Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
249, P. 114343 - 114343
Published: Dec. 9, 2022
UV
filters,
widely
used
in
personal
care
products,
are
ubiquitous
environmental
pollutants
detected
and
pose
a
significant
public
health
concern.
Benzophenone-3
(BP3)
titanium
dioxide
nanoparticles
(nano-TiO2)
the
predominant
organic
inorganic
filters
media.
However,
few
studies
have
explored
combined
developmental
neurotoxic
(DNT)
effects
underlying
mechanisms
when
co-exposed
to
BP3
nano-TiO2.
In
present
study,
zebrafish
(Danio
rerio)
embryos
were
exposed
environmentally
relevant
concentrations
of
(10
μg/L),
nano-TiO2
(100
mixtures
starting
from
6
h
post
fertilization
(hpf),
respectively.
Developmental
indicators
motor
behaviors
investigated
at
various
stages.
Our
results
showed
that
alone
or
with
increased
spontaneous
movement
24
hpf,
co-exposure
decreased
touch
response
30
hpf
hatching
rate
60
hpf.
Consistent
these
deficits,
inhibited
relative
axon
length
primary
neuron
during
early
stages,
disturbed
expression
axonal
growth-related
genes
48
cell
apoptosis
on
head
region
mRNA
levels
apoptosis-related
genes,
also
reactive
oxygen
species
(ROS)
zebrafish,
suggesting
functional
relevance
structural
changes.
Taken
together,
our
findings
demonstrated
combination
induced
evident
developing
zebrafish.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(16)
Published: March 27, 2022
Metal-based
nanoparticles
(NPs)
are
particularly
important
tools
in
tissue
engineering-,
drug
carrier-,
interventional
therapy-,
and
biobased
technologies.
However,
their
complex
varied
migration
transformation
pathways,
as
well
continuous
accumulation
closed
biological
systems,
cause
various
unpredictable
toxic
effects
that
threaten
human
ecosystem
health.
Considerable
experimental
theoretical
efforts
have
been
made
toward
understanding
these
cytotoxic
effects,
though
more
research
on
metal-based
NPs
integrated
with
clinical
medicine
is
required.
This
review
summarizes
the
mechanisms
evaluation
methods
of
cytotoxicity
provides
an
in-depth
analysis
typical
generated
nervous,
immune,
reproductive,
genetic
systems.
In
addition,
challenges
opportunities
discussed
to
enhance
future
investigations
safer
for
practical
commercial
adoption.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2021,
Volume and Issue:
9
Published: March 25, 2021
Electrospinning
technique
has
attracted
considerable
attention
in
fabrication
of
cellulose
nanofibrils
or
nanocellulose
membranes,
which
polycaprolactone
(PCL)
could
be
used
as
a
promising
precursor
to
prepare
various
nanofibril
membranes
for
periodontal
tissue
regeneration.
Conventional
bio-membranes
and
films
guided
regeneration
(GTR)
can
prevent
the
downgrowth
epithelial
cells,
fibroblasts,
connective
area
tooth
root
but
have
limitations
related
osteogenic
antimicrobial
properties.
Cellulose
an
ideal
drug
delivery
material
encapsulate
carry
some
drugs.
In
this
study,
magnesium
oxide
(MgO)
nanoparticles-incorporated
PCL/gelatin
core-shell
were
fabricated
using
coaxial
electrospinning
technique,
was
termed
Coaxial-MgO.
The
single-nozzle
namely
Blending-MgO
Blending-Blank,
control.
morphology
physicochemical
property
these
characterized
by
scanning
electron
microscopy
(SEM),
energy-dispersive
spectrum
X-ray
(EDS),
transmission
(TEM),
contact
angle,
thermogravimetric
analysis
(TGA).
results
showed
that
incorporation
MgO
nanoparticles
barely
affected
mechanical
membranes.
Coaxial-MgO
with
fiber
structure
had
better
hydrophilic
sustainable
release
ion
(Mg
2+
).
CCK-8
cell
proliferation
EdU
staining
demonstrated
human
ligament
stem
cells
(hPDLSCs)
rates
compared
other
group
due
its
gelatin
shell
great
biocompatibility
hydrophilicity.
SEM
immunofluorescence
assay
illustrated
scaffold
significantly
enhanced
hPDLSCs
adhesion.
vitro
antibacterial
properties
membrane
alkaline
phosphatase
(ALP)
activity,
formation
mineralized
nodules,
osteogenic-related
genes
[ALP,
collagen
type
1
(COL1),
runt-related
transcription
factor
2
(Runx2)],
high
toward
Escherichia
coli
(
E.
)
Actinobacillus
actinomycetemcomitans
A.
when
controls.
Our
findings
suggested
PCL-derived
might
prospects
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2021,
Volume and Issue:
9
Published: May 26, 2021
Lignin
from
different
biomasses
possess
biological
antioxidation
and
antimicrobial
activities,
which
depend
on
the
number
of
functional
groups
molecular
weight
lignin.
In
this
work,
organosolv
fractionation
was
carried
out
to
prepare
lignin
fraction
with
a
suitable
structure
tailor
excellent
activities.
Gel
permeation
chromatography
(GPC)
analysis
showed
that
decreased
fractions
were
obtained
by
sequentially
anhydrous
acetone,
50%
acetone
37.5%
hexanes.
Nuclear
magnetic
resonance
(NMR)
results
indicated
lower
had
fewer
substructures
higher
phenolic
hydroxyl
content,
positively
correlated
their
ability.
Both
original
fractionated
lignins
possessed
ability
inhibit
growth
Gram-negative
bacteria
(
Escherichia
coli
Salmonella
)
Gram-positive
Streptococcus
Staphylococcus
aureus
destroying
cell
wall
in
vitro
,
lowest
highest
content
(L3)
best
performance.
Besides,
L3
ameliorate
coli-induced
diarrhea
damages
mice
improve
formation
intestinal
contents
vivo
.
These
imply
tailored
bamboo
can
be
used
as
novel
agent
biomedical
field.
Water,
Journal Year:
2023,
Volume and Issue:
15(9), P. 1735 - 1735
Published: April 30, 2023
In
recent
years,
with
the
aggravation
of
environmental
pollution,
study
aquatic
ecotoxicology
has
become
a
hot
topic.
Some
organisms,
such
as
large
fleas,
toads,
and
zebrafish,
have
been
developed
applied
model
organisms.
They
increasingly
used
to
bioaccumulation
toxicity
pollutants
due
advantages
their
small
size,
easy
reproduction,
short
life
cycle,
low
maintenance
cost,
ability
combine
genetic,
cellular,
whole
organism
endpoints.
This
review
summarizes
methods
in
ecotoxicology,
using
its
developmental
toxicity,
biomarkers,
genomics,
phenotype
analysis
evaluate
pollutants,
providing
reference
value
for
researchers
select
animals
research.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3757 - 3757
Published: Feb. 13, 2023
Emamectin
benzoate
(EMB)
is
a
widely
used
pesticide
and
feed
additive
in
agriculture
aquaculture.
It
easily
enters
the
aquatic
environment
through
various
pathways,
thus
causing
adverse
effects
on
organisms.
However,
there
are
no
systematic
studies
regarding
of
EMB
developmental
neurotoxicity
Therefore,
aim
this
study
was
to
evaluate
neurotoxic
mechanisms
at
different
concentrations
(0.1,
0.25,
0.5,
1,
2,
4
8
μg/mL)
using
zebrafish
as
model.
The
results
showed
that
significantly
inhibited
hatching
rate,
spontaneous
movement,
body
length,
swim
bladder
development
embryos,
well
increased
malformation
rate
larvae.
In
addition,
adversely
affected
axon
length
motor
neurons
Tg
(hb9:
eGFP)
central
nervous
system
(CNS)
(HuC:
locomotor
behavior
Meanwhile,
induced
oxidative
damage
accompanied
by
increasing
reactive
oxygen
species
brains
gene
expression
involvement
stress-related
(cat,
sod
Cu/Zn-sod),
GABA
neural
pathway-related
(gat1,
gabra1,
gad1b,
abat
glsa),
neurodevelopmental-related
(syn2a,
gfap,
elavl3,
shha,
gap43
Nrd)
development-related
(foxa3,
pbxla,
mnx1,
has2
elovlla)
genes
exposure.
conclusion,
our
shows
exposure
during
early
life
stages
increases
inhibits
neuronal
development,
neuron
growth
ultimately
leading
neurobehavioral
changes
juvenile
zebrafish.
Environment & Health,
Journal Year:
2024,
Volume and Issue:
2(3), P. 114 - 125
Published: Feb. 7, 2024
The
escalating
frequency
of
thallium
(Tl)
contamination
incidents
amplifies
its
environmental
risk.
However,
the
potential
risk
Tl
to
aquatic
organisms,
especially
across
varying
developmental
stages,
remains
poorly
understood.
In
this
study,
we
employed
zebrafish
as
a
representative
model
organism
and
exposed
embryos
larvae
at
distinct
periods
(specifically,
6
h
postfertilization
(hpf)
72
hpf)
low
concentrations
Tl(I)
(0.25
0.50
mg/L).
exposure
was
performed
for
short
duration
24
h,
followed
by
96
depuration
period.
Our
results
revealed
that
exerted
disparate
biological
effects
on
different
stages.
Embryos
exhibited
negligible
uptake
Tl(I),
whereas
showed
significant
accumulation
struggled
with
rapid
elimination.
Notably,
able
permeate
blood-brain
barrier,
thereby
posing
nervous
system.
Transcriptomic
analysis
indicated
triggered
toxicological
pathways
in
larvae.
It
mainly
interfered
metabolic
processes
embryos,
while
larvae,
it
disrupted
intracellular
ion
homeostasis,
both
consequently
provoking
neurotoxicity.
This
emphasizes
multifaceted
nature
toxicity
depends
stages
organism.
study
clearly
shows
bioeffects
are
intricately
related
stage
zebrafish,
offering
valuable
perspective
pollutant
assessment.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1926 - 1926
Published: Feb. 5, 2024
Nanomaterials
are
widely
used
in
various
fields,
and
ongoing
research
is
focused
on
developing
safe
sustainable
nanomaterials.
Using
zebrafish
as
a
model
organism
for
studying
the
potentially
toxic
effects
of
nanomaterials
highlights
importance
Studies
conducted
their
toxicity
potential
risks
to
human
environmental
health
vital
biomedical
sciences.
In
present
review,
we
discuss
(inorganic
organic)
exposure
based
size,
shape,
concentration.
The
review
further
explores
types
impacts
at
different
levels,
indicating
that
can
lead
developmental
defects,
changes
gene
expressions,
toxicities.
also
covers
considering
natural
organic
matter
chorion
membranes
standardized
nanotoxicity
testing.
While
some
biologically
compatible,
metal
semiconductor
enter
water
environment
increase
aquatic
creatures
accumulate
body.
Further
investigations
necessary
assess
safety
health.
Journal of Applied Toxicology,
Journal Year:
2024,
Volume and Issue:
44(11), P. 1657 - 1678
Published: March 17, 2024
Abstract
Plastic
waste
comprises
polymers
of
different
chemicals
that
disintegrate
into
nanoplastic
particles
(NPLs)
1–100‐nm
size,
thereby
littering
the
environment
and
posing
a
threat
to
wildlife
human
health.
Research
on
NPL
contamination
has
up
now
focused
ecotoxicology
effects
pollution
rather
than
health
risks.
This
review
aimed
speculate
about
possible
properties
carcinogenic
neurotoxic
as
pollutants.
Given
their
low‐dimensional
size
high
surface
ratio,
NPLs
can
easily
penetrate
biological
membranes
cause
functional
structural
damage
in
cells.
Once
inside
cell,
interrupt
autophagy
flux
cellular
debris,
alter
proteostasis,
provoke
mitochondrial
dysfunctions,
induce
endoplasmic
reticulum
stress.
Harmful
metabolic
processes
induced
by
include
oxidative
stress
(OS),
ROS
generation,
pro‐inflammatory
reactions.
Depending
cell
cycle
status,
may
direct
DNA
damage,
tumorigenesis,
lately
carcinogenesis
tissues
with
self‐renewal
capabilities
like
epithelia.
In
cells
able
live
longest
neurons,
could
trigger
neurodegeneration
promoting
toxic
proteinaceous
aggregates,
OS,
chronic
inflammation.
genotoxicity
neurotoxicity
are
discussed
based
gathered
evidence,
when
available,
within
context
intracellular
uptake
these
newcomer
nanoparticles.
summary,
this
explains
how
risk
evaluation
for
benefit
from
accurately
monitoring
toxicokinetics
toxicodynamics
at
resolution
level.
