Water Research, Journal Year: 2022, Volume and Issue: 222, P. 118878 - 118878

Published: July 18, 2022

This study aimed to provide insights into the risk posed by psychopharmaceuticals and illicit drugs in European surface waters, identify current knowledge gaps hampering this assessment. First, availability quality of data on concentrations waters (occurrence) toxicity aquatic organisms (hazard) were reviewed. If both occurrence ecotoxicity available, quotients (risk) calculated. Where abundant a species sensitivity distribution (SSD) was constructed, from which hazardous concentration for 5% (HC5) derived, allowing derive integrated multi-species risks. A total 702 compounds categorised as based combination all 502 anatomical therapeutic class (ATC) 'N' pharmaceuticals list according Dutch Opium Act. Of these, 343 (49%) returned data, while only 105 (15%) data. Moreover, many tests used irrelevant endpoints neurologically active compounds, such mortality, may underestimate hazard psychopharmaceuticals. Due limitations, risks could be assessed 87 (12%) with 23 (3.3%) indicating potential risk, several highly prescribed neither nor Primary bottlenecks calculation included lack diversity test ecotoxicological end points, large disparities between well studied understudied identified merit concern, that any driving research priorities. Despite gaps, we concluded presence substantial part (26%) data-rich present an ecological non-target organisms.

Language: Английский