better understanding inheritance amphibians.
Language: Английский
Citations
8
Expert Review of Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: 19(4), P. 307 - 315
Published: May 18, 2024
The environmental spread of pollutants has led to a persistent exposure living beings multiple chemicals, by now become ubiquitous in the surrounding environment. Environmental these substances been reported cause multi- and/or transgenerational health effects. Per- and Polyfluorinated Substances (PFAS) raise great concern, given their known effects both as endocrine disruptors potential carcinogens. multi/trans-generational different have investigated several studies, harmful observed also for PFAS.
Language: Английский
Citations
8
Current Zoology, Journal Year: 2024, Volume and Issue: 10(1)
Published: Jan. 1, 2024
Abstract Environmentally induced epigenetic transgenerational inheritance of phenotypic variation and disease susceptibility requires the germ cell (sperm or egg) transmission integrated mechanisms involving DNA methylation, histone modifications, non-coding RNA (ncRNA) actions. Previous studies have demonstrated that exposure disease-specific differential methylation regions (DMRs) in sperm are observed ncRNA-mediated occurs. The current study was designed to determine if exposure-specific ncRNAs exist sperm. Specifically, toxicants with distinct action including fungicide vinclozolin (anti-androgenic), pesticide dichlorodiphenyltrichloroethane (estrogenic), herbicide atrazine (endocrine disruptor at cyclic adenosine monophosphate level), hydrocarbon mixture jet fuel (JP8) (aryl receptor disruptor) were used promote phenotypes F3 generation outbred rats. New aliquots sperm, previously collected for analyses, ncRNA sequencing analyses nuclear RNA. Significant changes each lineage. majority small noncoding RNAs piwi-interacting RNA, tRNA-derived RNAs, microRNAs, rRNA-derived as well long ncRNAs. Although there some overlap among different classes across exposures, differentially expressed no overlapping between four lineages chromosomal locations gene associations identified a number ncRNA. Interestingly, an analysis DMRs populations ncRNA, but large population non-overlapping Observations suggest both within common exposures. lack co-localization many suggests distal integration mechanisms. potential use toxicant assessment appears feasible.
Language: Английский
Citations
8
Journal of Ovarian Research, Journal Year: 2024, Volume and Issue: 17(1)
Published: Jan. 16, 2024
Abstract Background Bisphenol A (BPA), an endocrine disrupting chemical with weak estrogenic and anti-androgenic activity, is widely present in various environmental media organisms. It has certain reproductive toxicity can cause a variety of female system diseases. Although BPA-stimulated apoptosis granulosa cells been elaborated, the effect BPA on mouse pre-antral follicle (mpGCs) not well elucidated. Results In this study, results live-dead cell staining showed that high concentrations severely impaired mpGCs growth viability affected cycle transition mpGCs. We confirmed promotes production reactive oxygen species (ROS) facilitates oxidative stress addition, immunofluorescence, transmission electron microscopy, flow cytometry experiments demonstrated treatment for resulted apoptotic features, such as rounding, cytoplasmic crinkling, mitochondrial damage. This was accompanied by large ROS apoptosis-inducing factor (AIF) translocation from mitochondria to nucleus. RNA-seq data several apoptosis-related pathways were enriched concentration BPA-treated group compared normal group, p53 pathway, MAPK etc. Conclusions These suggest undergo effects after mpGCs, which affects development. The potential mechanism BPA-induced elucidated, while providing research basis prevention
Language: Английский
Citations
6
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 3, 2025
Seminal oxidative stress has been shown to be a key factor in the development of male infertility. However, benefits infertility treatments with antioxidants such as coenzyme Q10 (CoQ10) remains controversial. The aim present study was assess effects CoQ10 supplementation on semen quality, i.e., volume, total sperm number, concentration, motility, percentage progressive motility and morphology. In addition, circulating testosterone, luteinizing hormone (LH), follicle-stimulating (FSH), inhibin B levels were evaluated. A systematic review meta-analysis randomized controlled trials (RCTs) performed quality serum reproductive hormones. We conducted strategic literature search Cochrane, EMBASE, PubMed/MEDLINE, Scopus, Web Science databases collected only RCTs. data RCTs then meta-analyzed according PRISMA guidelines. Out 2,144 studies, eight classified eligible. studies included 877 subjects; 462 CoQ10-treated 415 untreated/placebo-treated. found significantly higher counts (SMD -13.38 [95% CI: -16.33, -10.43] P< 0.0001), -7.26 -10.15, -4.36] 0.00001) -6.386 -10.04, -2.73] P= 0.0006), normally formed -1.96 -3.29, -0.62] 0.004) subjects compared untreated/placebo-treated subjects. Nonetheless, there significant inter-study heterogeneity these studies. Moreover, testosterone -0.59 -0.79, -0.40] -0.92 -1.47, -0.37] 0.001) recorded lowered LH 1.77 1.26, 2.28] FSH concentrations 1.60 1.38, 1.81] 0.00001). Interestingly, no hormonal had effect volume 0.12 -0.13, 0.37] 0.34) concentration -6.69 -16.28, 2.90] 0.17). Our shows that increases count, proportion association levels. therefore supports view beneficial use treatment. further well-designed sufficiently large numbers are required reach final conclusion.
Language: Английский
Citations
0
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 298, P. 118269 - 118269
Published: May 10, 2025
Language: Английский
Citations
0
Environmental Pollution, Journal Year: 2024, Volume and Issue: 344, P. 123437 - 123437
Published: Jan. 23, 2024
Metolachlor (MET) is a widely used herbicide that can adversely affect phytoplanktonic non-target organisms, such as cyanobacteria. Chytrids are zoosporic fungi ubiquitous in aquatic environments parasitize cyanobacteria and keep their proliferation check. However, the influence of organic pollutants on interaction between species, including parasitism, associated ecological processes remain poorly understood. Using host-parasite system consisting toxigenic cyanobacterium Planktothrix agardhii its chytrid parasite Rhizophydium megarrhizum, we investigated effects environmentally relevant concentrations MET interactions under i) continuous exposure chytrids cyanobacteria, ii) pre-exposure chytrids. During exposure, infection prevalence intensity were not affected, but reproductive structures smaller at highest tested concentration. In parasite's absence, promoted growth possibly due to hormesis effect. assay, caused multi- transgenerational detrimental fitness. pre-exposed showed reduced infectivity, intensity, infection, sporangia size was reduced. Thus, resulted delayed decline cyanobacterial cultures upon infection. After several generations without recovered initial fitness, indicating transient. This study demonstrates herbicides, MET, could favor bloom formation both directly, by promoting growth, indirectly, inhibiting parasites, which known play key role top-down regulators addition, evidence relevance addressing multi-organism systems, interactions, toxicity assays. approach offers more comprehensive understanding ecosystems.
Language: Английский
Citations
3
European journal of ecology, biology and agriculture., Journal Year: 2024, Volume and Issue: 1(3), P. 152 - 184
Published: July 1, 2024
This review discusses the significant health risks posed by exposure to environmentally toxic heavy metals such as lead, mercury, cadmium, arsenic, chromium, and nickel. These can cause severe sometimes irreversible damage various organs systems in human body. Each metal has specific impacts, including neurological disorders, renal cardiovascular diseases, developmental delays, cancers. The paper highlights ability of these cross placental barrier, affecting fetal development resulting adverse pregnancy outcomes like preterm birth, low birth weight, issues. Heavy disrupt function inducing oxidative stress, mitochondrial dysfunction, impaired nutrient oxygen transport, leading long-term consequences for offspring. also explores how epigenetic changes, altering gene expression contributing chronic diseases. Some effects be transmitted across generations. contamination pharmaceuticals natural remedies with is a concern, emphasizing need rigorous quality control regulatory oversight protect public health. Diagnostic procedures detecting involve comprehensive history-taking, physical examinations, laboratory tests, neuroimaging, assessments motor functions. underscores importance addressing environmental mitigate their harmful impacts safeguard
Language: Английский
Citations
3