Journal of Environmental Science and Health Part B,
Journal Year:
2023,
Volume and Issue:
58(9), P. 603 - 615
Published: Aug. 21, 2023
Benzophenone
(BP-3)
is
an
organic
compound
that
a
common
ingredient
in
lotions,
conditioners,
and
other
personal
care
products,
which
helps
protect
against
ultraviolet
radiation.
This
study
investigated
the
effect
of
BP-3
on
structure
integument
gills,
as
well
activities
superoxide
dismutase
(SOD)
catalase
(CAT)
gills
Danio
rerio.
Fish
were
exposed
to
different
concentrations
(7,
70,
700
µg
L-1)
for
7
14
d.
For
histological
analysis
fish
fixed
Bouin
liquid
processed
according
standard
histologic
procedures,
tissue
section
slices
stained
histochemical
methods.
caused
damage
morphological
alterations
gills;
however,
showed
no
or
alterations.
Furthermore,
there
was
observed
correlation
between
concentration
exposure
period
gill
alterations,
these
did
not
occur
linear
manner.
The
removed
evaluate
antioxidant
defense;
this,
CAT
SOD
measured,
reduction
activity
noted,
whereas
significantly
affected.
Eco-Environment & Health,
Journal Year:
2023,
Volume and Issue:
3(1), P. 30 - 44
Published: Oct. 19, 2023
Benzophenone
ultraviolet
light
filters
(BPs)
are
high-production-volume
chemicals
extensively
used
in
personal
care
products,
leading
to
widespread
human
exposure.
Given
their
estrogenic
properties,
the
potential
health
risks
associated
with
exposure
BPs
have
become
a
public
concern.
This
review
aims
summarize
sources
and
pathways
of
risks.
Dermal
exposure,
primarily
through
use
sunscreens,
constitutes
major
pathway
for
BP
At
recommended
application
rate,
dermal
BP-3
via
sunscreens
may
reach
or
exceed
suggested
reference
dose.
Other
BPs,
such
as
drinking
water,
seafood,
packaged
foods,
contribute
minimal
overall
Inhalation
is
minor
exposure;
however,
its
contribution
cannot
be
ignored.
Human
an
order
magnitude
higher
North
America
than
Asia
Europe.
Studies
conducted
on
laboratory
animals
cells
consistently
demonstrated
toxic
effects
elicit
reproductive
developmental
toxicities.
Furthermore,
neurotoxicity,
hepatotoxicity,
nephrotoxicity,
carcinogenicity
been
reported
from
chronic
In
addition
animal
cell
studies,
epidemiological
investigations
identified
associations
between
couples'
fecundity
other
disorders,
well
adverse
birth
outcomes.
Further
studies
urgently
needed
understand
posed
by
health.
Frontiers in Behavioral Neuroscience,
Journal Year:
2022,
Volume and Issue:
16
Published: June 13, 2022
Alzheimer’s
disease
(AD)
has
become
increasingly
prevalent
in
the
elderly
population
across
world.
It’s
pathophysiological
markers
such
as
overproduction
along
with
accumulation
of
amyloid
beta
(Aβ)
plaques
and
neurofibrillary
tangles
(NFT)
are
posing
a
serious
challenge
to
novel
drug
development
processes.
A
model
which
simulates
human
neurodegenerative
mechanism
will
be
beneficial
for
rapid
screening
potential
candidates.
Due
comparable
neurological
network
humans,
zebrafish
emerged
promising
AD
model.
This
been
thoroughly
validated
through
research
aspects
neuronal
pathways
analogous
brain.
The
cholinergic,
glutamatergic,
GABAergic
pathways,
play
role
manifested
behavior
zebrafish,
well
defined.
There
several
behavioral
models
both
adult
larvae
establish
various
cognitive
impairment
including
spatial
memory,
associative
anxiety,
other
features
that
AD.
eliminates
shortcomings
previously
recognized
mammalian
models,
terms
expense,
extensive
assessment
durations,
complexity
imaging
brain
test
efficacy
therapeutic
interventions.
review
highlights
analyze
changes
normal
patterns
when
exposed
inducing
agents.
mechanistic
pathway
adopted
by
drugs
strategies
can
explored
via
these
their
slow
progression
evaluated.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(2), P. 160 - 160
Published: Feb. 18, 2024
Diflubenzuron
(DFB)
and
pyriproxyfen
(PPF)
are
larvicides
used
in
crops
to
control
insect
plagues.
However,
these
pesticides
known
impact
non-target
organisms
like
fish
mammals.
Here,
we
aimed
at
assessing
the
embryotoxicity
of
purified
DFB,
PPF,
their
mixtures
a
organism—zebrafish.
Zebrafish
embryos
were
exposed
different
concentrations
for
120
h:
0.025,
0.125,
0.25,
1.25,
2.5,
10
mg/L
PPF
while
0.025
+
DFB
(Mix
A),
0.125
B),
0.25
C)
DFB.
We
observed
mortality,
teratogenicity,
cardiotoxicity.
For
neurotoxicity
tests
evaluation
reactive
oxygen
species
(ROS)
levels
brain,
h
0.379
0.754
established
LC50
as
3.79
mg/L,
was
not
determinable.
Survival
hatching
affected
by
above
1.25
lower
pesticide
mixtures.
exposure
induced
types
malformations,
higher
number
malformations
mixtures,
suggesting
potentiating
effect.
Pesticides
diminished
avoidance
responses
increased
ROS
across
all
concentrations,
indicating
neurotoxicity.
Our
findings
underscore
detrimental
exposure,
spanning
from
biochemistry
morphology.
There
is
critical
need
reconsider
global
use
transition
more
ecologically
friendly
forms
pest
control,
raising
an
alarm
regarding
repercussions
on
human
animal
health
well-being.
