Systematic review of exosome treatment in hair restoration: Preliminary evidence, safety, and future directions

Journal of Cosmetic Dermatology, Journal Year: 2023, Volume and Issue: 22(9), P. 2424 - 2433

Published: June 28, 2023

Abstract Background Exosomes are small extracellular vesicles with potential roles in modulating the hair growth cycle and an emerging therapy for patients alopecia. In recent years, researchers have made significant progress deciphering network of cellular interactions signaling pathways mediated by transfer exosomes. This has opened door to a wide range therapeutic applications increasing focus on its application precision medicine. Aim To evaluate current published evidence, both preclinical clinical, use exosomes restoration. Methods January 2023, systematic search was conducted using PubMed, Embase, Cochrane Library. Records were identified, screened, assessed eligibility as per PRISMA guideline. Results We identified 16 studies (15 1 clinical) showing varying degrees efficacy derived from sources including adipose‐derived stem cells (ADSCs) dermal papilla (DPCs). Applications isolated ADSCs (ADSC‐Exo) DPCs shown early promising results corroborated obtained different model systems. Topical ADSC‐Exo been tried successfully 39 androgenetic alopecia demonstrating increases density thickness. No adverse reactions associated exosome treatment reported thus far. Conclusions Although clinical evidence supporting is limited, there growing body suggesting potential. Further warranted define mechanism action, optimize delivery efficacy, address important safety concerns.

Language: Английский

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Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?

Current Oncology, Journal Year: 2023, Volume and Issue: 30(4), P. 3609 - 3626

Published: March 25, 2023

Millions of new cancer patients receive chemotherapy each year. In addition to killing cells, is likely damage rapidly proliferating healthy including the hair follicle keratinocytes. Chemotherapy causes substantial thinning or loss hair, termed chemotherapy-induced alopecia (CIA), in approximately 65% patients. CIA often ranked as one most distressing adverse effects chemotherapy, but interventional options have been limited. To date, only scalp cooling has cleared by US Food and Drug Administration (FDA) prevent CIA. However, several factors, high costs not always covered insurance, preclude its broader use. Here we review current for prevention treatment discuss approaches being tested. interventions include systems (both non-portable portable) topical agents loss, versus oral minoxidil, photobiomodulation therapy (PBMT), platelet-rich plasma (PRP) injections, among others, stimulate regrowth after loss. Evidence-based studies are needed develop validate methods and/or accelerate receiving which could significantly improve patients’ quality life may help compliance consequently outcome treatment.

Language: Английский

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Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases

Cosmetics, Journal Year: 2023, Volume and Issue: 10(2), P. 65 - 65

Published: April 20, 2023

Exosomes are small extracellular nanovesicles that released by cells, and their potential has been explored for use in cosmetics, skin care, tissue regeneration, dermatological diseases. The therapeutic value of exosomes lies ability to modulate the microenvironment regulate gene expression, induce cell differentiation, which can have a positive impact on health. In terms used reduce wrinkles, improve texture hydration, enhance elasticity, as well inflammation damage caused UV radiation. Furthermore, promote regeneration wounds treat diseases such systemic lupus erythematosus, psoriasis, atopic dermatitis, sclerosis, pigment regulation, vitiligo, hair growth. this review, field diseases, elaborated. existing literature demonstrated with further research, may become viable option many conditions.

Language: Английский

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Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2288 - 2288

Published: May 13, 2024

This narrative review aims to examine the therapeutic potential and mechanism of action plant extracts in preventing treating alopecia (baldness). We searched selected research papers on related hair loss, growth, or regrowth, comprehensively compared efficacies, phytochemical components, modulatory targets extracts. These studies showed that various increased survival proliferation dermal papilla cells vitro, enhanced cell growth follicles ex vivo, promoted regrowth animal models vivo. The growth-promoting efficacy several was verified clinical trials. Some phenolic compounds, terpenes terpenoids, sulfur-containing fatty acids were identified as active compounds contained pharmacological effects their associated with promotion survival, proliferation, cycle progression, upregulation factors, such IGF-1, VEGF, HGF, KGF (FGF-7), leading induction extension anagen phase cycle. Those also alleviation oxidative stress, inflammatory response, cellular senescence, apoptosis, downregulation male hormones receptors, entry into telogen Several phytochemicals stimulated signaling pathways mediated by protein kinase B (PKB, called AKT), extracellular signal-regulated kinases (ERK), Wingless Int-1 (WNT), sonic hedgehog (SHH), while suppressing other transforming factor (TGF)-β bone morphogenetic (BMP). Thus, well-selected can have beneficial health. It is proposed discovery targeting aforementioned events will facilitate development new targeted therapies for alopecia.

Language: Английский

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Status of research on the development and regeneration of hair follicles

International Journal of Medical Sciences, Journal Year: 2023, Volume and Issue: 21(1), P. 80 - 94

Published: Nov. 15, 2023

Hair loss, or alopecia, is a prevalent condition in modern society that imposes substantial mental and psychological burden on individuals. The types of hair include androgenetic alopecia areata, telogen effluvium; them, the most common condition. Traditional treatment modalities mainly involve medical options, such as minoxidil, finasteride surgical interventions, transplantation. However, these treatments still have many limitations. Therefore, exploring pathogenesis specifically focusing development regeneration follicles (HFs), developing new strategies for promoting regrowth are essential. Some emerging therapies loss gained prominence; low-level laser therapy, micro needling, fractional radio frequency, platelet-rich plasma, stem cell therapy. aforementioned therapeutic appear promising management. In this review, we investigated mechanisms underlying HF regeneration. For this, studied structure, development, cycle, cellular function HFs. addition, analyzed symptoms, types, causes well its current conventional treatments. Our study provides an overview effective regenerative medicine-based loss.

Language: Английский

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Clinical and preclinical approach in AGA treatment: a review of current and new therapies in the regenerative field

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 15, 2024

Abstract Androgenetic alopecia (AGA) is the most prevalent type of hair loss. Its morbility mainly psychological although an increased incidence in melanoma has also been observed affected subjects. Current drug based therapies and physical treatments are either unsuccessful long term or have relevant side effects that limit their application. Therefore, a new therapeutic approach needed to promote regenerative enhancement alternatives. These treatment options, focused on cellular niche restoration, could be solution impact dihydrotestosterone follicle microenvironment. In this context emerging such as Platelet-rich plasma fibrine well stem cells mesenchymal cell derivatives (conditioned medium CM exoxomes) highlighting evolving landscape restoration. Nanotechnology leading way AGA through design bioinks nanobiomaterials whose structures being configuring huge range cases by means 3D bioprinting. Due increasing number rapid creation advanced alternatives field, extended review current state art needed. addition provides general insight which intented guidance for researchers cutting edge recently gaining ground.

Language: Английский

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Hydrogel-mediated delivery of platelet-derived exosomes: Innovations in tissue engineering

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24584 - e24584

Published: Jan. 1, 2024

In this scholarly review, we conduct a thorough examination of the significant role played by platelet-derived exosomes (Plt-Exos) and hydrogels in fields tissue engineering regenerative medicine. Our detailed investigation highlights central involvement Plt-Exos various physiological pathological processes, underscoring their potential contributions to diverse areas such as wound healing, neural rejuvenation, cancer progression. Despite promising therapeutic aspects, notable variability isolation characterization pEVs underscores need for more rigorous standardized methodology. Shifting our focus hydrogels, they have emerged biomaterials relevant Their unique characteristics, especially chemical physical adaptability, along with modifiability biochemical properties, make captivating subject. These exceptional features open avenues numerous applications, facilitating delivery essential growth factors, cytokines, microRNAs. This analysis explores innovative integration presenting novel paradigm engineering. Through incorporation into there exists an opportunity enhance regeneration endeavors combining bioactive restorative capabilities hydrogel frameworks. conclusion, cooperative interaction between indicates path Nevertheless, successful execution approach requires deep understanding molecular dynamics, coupled dedication refining techniques.

Language: Английский

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Platelet-Rich Plasma in Dermatology: New Insights on the Cellular Mechanism of Skin Repair and Regeneration

Life, Journal Year: 2023, Volume and Issue: 14(1), P. 40 - 40

Published: Dec. 25, 2023

The skin's recognised functions may undergo physiological alterations due to ageing, manifesting as varying degrees of facial wrinkles, diminished tautness, density, and volume. Additionally, these can be disrupted (patho)physiologically through various physical chemical injuries, including surgical trauma, accidents, or chronic conditions like ulcers associated with diabetes mellitus, venous insufficiency, obesity. Advancements in therapeutic interventions that boost the innate regenerative abilities could significantly enhance patient care protocols. application Platelet-Rich Plasma (PRP) is widely recognized for its aesthetic functional benefits skin. Yet, endorsement PRP's advantages often borders on dogmatic, efficacy commonly ascribed solely activation fibroblasts by factors contained within platelet granules. PRP therapy a cornerstone medicine which involves autologous delivery conditioned plasma enriched platelets. This achieved centrifugation, removing erythrocytes while retaining platelets their Despite widespread use, precise sequences cellular activation, specific players, molecular machinery drive PRP-facilitated healing are still enigmatic. There paucity definitive robust studies elucidating mechanisms. In recent years, telocytes (TCs)-a unique dermal cell population-have shown promising potential tissue regeneration organs, dermis. TCs' participation neo-angiogenesis, akin attributed PRP, role remodelling repair processes interstitia several organs (including dermis), offer intriguing insights. Their contribute to, possibly orchestrate, skin process following treatment has elicited considerable interest. Therefore, pursuing comprehensive understanding mechanisms at work, particularly those involving TCs, temporal involvement structural recovery injury, interconnected biological events wound represents compelling field study.

Language: Английский

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Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(2), P. 89 - 101

Published: Feb. 25, 2024

This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular periocular enhancement, demands advanced solutions tissue restoration, functional aesthetic refinement, aging. Investigating immunomodulatory, regenerative, healing capacities MSCs, this underscores use MSCs as cost-effective alternative from bench to bedside, addressing common unmet needs in field reconstructive regenerative surgery.

Language: Английский

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Enhancing Quality of Life and Sexual Functioning in Female Androgenetic Alopecia: Therapeutic Potential of Hair Follicle-Derived Stem Cells

Healthcare, Journal Year: 2024, Volume and Issue: 12(6), P. 608 - 608

Published: March 7, 2024

Background: The study aimed to examine the impact of stem cell treatment on quality life (QoL) and sexual functioning in women with androgenetic alopecia (AGA). Methods: Twenty-three underwent a single session autologous cellular micrografts (ACMs). World Health Organization Quality Life Brief Version (WHOQOL-BREF) Female Sexual Function Index (FSFI) were used before after 6 months. Results: AGA severity decreased by an average 1 point Ludwig scale (p = 0.004) treatment. FSFI scores indicated dysfunction over half at baseline, but they improved significantly post-treatment for arousal [median (IQR): 4.8 (1.5) vs. 5.10 (0.9); p 0.035] satisfaction [4.4 (1.4) (1.8); 0.025]. QoL psychological health (57.96 ± 19.0 69.35 14.0; 0.031) environment (72.96 13.4 81.09 12.6; 0.007), not physical social relationships. No associations found between WHOQOL-BREF or domains versus age severity. Conclusions: reduces impacts AGA. high burden arises from chronic progressive nature AGA, coupled limited effectiveness. Effective treatments like ACM, are urgently needed enhance patient-reported outcomes along clinical results.

Language: Английский

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