Zebrafish models of fetal alcohol spectrum disorders DOI
Yohaan Fernandes, C. Ben Lovely

genesis, Journal Year: 2021, Volume and Issue: 59(11)

Published: Nov. 1, 2021

Abstract Fetal alcohol spectrum disorder (FASD) describes a wide range of structural deficits and cognitive impairments. FASD impacts up to 5% children born in the United States each year, making ethanol one most common teratogens. Due limitations ethical concerns, studies humans are limited their ability study FASD. Animal models have proven critical identifying characterizing mechanisms underlying In this review, we will focus on attributes zebrafish that make it strong model which ethanol‐induced developmental defects. Zebrafish several an ideal produced large numbers externally fertilized, translucent embryos. With high degree genetic amenability, at forefront gene‐ethanol interactions underlie Work from multiple labs has shown embryonic exposures result defects craniofacial, cardiac, ocular, neural development. addition defects, behavioral impairments been studied zebrafish. Building upon these studies, work identified ethanol‐sensitive loci However, analyses show there is still much be learned interactions. The ideally suited expand our understanding impact Because conservation gene function between humans, directly translate candidate genes human populations allow for better diagnosis treatment

Language: Английский

Alanine aminotransferase detection using TIT assisted four tapered fiber structure-based LSPR sensor: From healthcare to marine life DOI
Ragini Singh, Zhi Wang, Carlos Marques

et al.

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 236, P. 115424 - 115424

Published: May 23, 2023

Language: Английский

Citations

110
Exploring Cr(VI)-induced blood-brain barrier injury and neurotoxicity in zebrafish and snakehead fish, and inhibiting toxic effects of astaxanthin DOI
Muyang Li,

Yan-Chao Shi,

Wan-Xin Xu

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 355, P. 124280 - 124280

Published: May 28, 2024

Language: Английский

Citations

25
Effects of Pollution on Fish Behavior, Personality, and Cognition: Some Research Perspectives DOI Creative Commons
Lisa Jacquin, Quentin Petitjean, Jessica Côte

et al.

Frontiers in Ecology and Evolution, Journal Year: 2020, Volume and Issue: 8

Published: April 7, 2020

Pollutants, and more generally, environmental stressors, are a neglected source of behavioral cognitive variations in wild populations. Based on recent literature fish, we highlight four interesting research perspectives to better understand the effects pollutants links between behavior, cognition fitness. First, (1) review neurotoxic fish personality cognition. These could turn affect level exposure pollutants, potentially generating feedback loops that may amplify Second, propose (2) should be studied multistress context, i.e. realistic conditions combination with other because some stressors Third (3), existing studies show physiological traits often linked syndromes. Pollutants lead syndrome disruption, which evolutionary trajectories exposed Future thus focus complex consequences trajectories. Fourth, (4) chronic pollution local (mal)adaptation, result into high intraspecific variability sensitivity among In addition, responses constrain, or constrained by stressors. We encourage future use integrative approaches bridge gap ecotoxicology, ecology framework improve our ability predict anthropogenic wildlife.

Language: Английский

Citations

120
Approaches to Test the Neurotoxicity of Environmental Contaminants in the Zebrafish Model: From Behavior to Molecular Mechanisms DOI

Jennifer A. Fitzgerald,

Sarah Könemann,

Laura Krümpelmann

et al.

Environmental Toxicology and Chemistry, Journal Year: 2020, Volume and Issue: 40(4), P. 989 - 1006

Published: Dec. 3, 2020

Abstract The occurrence of neuroactive chemicals in the aquatic environment is on rise and poses a potential threat to biota currently unpredictable outcome. In particular, subtle changes caused by these an organism's sensation or behavior are difficult tackle with current test systems that focus rodents vitro omit whole‐animal responses. recent years, zebrafish ( Danio rerio ) has become popular model organism for toxicological studies testing strategies, such as standardized use early life stages Organisation Economic Co‐operation Development's guideline 236. terms neurotoxicity, provides powerful investigate nervous system from several different angles, offering ability mechanisms action detail. mechanistic understanding gained through analysis this species good basic knowledge how might interact teleost system. Such information can help infer effects occurring other exposed their predicting risks chemical ecosystem. present article, we highlight approaches ranging behavioral structural, functional, molecular larval system, providing holistic view neurotoxic outcomes. Environ Toxicol Chem 2021;40:989–1006. © 2020 SETAC

Language: Английский

Citations

105
New understanding of novel brominated flame retardants (NBFRs): Neuro(endocrine) toxicity DOI Creative Commons

Liying Dong,

Shutao Wang, Jinze Qu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 208, P. 111570 - 111570

Published: Nov. 13, 2020

Traditional brominated flame retardants (BFRs) negatively affect the environment and human health, especially in sensitive (developing) nervous system. Considering physicochemical similarities between novel (NBFRs) BFRs, more evidence reveals neurotoxic effects of NBFRs. We reviewed neuro(endocrine) toxic NBFRs vivo vitro discussed their action mechanisms based on available information. The potential has been demonstrated through direct neurotoxicity disruption neuroendocrine system, with adverse neurobehavioral reproductive development. Mechanistic studies have shown that impact is related to complex interaction neural endocrine signals. From disrupting gender differentiation brain, altering serum thyroid/sex hormone levels, gene/protein expression, so on, interfere feedback effect different levels HPG/HPT axis. In this paper, mechanism explored from a new perspective-neuro interactions. Gaps toxicity data system are supplemented provide broader dataset for complete risk assessment.

Language: Английский

Citations

83
Long-term exposure to polyethylene microplastics and glyphosate interferes with the behavior, intestinal microbial homeostasis, and metabolites of the common carp (Cyprinus carpio L.) DOI
Jianjun Chen, Chenyang Rao,

Rongjie Yuan

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 814, P. 152681 - 152681

Published: Dec. 29, 2021

Language: Английский

Citations

80
Exposure of adult zebrafish (Danio rerio) to Tetrabromobisphenol A causes neurotoxicity in larval offspring, an adverse transgenerational effect DOI
Yunjiang Yu,

Yunbo Hou,

Yao Dang

et al.

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 414, P. 125408 - 125408

Published: Feb. 15, 2021

Language: Английский

Citations

62
Long-term exposure of zebrafish (Danio rerio) to Cr(VI): Reproductive toxicity and neurotoxicity DOI
Lei Zhao,

Hengxuan Duan,

Yihan Liu

et al.

Regional Studies in Marine Science, Journal Year: 2024, Volume and Issue: 74, P. 103559 - 103559

Published: April 30, 2024

Language: Английский

Citations

11
Effects of oxybenzone on zebrafish behavior and cognition DOI
Ana Luisa Pires Moreira, Ana Carolina Luchiari

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 808, P. 152101 - 152101

Published: Dec. 2, 2021

Language: Английский

Citations

41
Selenium toxicity in fishes: A current perspective DOI Creative Commons
Md. Helal Uddin, Jinnath Rehana Ritu, Sravan Kumar Putnala

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143214 - 143214

Published: Aug. 29, 2024

Anthropogenic activities have led to increased levels of contaminants that pose significant threats aquatic organisms, particularly fishes. One such contaminant is Selenium (Se), a metalloid which released by various industrial including mining and fossil fuel combustion. crucial for physiological functions, however it can bioaccumulate become toxic at elevated concentrations. Given fishes are key predators in ecosystems major protein source humans, Se accumulation raises considerable ecological food safety concerns. induces toxicity the cellular level disrupting balance between reactive oxygen species (ROS) production antioxidant capacity leading oxidative damage. Chronic exposure impairs wide range critical functions metabolism, growth reproduction. also potent teratogen types adverse developmental effects fishes, mainly due its maternal transfer eggs. Moreover, persist across generations. Furthermore, Se-induced stress brain driver neurotoxicity, leads impairment several ecologically important behaviours cognition memory social preference interactions, anxiety response. Our review provides an up-to-date in-depth analysis while identifying knowledge gaps need be addressed future research greater insights into impact ecosystems.

Language: Английский

Citations

6