Starch - Stärke,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
ABSTRACT
The
biocompatible
and
biodegradable
polysaccharide
starch
is
a
great
platform
for
the
development
of
nanoparticles
(NPs).
Due
to
its
special
qualities,
which
include
high
stability,
low
toxicity,
ease
modification,
it
desirable
option
administration
anticancer
drugs.
Targeted
cancer
therapy
has
found
potential
carrier
in
starch‐based
(SNPs).
SNPs
can
be
functionalized
with
ligands
target
cells
particular.
These
allow
targeted
medication
delivery
by
identifying
overexpressed
receptors
on
tumor
surfaces.
have
been
studied
relation
chemotherapeutics,
siRNAs,
photothermal
treatments,
among
other
agents.
They
are
also
used
combination
therapy,
where
their
combined
targeting
improves
treatment
outcomes.
being
evaluated
number
clinical
trials.
trials
evaluate
patient
outcomes,
safety,
efficacy
offer
important
information
future
uses.
Regulatory
bodies
closely
monitor
various
treatments
based
NPs.
Clinical
translation
requires
an
understanding
safety
profiles,
biodistribution,
clearance
mechanisms.
In
this
review,
we
examine
enhance
through
drug
targeting.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(13), P. 8297 - 8346
Published: June 15, 2023
Omics
technologies
have
rapidly
evolved
with
the
unprecedented
potential
to
shape
precision
medicine.
Novel
omics
approaches
are
imperative
toallow
rapid
and
accurate
data
collection
integration
clinical
information
enable
a
new
era
of
healthcare.
In
this
comprehensive
review,
we
highlight
utility
Raman
spectroscopy
(RS)
as
an
emerging
technology
for
clinically
relevant
applications
using
significant
samples
models.
We
discuss
use
RS
both
label-free
approach
probing
intrinsic
metabolites
biological
materials,
labeled
where
signal
from
reporters
conjugated
nanoparticles
(NPs)
serve
indirect
measure
tracking
protein
biomarkers
Luminescence,
Journal Year:
2025,
Volume and Issue:
40(2)
Published: Jan. 31, 2025
ABSTRACT
A
novel
fluorescence‐based
sensor
has
been
developed
for
the
sensitive
detection
of
malathion,
an
organophosphorus
pesticide,
using
sulfur‐doped
quantum
dots
(SQDs)
embedded
within
graphitic
carbon
nitride
(g‐C₃N₄)
nanosheets.
The
SQDs
were
synthesized
through
a
hydrothermal
method,
whereas
g‐C₃N₄
nanosheets
produced
via
exfoliation
process.
resulting
SQDs@g‐C₃N₄
nanocomposite
demonstrated
outstanding
performance
malathion
in
food
samples,
exhibiting
wide
linear
range
10–120
μM
and
exceptionally
low
limit
0.02
μM.
This
sensitivity
allows
accurate
rapid
pesticide
monitoring
at
trace
levels.
sensor's
was
optimized
by
varying
experimental
conditions,
ensuring
that
it
provided
high
sensitivity,
excellent
stability,
impressive
selectivity
toward
even
complex
matrices.
Molecular Biotechnology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
One
kind
of
hydroxycinnamic
acid
is
calceolarioside
A.
Plantago
coronopus,
Cassinopsis
madagascariensis,
and
other
organisms
for
whom
data
are
available
known
to
have
this
naturally
occurring
compound.
IC50
values
Calceolarioside
A
ovarian
cell
lines
(NIH-OVCAR-3,
ES-2,
UACC-1598,
Hs832.Tc,
TOV-21G,
UWB1.289)
were
24.42,
13.50,
9.31,
14.90,
20.07,
16.18
µM,
respectively.
19.83
73.48
µM
tyrosinase
HMG-CoA
reductase
enzymes.
The
chemical
activities
against
assessed
by
conducting
the
molecular
docking
study,
MM/GBSA
calculation,
dynamics
(MD)
simulation.
anticancer
compound
evaluated
some
cancer
cells,
such
as
NIH-OVCAR-3,
UWB1.289
lines.
expressed
surface
receptor
proteins
(folate
receptor,
CD44,
EGFR,
Formyl
Peptide
Receptor-Like
1,
M2
muscarinic
estrogen
receptors)
investigated
using
computational
methods.
results
exhibited
interplay
among
atoms.
formed
robust
associations
with
both
enzymes
receptors.
can
hinder
functioning
these
proliferation
malignant
cells.
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 29, 2025
Breast
cancer
remains
the
most
frequently
diagnosed
globally,
exerting
a
profound
impact
on
women's
health
and
healthcare
systems.
Central
to
its
pathogenesis
therapeutic
resistance
are
breast
stem
cells
(BCSCs),
which
possess
unique
properties
such
as
self-renewal,
differentiation,
conventional
therapies,
contributing
tumor
initiation,
metastasis,
recurrence.
This
comprehensive
review
elucidates
pivotal
role
of
mechanistic
target
rapamycin
(mTOR)
pathway
in
regulating
BCSCs
implications
for
progression
treatment
resistance.
We
explore
cellular
mechanisms
by
mTOR
influences
metabolism,
autophagy,
ferroptosis
BCSCs,
highlighting
contribution
epithelial-to-mesenchymal
transition
(EMT),
metabolic
reprogramming,
survival
under
stress.
On
molecular
level,
interacts
with
key
signaling
pathways
including
PI3K/Akt,
Notch,
IGF-1R,
AMPK,
TGF-β,
well
regulatory
proteins
non-coding
RNAs,
orchestrating
complex
network
that
sustains
BCSC
mediates
chemoresistance
radioresistance.
The
further
examines
various
strategies
targeting
encompassing
selective
PI3K/Akt/mTOR
inhibitors,
monoclonal
antibodies,
natural
products,
innovative
approaches
nanoparticle-mediated
drug
delivery.
Clinical
trials
investigating
inhibitors
like
sirolimus
combination
therapies
agents
everolimus
trastuzumab
discussed,
underscoring
their
potential
eradicating
improving
patient
outcomes.
Additionally,
compounds
repurposed
drugs
offer
promising
adjunctive
modulating
activity
BCSC-specific
vulnerabilities.
In
conclusion,
presents
viable
avenue
enhancing
efficacy
effectively
eliminating
reducing
recurrence,
overall
survival.
Continued
research
clinical
validation
mTOR-targeted
essential
translate
these
insights
into
effective
interventions,
ultimately
advancing
personalized
management
outcomes
patients.
