Predicting PFAS fate in fish: Assessing the roles of dietary, respiratory, and dermal uptake in bioaccumulation modeling

Environmental Research, Journal Year: 2024, Volume and Issue: 252, P. 119036 - 119036

Published: May 1, 2024

Language: Английский

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Physiologically based kinetic models for farm animals: Critical review of published models and future perspectives for their use in chemical risk assessment

Toxicology in Vitro, Journal Year: 2019, Volume and Issue: 60, P. 61 - 70

Published: May 8, 2019

Physiologically based kinetic (PBK) models in the 10 most common species of farm animals were identified through an extensive literature search. This resulted 39 PBK models, mostly for pharmaceuticals. The critically assessed using WHO criteria model evaluation, i.e. 1) purpose, 2) structure and mathematical representation, 3) computer implementation, 4) parameterisation, 5) performance, 6) documentation. Overall, calibrated validated with published data (92% 67% respectively) but only a fraction codes along manuscript (28%) local sensitivity analysis was performed without considering global analysis. Hence, reliability these is hard to assess their potential use chemical risk assessment limited. In context, future should include more generic flexible structure, input parameters independent on calibration tools performance. Development application animal would furthermore benefit from setup structured databases providing physiological chemical-specific as well enzyme expression activities support development species-specific QIVIVE models.

Language: Английский

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One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum

Environment International, Journal Year: 2021, Volume and Issue: 156, P. 106625 - 106625

Published: May 16, 2021

The use of freshwater invertebrates for biomonitoring has been increasing several decades, but little is known about relations between external exposure concentration metals and their biodistribution among different tissues. One multi-compartments toxicokinetic (TK) models are powerful tools to formalize predict how a contaminant bioaccumulated. aim this study develop modeling approaches improve knowledge on dynamic accumulation fate Cd Hg in gammarid's organs. Gammarids were exposed dissolved (11.1 ± 1.2 µg.L-1 or 0.27 0.13 Hg) before depuration phase. At each sampling days, organs (caeca, cephalon, intestine remaining tissues) separated by dissection analyses. Results allowed us determine that i) G.fossarum takes up as efficiently the mussel M.galloprovincialis, eliminates it more rapidly, ii) which accumulate depurate most, terms concentrations, caeca both metals; iii) one-compartment TK most relevant Hg, while model allows better fit data, demonstrating transfer

Language: Английский

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Organ-specific accumulation of cadmium and zinc in Gammarus fossarum exposed to environmentally relevant metal concentrations

Environmental Pollution, Journal Year: 2022, Volume and Issue: 308, P. 119625 - 119625

Published: June 14, 2022

Language: Английский

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Alternative experimental approaches to reduce animal use in biomedical studies

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 68, P. 103131 - 103131

Published: Jan. 24, 2022

Language: Английский

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