Outside the Safe Operating Space of the Planetary Boundary for Novel Entities

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(3), P. 1510 - 1521

Published: Jan. 18, 2022

We submit that the safe operating space of planetary boundary novel entities is exceeded since annual production and releases are increasing at a pace outstrips global capacity for assessment monitoring. The in boundaries framework refers to geological sense could have large-scale impacts threaten integrity Earth system processes. review scientific literature relevant quantifying highlight plastic pollution as particular aspect high concern. An impact pathway from on processes presented. define apply three criteria suitability control variables boundary: feasibility, relevance, comprehensiveness. propose several complementary capture complexity this boundary, while acknowledging major data limitations. conclude humanity currently outside based weight-of-evidence these variables. rate larger volumes higher numbers with diverse risk potentials exceed societies' ability conduct safety related assessments recommend taking urgent action reduce harm associated exceeding by reducing entities, noting even so, persistence many and/or their effects will continue pose threat.

Language: Английский

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A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon

Science, Journal Year: 2020, Volume and Issue: 371(6525), P. 185 - 189

Published: Dec. 3, 2020

In U.S. Pacific Northwest coho salmon (

Language: Английский

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Sensors for Volatile Organic Compounds

ACS Nano, Journal Year: 2022, Volume and Issue: 16(5), P. 7080 - 7115

Published: May 5, 2022

This paper provides an overview of recent developments in the field volatile organic compound (VOC) sensors, which are finding uses healthcare, safety, environmental monitoring, food and agriculture, oil industry, other fields. It starts by briefly explaining basics VOC sensing reviewing currently available quickly progressing approaches. then discusses main trends materials' design with special attention to nanostructuring nanohybridization. Emerging materials strategies highlighted their involvement different types technologies is discussed, including optical, electrical, gravimetric sensors. The review also detailed discussions about limitations offers potential solutions. status suggestions promising directions for future development summarized.

Language: Английский

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Precision medicine in the era of artificial intelligence: implications in chronic disease management

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: Dec. 1, 2020

Abstract Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to and leading diminished life expectancy. A dysregulated induces secretion molecules which in turn trigger inflammatory pathway. Inflammation natural reaction immune system variety stimuli, such as pathogens, damaged cells, harmful substances. Metabolically triggered inflammation, also called metaflammation or low-grade chronic consequence synergic interaction between host exposome—a combination environmental drivers, including diet, lifestyle, pollutants other factors throughout span an individual. Various levels inflammation are associated with lifestyle-related diseases diabetes, obesity, metabolic fatty liver disease (MAFLD), cancers, cardiovascular disorders (CVDs), autoimmune diseases, lung diseases. Chronic growing concern worldwide, placing heavy on individuals, families, governments, health-care systems. New strategies needed empower communities worldwide prevent treat these Precision medicine provides model for next generation lifestyle modification. This will capitalize dynamic individual’s biology, behavior, environment. The aim precision design improve diagnosis, therapeutics prognostication through use large complex datasets that incorporate individual gene, function, variations. implementation high-performance computing (HPC) artificial intelligence (AI) can predict risks greater accuracy based available multidimensional clinical biological datasets. AI-powered clinicians opportunity specifically tailor early interventions each In this article, we discuss strengths limitations existing evolving recent, data-driven technologies, AI, preventing, treating reversing

Language: Английский

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Photocatalytic degradation of steroid hormone micropollutants by TiO2-coated polyethersulfone membranes in a continuous flow-through process

Nature Nanotechnology, Journal Year: 2022, Volume and Issue: 17(4), P. 417 - 423

Published: March 31, 2022

Language: Английский

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Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

Molecular Autism, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 10, 2020

The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds genes, converging at functional level on selective biological domains such as epigenetic regulation synaptic function, have been identified to be either causative or risk factors autism. other exposure chemicals that are widespread in environment, endocrine disruptors, has associated with adverse effects human health, including neurodevelopmental disorders. Interestingly, experimental results suggest an overlap regulatory pathways perturbed by mutations factors, depicting convergences interplays susceptibility toxic insults. pervasive nature chemical poses pivotal challenges for neurotoxicological studies, agencies, policy makers. This highlights emerging need developing new integrative models, biomonitoring, epidemiology, experimental, computational tools, able capture real-life scenarios encompassing interaction chronic mixture substances individuals' backgrounds. In this review, we address intertwined roles lesions Specifically, outline transformative potential stem cell coupled omics analytical approaches increasingly single resolution, tools experimentally dissect pathogenic mechanisms underlying disorders, well improve developmental neurotoxicology assessment.

Language: Английский

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Assessing the human health risks of per- and polyfluoroalkyl substances: A need for greater focus on their interactions as mixtures

Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 407, P. 124863 - 124863

Published: Dec. 17, 2020

Language: Английский

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Emerging contaminants: A One Health perspective

The Innovation, Journal Year: 2024, Volume and Issue: 5(4), P. 100612 - 100612

Published: March 13, 2024

Language: Английский

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Uncovering global-scale risks from commercial chemicals in air

Nature, Journal Year: 2021, Volume and Issue: 600(7889), P. 456 - 461

Published: Dec. 15, 2021

Language: Английский

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Metal–organic frameworks (MOFs) for the efficient removal of contaminants from water: Underlying mechanisms, recent advances, challenges, and future prospects

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 468, P. 214595 - 214595

Published: May 30, 2022

Language: Английский

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