Immunotoxicity and neurotoxicity of bisphenol A and microplastics alone or in combination to a bivalve species, Tegillarca granosa

Environmental Pollution, Journal Year: 2020, Volume and Issue: 265, P. 115115 - 115115

Published: June 27, 2020

Language: Английский

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Effect of bisphenol A on the neurological system: a review update

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 98(1), P. 1 - 73

Published: Oct. 19, 2023

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy resins polycarbonate plastics, which are frequently used food storage baby bottles. However, bind mainly to estrogen receptors, interfering with various neurologic functions, its use a topic significant concern. Nonetheless, neurotoxicity has not been fully understood despite numerous investigations on disruptive effects. Therefore, this review aims highlight recent studies implications system. Our findings suggest that exposure impairs structural molecular brain changes, promoting oxidative stress, changing expression levels several crucial genes proteins, destructive effects neurotransmitters, excitotoxicity neuroinflammation, damaged blood-brain barrier function, neuronal damage, apoptosis effects, disruption intracellular Ca

Language: Английский

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Toxicological study of metal and metal oxide nanoparticles in zebrafish

Journal of Applied Toxicology, Journal Year: 2019, Volume and Issue: 40(1), P. 37 - 63

Published: Dec. 29, 2019

Abstract Metal and metal oxide nanoparticles have been widely used in catalytic, electronic biomedical fields. It is necessary to investigate their toxicity potential hazards human aquatic ecosystems. Zebrafish ( Danio rerio ), as a promising animal model, has increasingly utilized assess the of nanoparticles. numerous characteristics for evaluation, such short life cycle high fecundity. This review describes advantages using zebrafish assessment Then we focus on toxic effects, particularly acute chronic ones, induced by zebrafish. Target organ toxicities are also mentioned, including immunotoxicity, developmental toxicity, neurotoxicity, reproductive cardiovascular hepatotoxicity. The effects selected nanoparticles, Au, Ag, Cu, TiO 2 , Al O 3 CuO, NiO ZnO, well underlying mechanisms causing these highlighted described detail. Furthermore, introduce general factors that affect nanoparticle‐induced drawbacks model nanotoxicity studies argued. Finally, suggest application joint other pollutants could be hot topics nanotoxicology.

Language: Английский

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A review of the influences of microplastics on toxicity and transgenerational effects of pharmaceutical and personal care products in aquatic environment

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 732, P. 139222 - 139222

Published: May 11, 2020

Language: Английский

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Titanium dioxide nanoparticle affects motor behavior, neurodevelopment and axonal growth in zebrafish (Danio rerio) larvae

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 754, P. 142315 - 142315

Published: Sept. 8, 2020

Language: Английский

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Progress and Prospects of Non-Metal Doped Graphitic Carbon Nitride for Improved Photocatalytic Performances

Acta Physico-Chimica Sinica, Journal Year: 2020, Volume and Issue: 36(3), P. 1905080 - 0

Published: Jan. 1, 2020

Abstract:

Language: Английский

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Zebrafish (Danio rerio) as an excellent vertebrate model for the development, reproductive, cardiovascular, and neural and ocular development toxicity study of hazardous chemicals

Environmental Science and Pollution Research, Journal Year: 2020, Volume and Issue: 27(35), P. 43599 - 43614

Published: Sept. 24, 2020

Language: Английский

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The joint effect of parental exposure to microcystin-LR and polystyrene nanoplastics on the growth of zebrafish offspring

Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 410, P. 124677 - 124677

Published: Nov. 26, 2020

Language: Английский

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Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work

Environment International, Journal Year: 2023, Volume and Issue: 176, P. 107976 - 107976

Published: May 16, 2023

Bisphenol A (BPA) is the most simple and predominant component of family. BPA widely present in environment human body as a result its extensive usage plastic epoxy resins consumer goods like water bottles, food containers, tableware. Since 1930s, when BPA's estrogenic activity was first observed, it labeled "mimic hormone E2", studies on endocrine-disrupting effects then have been conducted. As top vertebrate model for genetic developmental studies, zebrafish has caught tremendous attention past two decades. By using zebrafish, negative either through signaling pathways or non-estrogenic were largely found. In this review, we tried to draw full picture current state knowledge with their mechanisms action decades, which may help fully understand mechanism, give direction future studies.

Language: Английский

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Bisphenol A co-exposure effects: a key factor in understanding BPA’s complex mechanism and health outcomes

Critical Reviews in Toxicology, Journal Year: 2019, Volume and Issue: 49(5), P. 371 - 386

Published: May 28, 2019

Bisphenol A (BPA) is an environmental endocrine disrupting chemical widely used in the production of consumer products, such as polycarbonate plastics, epoxies, and thermal receipt paper. Human exposure to BPA ubiquitous due its high-volume use. has been associated with obesity, diabetes, reproductive disorders, cancer. Yet, molecular mechanisms or modes action underlying these disease outcomes are poorly understood pleiotropic effects induced by BPA. further confounding factor understanding BPA's impact on human health that co-exposure endogenous exogenous agents occurs during course daily life. Studies investigating their relationship adverse often ignore interactions between other chemicals present environment. This review examines studies highlight potentially unexplored possible associations attributed Importantly, both beneficial observed natural stressors vitro vivo models. These clearly influence cellular responses endpoint measures need be considered when evaluating exposures effects.

Language: Английский

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