Antidepressant drugs as emerging contaminants: Occurrence in urban and non-urban waters and analytical methods for their detection

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 757, P. 143722 - 143722

Published: Nov. 14, 2020

Language: Английский

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Consumption and ocurrence of antidepressants (SSRIs) in pre- and post-COVID-19 pandemic, their environmental impact and innovative removal methods: A review

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 829, P. 154656 - 154656

Published: March 19, 2022

Language: Английский

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Emerging challenges of the impacts of pharmaceuticals on aquatic ecosystems: A diatom perspective

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 878, P. 162939 - 162939

Published: March 17, 2023

Pharmaceuticals are a ubiquitous group of emerging pollutants considerable importance due to their biological potency and potential elicit effects in wildlife humans. have been quantified terrestrial, marine, fresh, transitional waters, as well the fauna macro-flora that inhabit them. can enter water ways through different human veterinary pathways with traditional wastewater treatment, unable completely remove pharmaceuticals, discharging often unknown quantities aquatic ecosystems. However, there is paucity available information regarding pharmaceuticals on species at base food webs, especially phytoplankton, research typically focussing fish invertebrates. Diatoms one main classes phytoplankton some most abundant important organisms systems. As primary producers, diatoms generate ∼40 % world's oxygen vital source for consumers. also be used bioremediation polluted bodies but perhaps best known bio-indicators quality studies. this keystone, non-target ignored during ecotoxicological studies assess concern. Observed an indicator pharmaceutical-induced impacts higher trophic level wider ecosystem effects. The aim review present synthesis pharmaceutical exposure diatoms, considering ecotoxicity, role bio-indicators. We highlight significant omissions knowledge gaps which need addressing realise future risk assessment approaches help evaluate environment local global scales.

Language: Английский

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Global scanning of selective serotonin reuptake inhibitors: occurrence, wastewater treatment and hazards in aquatic systems

Environmental Pollution, Journal Year: 2019, Volume and Issue: 250, P. 1019 - 1031

Published: April 27, 2019

Language: Английский

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The potential for adverse effects in fish exposed to antidepressants in the aquatic environment

Environmental Science & Technology, Journal Year: 2021, Volume and Issue: 55(24), P. 16299 - 16312

Published: Dec. 2, 2021

Antidepressants are one of the most commonly prescribed pharmaceutical classes for treatment psychiatric conditions. They act via modulation brain monoaminergic signaling systems (predominantly serotonergic, adrenergic, dopaminergic) that show a high degree structural conservation across diverse animal phyla. A reasonable assumption, therefore, is exposed fish and other aquatic wildlife may be affected by antidepressants released into natural environment. Indeed, there substantial data reported exposure effects in fish, albeit concentrations exceeding those occurring environments. From critical analysis available evidence risk quotients (RQs) were derived from laboratory-based studies selection detected We conclude likelihood on standard measured end points used assessment (i.e., excluding behavior) low levels Nevertheless, some behavior have been environmentally relevant exposures, can bioaccumulate tissues. Limitations datasets to calculate RQs revealed important gaps which future research should directed more accurately assess risks posed fish. Developing greater certainty surrounding requires attention toward behaviors relating individual fitness, employment realistic levels, chronic scenarios, mixtures analyses, especially given wide range similarly acting compounds

Language: Английский

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When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms

Environmental Research, Journal Year: 2021, Volume and Issue: 205, P. 112495 - 112495

Published: Dec. 6, 2021

Pharmaceutical drugs have become consumer products, with a daily use for some of them. The volume production and consumption is such that they environmental pollutants. Their transfer to wastewater through urine, feces or rinsing in case skin use, associated partial elimination by treatment plants generalize pollution the hydrosphere, including drinking water, sediments, soils, food chain plants. Here, we review potential effects exposure three classes pharmaceutical drugs, i.e. antibiotics, antidepressants non-steroidal anti-inflammatory on neurodevelopment. Experimental studies analyzing their underlying modes action those related endocrine disruption, molecular mechanisms epigenetic modifications are presented. In addition, contribution brain imaging assessment adverse these pharmaceuticals approached.

Language: Английский

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Antidepressants in Surface Waters: Fluoxetine Influences Mosquitofish Anxiety-Related Behavior at Environmentally Relevant Levels

Environmental Science & Technology, Journal Year: 2019, Volume and Issue: 53(10), P. 6035 - 6043

Published: April 29, 2019

Pharmaceutical contamination is an increasing problem globally. In this regard, the selective serotonin reuptake inhibitors (SSRIs)-a group of antidepressants-are particularly concerning. By disrupting serotonergic system, SSRIs have potential to affect ecologically important behaviors in exposed wildlife. Despite this, nature and magnitude behavioral perturbations resulting from environmentally relevant SSRI exposure among species poorly understood. Accordingly, we investigated effects two field-realistic levels fluoxetine (61 352 ng/L) on sociability anxiety-related eastern mosquitofish ( Gambusia holbrooki) for 28 days. Additionally, measured whole-body tissue concentrations norfluoxetine. We found that altered behavior but not sociability. Specifically, female fish showed reduced at lower treatment level, while males increase higher level. addition, report a biomass-dependent sex-specific accumulation norfluoxetine, with smaller showing relative concentrations, relationship being more pronounced males. Our study provides evidence nonmonotonic concentrations. More broadly, our demonstrated neuroactive pharmaceuticals, such as fluoxetine, can aquatic life by causing subtle shifts behaviors.

Language: Английский

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Proximate causes and ultimate effects of common antidepressants, fluoxetine and venlafaxine, on fish behavior

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 807, P. 150846 - 150846

Published: Oct. 7, 2021

Language: Английский

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Long-Term Pharmaceutical Contamination and Temperature Stress Disrupt Fish Behavior

Environmental Science & Technology, Journal Year: 2020, Volume and Issue: 54(13), P. 8072 - 8082

Published: June 18, 2020

Natural environments are subject to a range of anthropogenic stressors, with pharmaceutical pollution being among the fastest-growing agents global change. However, despite wild animals living in complex multi-stressor environments, interactions between exposure and other stressors remain poorly understood. Accordingly, we investigated effects long-term pervasive contaminant fluoxetine (Prozac) acute temperature stress on reproductive behaviors activity levels guppy (Poecilia reticulata). Fish were exposed environmentally realistic concentrations (measured average: 38 or 312 ng/L) solvent control for 15 months using mesocosm system. Additionally, fish subjected one three (24 h) treatments: cold (18 °C), heat (32 °C). We found no evidence interactive behavior. both had independent impacts. Fluoxetine resulted increased male coercive copulatory behavior, while unaffected. Under cold-temperature stress, sexes less active males exhibited frequent behaviors. Our results demonstrate that common pollutant alter fundamental fitness-related fish, potentially shifting population dynamics contaminated ecosystems.

Language: Английский

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Effects of fluoxetine on fish: What do we know and where should we focus our efforts in the future?

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 857, P. 159486 - 159486

Published: Oct. 17, 2022

Fluoxetine is one of the most studied and detected selective serotonin reuptake inhibitors in aquatic environment, found at concentrations ranging from ng/L to μg/L. Its presence this environment can induce effects on organisms that may compromise their fitness. Several experimental studies have demonstrated fluoxetine neurotoxicity, genetic biochemical changes, cause behavioral dysfunction a wide range fish species. However, contradictory results be found. There thus need for comprehensive review current state knowledge different levels biological organization, highlighting inclusive patterns discussing potential causes results, available literature. This also aims explore identify main gaps areas future research. We conclude environmentally relevant (e.g., 0.00345 μg/L) produced adverse often concentration not addressed conventional environmental risk assessment strategies. persistence ionizable properties reinforce standardized testing with representative models, targeting endpoints sensitive specific mode action fluoxetine, order assess rank its actual ecosystems.

Language: Английский

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