Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(8), P. 3156 - 3165
Published: Feb. 13, 2023
Fluorescent
brighteners
(FBs)
are
a
group
of
mass-produced
dyestuff
chemicals
that
have
been
extensively
used
for
decades.
However,
knowledge
their
occurrence
in
municipal
wastewater
treatment
plants
on
large
geographical
scale
remains
unknown.
Herein,
we
implemented
the
first
nationwide
survey
wastewater-derived
FBs
sludge
across
major
cities
China.
All
25
target
were
detected
sludge.
Ionic
exhibited
much
higher
concentrations
than
nonionic
FBs.
The
total
(∑25FBs)
ranged
from
7300
to
1,520,000
ng/g,
with
median
35,300
ng/g.
A
clear
distribution
significantly
was
found
East
and
Central
China
West
(p
<
0.05).
∑25FBs
correlated
well
gross
domestic
product
(GDP)
population
size
at
provincial
level
0.05),
demonstrating
significance
anthropogenic
impacts
FB
levels
urban
annual
emission
into
is
estimated
be
835
tons/year,
which
134
tons/year
directly
released
sludge-applied
soils.
Our
work
highlights
another
new
class
contribute
chemical
mixtures
thus
require
immediate
attention.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(23), P. 10309 - 10321
Published: May 25, 2024
The
global
practice
of
reusing
sewage
sludge
in
agriculture
and
its
landfill
disposal
reintroduces
environmental
contaminants,
posing
risks
to
human
ecological
health.
This
study
screened
from
30
Chinese
cities
for
androgen
receptor
(AR)
disruptors,
utilizing
a
disruptor
list
the
Toxicology
21st
Century
program
(Tox21),
identified
25
agonists
33
antagonists
across
diverse
use
categories.
Predominantly,
natural
products
5α-dihydrotestosterone
thymidine
emerged
as
agonists,
whereas
industrial
intermediate
caprolactam
was
principal
antagonist.
In-house
bioassays
disruptors
displayed
good
alignment
with
Tox21
potency
data,
validating
employing
toxicity
data
theoretical
estimations.
Potency
calculations
revealed
two
pharmaceuticals
(17β-trenbolone
testosterone
isocaproate)
most
potent
AR
three
dyes
(rhodamine
6G,
Victoria
blue
BO,
gentian
violet)
antagonists.
Theoretical
effect
contribution
evaluations
prioritized
isocaproate
high-risk
caprolactam,
rhodamine
8-hydroxyquinoline
(as
biocide
preservative)
key
Notably,
16
20
were
newly
reported
sludge,
many
exhibiting
significant
detection
frequencies,
concentrations,
and/or
toxicities,
demanding
future
scrutiny.
Our
presents
an
efficient
strategy
estimating
sample
identifying
toxicants,
thereby
supporting
development
appropriate
management
strategies.
Environment International,
Journal Year:
2020,
Volume and Issue:
136, P. 105428 - 105428
Published: Jan. 7, 2020
Triclosan
(TCS)
has
been
widely
used
as
an
antibacterial
agent
for
the
last
several
decades
in
personal
care
products.
The
toxicological
effect
of
TCS
attracted
more
and
attention
researchers.
purpose
this
study
is
to
evaluate
cytotoxic
effects
HepG2
cells
elucidate
molecular
mechanism
focusing
on
regulation
phosphatidylinositol
3-kinase
(PI3K)/protein
kinase
B
(Akt)/forkhead
box
O
(FoxO)
pathway
glycolytic
metabolism.
In
study,
we
evaluated
adverse
exposure
cell
viability,
reactive
oxygen
species
(ROS)
generation,
superoxide
dismutase
(SOD)
activity
mitochondrial
membrane
potential
(MMP).
addition,
glycolysis
process
exposed
was
examined
terms
glucose
consumption,
lactate
production
ATP
generation.
Furthermore,
Affymetrix
Human
U133
plus
2.0
gene
chips
function
enrichment
analysis
were
conducted
screen
differential
expression
genes
(DEGs)
signaling
pathway.
Expressions
glycolysis-related
proteins
measured
quantified
with
Western
Blotting.
results
showed
that
could
suppress
induce
oxidative
stress,
cause
damage.
promoted
process,
manifested
by
accelerated
conversion
increased
energy
release.
Blotting
confirmed
levels
related
significantly
elevated.
PI3K/Akt/FoxO
identified
play
a
pivot
role
TCS-induced
glycolysis,
which
further
inhibitor
tests
using
specific
inhibitors
LY294002
MK2206.
general,
can
damages
promote
cells,
mediated
