High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage DOI Creative Commons
Yunjia Lai, Jeremy P. Koelmel, Douglas G. Walker

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(29), P. 12784 - 12822

Published: July 10, 2024

In the modern "omics" era, measurement of human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics metabolomics, has emerged as leading technology to broadly profile chemical exposure agents related biomolecules for accurate measurement, high sensitivity, rapid data acquisition, increased resolution space. Non-targeted approaches are increasingly accessible, supporting shift from conventional hypothesis-driven, quantitation-centric targeted analyses toward data-driven, hypothesis-generating exposome-wide profiling. However, HRMS-based exposomics encounters unique challenges. New analytical computational infrastructures needed expand analysis coverage through streamlined, scalable, harmonized workflows pipelines that permit longitudinal tracking, retrospective validation, multi-omics integration meaningful health-oriented inferences. this article, we survey literature on state-of-the-art technologies, review current informatic pipelines, provide an up-to-date reference exposomic chemists, toxicologists, epidemiologists, care providers, stakeholders health sciences medicine. We propose efforts benchmark fit-for-purpose platforms expanding space, including gas/liquid chromatography-HRMS (GC-HRMS LC-HRMS), discuss opportunities, challenges, strategies advance burgeoning field exposome.

Language: Английский

A review on environmental monitoring of water organic pollutants identified by EU guidelines DOI

João C.G. Sousa,

Ana R. Ribeiro, Marta O. Barbosa

et al.

Journal of Hazardous Materials, Journal Year: 2017, Volume and Issue: 344, P. 146 - 162

Published: Oct. 4, 2017

Language: Английский

Citations

747

Tracking complex mixtures of chemicals in our changing environment DOI
Beate I. Escher, Heather M. Stapleton, Emma Schymanski

et al.

Science, Journal Year: 2020, Volume and Issue: 367(6476), P. 388 - 392

Published: Jan. 24, 2020

Chemicals have improved our quality of life, but the resulting environmental pollution has potential to cause detrimental effects on humans and environment. People biota are chronically exposed thousands chemicals from various sources through multiple pathways. Environmental chemists toxicologists moved beyond detecting quantifying single characterizing complex mixtures in indoor outdoor environments biological matrices. We highlight analytical bioanalytical approaches isolating, characterizing, tracking groups concern Techniques that combine chemical analysis bioassays facilitate identification pose a combined risk.

Language: Английский

Citations

577

Water Analysis: Emerging Contaminants and Current Issues DOI
Susan D. Richardson, Thomas A. Ternes

Analytical Chemistry, Journal Year: 2017, Volume and Issue: 90(1), P. 398 - 428

Published: Nov. 7, 2017

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTWater Analysis: Emerging Contaminants and Current IssuesSusan D. Richardson*† Thomas A. Ternes‡View Author Information† Department of Chemistry Biochemistry, University South Carolina, Columbia, Carolina 29205, United States‡ Federal Institute Hydrology, Koblenz, D-56068, Germany*E-mail: [email protected]Cite this: Anal. Chem. 2018, 90, 1, 398–428Publication Date (Web):November 7, 2017Publication History Published online30 November 2017Published inissue 2 January 2018https://doi.org/10.1021/acs.analchem.7b04577Copyright © 2017 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views10421Altmetric-Citations381LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit Read OnlinePDF (584 KB) Get e-AlertsSUBJECTS:Anions,Drinking water,Impurities,Pharmaceuticals,Water treatment e-Alerts

Language: Английский

Citations

553

Which Micropollutants in Water Environments Deserve More Attention Globally? DOI
Yun Yang, Xiangru Zhang, Jingyi Jiang

et al.

Environmental Science & Technology, Journal Year: 2021, Volume and Issue: 56(1), P. 13 - 29

Published: Dec. 21, 2021

Increasing chemical pollution of aquatic environments is a growing concern with global relevance. A large number organic chemicals are termed as "micropollutants" due to their low concentrations, and long-term exposure micropollutants may pose considerable risks organisms human health. In recent decades, numerous treatment methods technologies have been proposed remove in water, typically several were chosen target pollutants evaluate removal efficiencies. However, it often unclear whether toxicity occurrence levels frequencies enable them contribute significantly the overall environments. This review intends answer an important lingering question: Which or class deserve more attention globally should be removed higher priority? Different risk-based prioritization approaches used address this question. The risk quotient (RQ) method was found feasible approach prioritize scale its relatively simple assessment procedure extensive use. total 83 case studies using RQ past decade compiled, 473 compounds that selected by screening 3466 three broad classes (pharmaceuticals personal care products (PPCPs), pesticides, industrial chemicals) (RQ > 0.01). To determine importance, we propose surrogate, is, weighted average (WARQ). WARQ integrates intensity frequency achieve comprehensive priority determination. Through metadata analysis, recommend ranked list 53 micropollutants, including 36 PPCPs (e.g., sulfamethoxazole ibuprofen), seven pesticides heptachlor diazinon), 10 perfluorooctanesulfonic acid 4-nonylphenol) for management remediation efforts. One caveat importance does not consider transformation (including disinfection byproducts) new forms antibiotic resistance genes microplastics), directly applicable specific region country. Also, needs mentioning there might no best toward question, hopefully can act small step better answer.

Language: Английский

Citations

358

Towards the review of the European Union Water Framework Directive: Recommendations for more efficient assessment and management of chemical contamination in European surface water resources DOI
Werner Brack, Valeria Dulio, Marlene Ågerstrand

et al.

The Science of The Total Environment, Journal Year: 2016, Volume and Issue: 576, P. 720 - 737

Published: Oct. 28, 2016

Language: Английский

Citations

311

Detoxification of water and wastewater by advanced oxidation processes DOI
D. Syam Babu, Vartika Srivastava,

P.V. Nidheesh

et al.

The Science of The Total Environment, Journal Year: 2019, Volume and Issue: 696, P. 133961 - 133961

Published: Aug. 17, 2019

Language: Английский

Citations

301

Expanded Target-Chemical Analysis Reveals Extensive Mixed-Organic-Contaminant Exposure in U.S. Streams DOI Creative Commons
Paul M. Bradley, Celeste A. Journey, Kristin M. Romanok

et al.

Environmental Science & Technology, Journal Year: 2017, Volume and Issue: 51(9), P. 4792 - 4802

Published: April 12, 2017

Surface water from 38 streams nationwide was assessed using 14 target-organic methods (719 compounds). Designed-bioactive anthropogenic contaminants (biocides, pharmaceuticals) comprised 57% of 406 organics detected at least once. The 10 most-frequently anthropogenic-organics included eight pesticides (desulfinylfipronil, AMPA, chlorpyrifos, dieldrin, metolachlor, atrazine, CIAT, glyphosate) and two pharmaceuticals (caffeine, metformin) with detection frequencies ranging 66–84% all sites. Detected contaminant concentrations varied less than 1 ng L–1 to greater μg L–1, 77 278 having median 100 respectively. Cumulative detections ranged 4–161 compounds (median 70) 8.5–102 847 respectively, correlated significantly wastewater discharge, watershed development, toxic release inventory metrics. Log10 widely monitored HHCB, triclosan, carbamazepine explained 71–82% the variability in total number (linear regression; p-values: < 0.001–0.012), providing a statistical inference tool for unmonitored contaminants. Due multiple modes action, high bioactivity, biorecalcitrance, direct environment application (pesticides), designed-bioactive 41 per site cumulative concentrations) developed watersheds present aquatic health concerns, given their acknowledged potential sublethal effects sensitive species lifecycle stages low L–1.

Language: Английский

Citations

298

Multiple Roles of Dissolved Organic Matter in Advanced Oxidation Processes DOI
Xin Yang, Fernando L. Rosario‐Ortiz, Yu Lei

et al.

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(16), P. 11111 - 11131

Published: July 7, 2022

Advanced oxidation processes (AOPs) can degrade a wide range of trace organic contaminants (TrOCs) to improve the quality potable water or discharged wastewater effluents. Their effectiveness is impacted, however, by dissolved matter (DOM) that ubiquitous in all sources. During application an AOP, DOM scavenge radicals and/or block light penetration, therefore impacting their toward contaminant transformation. The multiple ways which different types sources impact oxidative purification are critically reviewed. inhibit degradation TrOCs, but it also enhance formation and reactivity useful for elimination alter transformation pathways contaminants. An in-depth analysis highlights inhibitory effect on efficiency TrOCs based DOM's structure optical properties its oxidants as well synergistic contribution from redox transient intermediates. AOPs influence types, mechanisms, extent byproducts formation. Research needs proposed advance practical understanding how be exploited purification.

Language: Английский

Citations

252

Emerging pollutants in the EU: 10 years of NORMAN in support of environmental policies and regulations DOI Creative Commons
Valeria Dulio, Bert van Bavel,

Eva Brorström‐Lundén

et al.

Environmental Sciences Europe, Journal Year: 2018, Volume and Issue: 30(1)

Published: Jan. 30, 2018

In 2005, the European Commission funded NORMAN project to promote a permanent network of reference laboratories and research centers, including academia, industry, standardization bodies, NGOs. Since then, has (i) facilitated more rapid wide-scope exchange data on occurrence effects contaminants emerging concern (CECs), (ii) improved quality comparability via validation harmonization common sampling measurement methods (chemical biological), (iii) provided transparent information monitoring CECs, (iv) established an independent competent forum for technical/scientific debate issues related substances. plays significant role as organization at interface between science policy, with advantage speaking other public institutions "bigger voice" than 70 members from 20 countries. This article provides summary first 10 years network. It takes stock work done so far outlines NORMAN's vision Europe-wide collaboration CECs sustainable links policy-making. contains overview state play in prioritizing substances several innovative technologies approaches. point view burning issue—the regulation CECs—and presents positions various stakeholders field (DG ENV, EEA, ECHA, national agencies) who participated workshop October 2016. The main messages conclusions round table discussions are briefly presented.

Language: Английский

Citations

242

Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive DOI
Beate I. Escher,

Selim Aїt‐Aїssa,

Peter Behnisch

et al.

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 628-629, P. 748 - 765

Published: Feb. 20, 2018

Language: Английский

Citations

217