Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review DOI

Shaun R. Wesley,

Martina Gallo,

Tejumola Apata

et al.

Seminars in Reproductive Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Environmental pollutants, including endocrine-disrupting chemicals (EDCs), air pollution, and climate change, are increasingly recognized for their potential impact on pregnancy outcomes. EDCs, found in pesticides, industrial chemicals, personal care products, associated with preterm birth fetal growth restriction, primarily through hormonal interference. Air notably PM2.5, NO2, O3, has been linked to increased rates of birth, low weight, stillbirth. Climate factors, such as extreme heat, elevate risks loss significant impacts vulnerable populations across diverse socioeconomic geographic regions. These exposures contribute adverse outcomes mechanisms involving oxidative stress, inflammation, endocrine disruption. The interplay among these environmental factors underscores the need integrated, longitudinal studies understand combined effects better. Future research should focus region-specific impacts, cumulative exposure, policy-driven interventions mitigate risks, especially disproportionately affected by hazards. This scoping review synthesizes recent findings from 2019 2024 highlight associations identify gaps.

Language: Английский

Maternal–Foetal Effects of Exposure to Bisphenol A: Outcomes and Long-Term Consequences DOI Creative Commons
Henrique Eloi Costa,

Inês Medeiros,

Melissa Mariana

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 697 - 697

Published: Jan. 12, 2025

Exposure to bisphenol A (BPA), one of the most widely produced plasticisers, can have a major effect on growing embryo and mother during pregnancy; as this is vulnerable period, cutoff established in legislation does not take factor into account. Thus, narrative review aims highlight consequences for foetus pregnant woman maternal foetal exposure BPA by analysing epidemiological experimental studies humans. Extensive research has examined effects several systems outcomes. Specifically, affects immune system offspring promotes development respiratory diseases, including asthma wheezing. Moreover, been negatively associated with children’s neurodevelopment, leading behavioural changes; autism; reproductive changes, mainly deviations anogenital distance, sexual hormone levels maturation, which result infertility. Furthermore, mothers, may be linked pre-eclampsia gestational diabetes mellitus birth parameters, higher risk preterm delivery, shorter lengths lower weights, although results were always consistent. These demonstrate urgent need stricter banning use pregnancy reduce hazards health unborn child.

Language: Английский

Citations

0
The Effect of Bisphenol and Its Cytotoxicity on Female Infertility and Pregnancy Outcomes: A Narrative Review DOI Open Access

Εirini Drakaki,

Sofoklis Stavros,

Dimitra Dedousi

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7568 - 7568

Published: Dec. 12, 2024

Bisphenols, particularly bisphenol A (BPA), are among the most thoroughly investigated endocrine disrupting chemicals (EDCs). BPA was first synthetic estrogen to be identified, exerting its estrogenic effects through interaction with human receptors (ERs). The aim of present narrative review is summarize recent literature regarding adverse bisphenols on female fertility and pregnancy outcomes. in PubMed/Medline Scopus databases conducted November 2024 15 studies were included review. levels higher women diminished ovarian reserve, polycystic ovary syndrome, recurrent miscarriages. Furthermore, one study showed a significant association between onset gestational diabetes mellitus. Higher associated disruptions reproductive system, such as function, reduced number antral follicles, lower anti-Müllerian hormone (AMH) levels. Bisphenols S an increased risk developing F correlated birth weight seemed preterm delivery. Ultimately, further research necessary fully understand extent harmful that have separately mixtures system.

Language: Английский

Citations

2
Gestational Exposure to Endocrine-Disrupting Chemicals of Emerging Concern and the Risk of Developing Gestational Diabetes Mellitus: A Comprehensive Investigation of Sex-Specific and Trimester-Specific Associations DOI Creative Commons

Jinfeng Fu,

Yao Yao, Zhihong Huang

et al.

Environment & Health, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Gestational diabetes mellitus (GDM) is a type of that arises during pregnancy, leading to long-term adverse consequences for maternal health and fetal development. However, the specific role endocrine-disrupting chemicals (EDCs) in pathogenesis GDM remains controversial. This prospective cohort study sought investigate how coexposure bisphenols, parabens, triclosan (TCS), benzophenone-type UV filters, neonicotinoids (NEOs) affects odds GDM. Quantile-based g-computation Bayesian kernel machine regression showed significant inverse relationship between EDC mixtures reduced risk (OR = 0.34, 95% CI: 0.13-0.87), which was mainly explained by bisphenol 0.49, 0.29-0.80) paraben 0.60, 0.40-0.91) exposure. Bisphenol S (BPS), Z (BPZ), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP) were identified as key contributors joint effect. In addition, subgroup analyses suggested bisphenols-GDM association more pronounced younger/normal-weight participants. The sex-specific impact exposure bisphenols on development observed, whereas second trimester represented critical window Continued research efforts, focusing causal pathways nonmonotonic relationships, will be crucial elucidate complex influence

Language: Английский

Citations

1
Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review DOI

Shaun R. Wesley,

Martina Gallo,

Tejumola Apata

et al.

Seminars in Reproductive Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Abstract Environmental pollutants, including endocrine-disrupting chemicals (EDCs), air pollution, and climate change, are increasingly recognized for their potential impact on pregnancy outcomes. EDCs, found in pesticides, industrial chemicals, personal care products, associated with preterm birth fetal growth restriction, primarily through hormonal interference. Air notably PM2.5, NO2, O3, has been linked to increased rates of birth, low weight, stillbirth. Climate factors, such as extreme heat, elevate risks loss significant impacts vulnerable populations across diverse socioeconomic geographic regions. These exposures contribute adverse outcomes mechanisms involving oxidative stress, inflammation, endocrine disruption. The interplay among these environmental factors underscores the need integrated, longitudinal studies understand combined effects better. Future research should focus region-specific impacts, cumulative exposure, policy-driven interventions mitigate risks, especially disproportionately affected by hazards. This scoping review synthesizes recent findings from 2019 2024 highlight associations identify gaps.

Language: Английский

Citations

0