genesis,
Journal Year:
2021,
Volume and Issue:
59(11)
Published: Nov. 1, 2021
Abstract
Fetal
alcohol
spectrum
disorder
(FASD)
describes
a
wide
range
of
structural
deficits
and
cognitive
impairments.
FASD
impacts
up
to
5%
children
born
in
the
United
States
each
year,
making
ethanol
one
most
common
teratogens.
Due
limitations
ethical
concerns,
studies
humans
are
limited
their
ability
study
FASD.
Animal
models
have
proven
critical
identifying
characterizing
mechanisms
underlying
In
this
review,
we
will
focus
on
attributes
zebrafish
that
make
it
strong
model
which
ethanol‐induced
developmental
defects.
Zebrafish
several
an
ideal
produced
large
numbers
externally
fertilized,
translucent
embryos.
With
high
degree
genetic
amenability,
at
forefront
gene‐ethanol
interactions
underlie
Work
from
multiple
labs
has
shown
embryonic
exposures
result
defects
craniofacial,
cardiac,
ocular,
neural
development.
addition
defects,
behavioral
impairments
been
studied
zebrafish.
Building
upon
these
studies,
work
identified
ethanol‐sensitive
loci
However,
analyses
show
there
is
still
much
be
learned
interactions.
The
ideally
suited
expand
our
understanding
impact
Because
conservation
gene
function
between
humans,
directly
translate
candidate
genes
human
populations
allow
for
better
diagnosis
treatment
Environmental Pollution,
Journal Year:
2024,
Volume and Issue:
347, P. 123685 - 123685
Published: March 7, 2024
Boscalid
(2-Chloro-N-(4′-chlorobiphenyl-2-yl)
nicotinamide),
a
pyridine
carboxamide
fungicide,
is
an
inhibitor
of
the
complex
II
respiration
chain
in
fungal
mitochondria.
As
boscalid
only
moderately
toxic
for
aquatic
organisms
(LC50
>
1–10
mg/L),
current
environmental
levels
this
compound
ecosystems,
range
ng/L-μg/L,
are
considered
safe
organisms.
In
study,
we
have
exposed
zebrafish
(Danio
rerio),
Japanese
medaka
(Oryzias
latipes)
and
Daphnia
magna
to
concentrations
(1–1000
μg/L)
24
h,
effects
on
heart
rate
(HR),
basal
locomotor
activity
(BLA),
visual
motor
response
(VMR),
startle
(SR),
habituation
(HB)
series
vibrational
or
light
stimuli
been
evaluated.
Moreover,
changes
profile
main
neurotransmitters
determined.
altered
HR
concentration-dependent
manner,
leading
positive
negative
chronotropic
effect
fish
D.
magna,
respectively.
While
decreased
BLA
increased
VMR
Daphnia,
these
behaviors
were
not
fish.
For
SR
HB,
was
more
species-
concentration-specific,
with
exhibiting
highest
sensitivity.
At
neurotransmission
level,
exposure
L-aspartic
acid
larvae
dopaminergic
metabolites
magna.
Our
study
demonstrates
that
alters
cardiac
activity,
impairs
ecologically
relevant
behaviors,
leads
different
neurotransmitter
systems
phylogenetically
distinct
vertebrate
invertebrate
models.
Thus,
results
presented
emphasize
need
review
regulation
fungicide.
genesis,
Journal Year:
2021,
Volume and Issue:
59(11)
Published: Nov. 1, 2021
Abstract
Fetal
alcohol
spectrum
disorder
(FASD)
describes
a
wide
range
of
structural
deficits
and
cognitive
impairments.
FASD
impacts
up
to
5%
children
born
in
the
United
States
each
year,
making
ethanol
one
most
common
teratogens.
Due
limitations
ethical
concerns,
studies
humans
are
limited
their
ability
study
FASD.
Animal
models
have
proven
critical
identifying
characterizing
mechanisms
underlying
In
this
review,
we
will
focus
on
attributes
zebrafish
that
make
it
strong
model
which
ethanol‐induced
developmental
defects.
Zebrafish
several
an
ideal
produced
large
numbers
externally
fertilized,
translucent
embryos.
With
high
degree
genetic
amenability,
at
forefront
gene‐ethanol
interactions
underlie
Work
from
multiple
labs
has
shown
embryonic
exposures
result
defects
craniofacial,
cardiac,
ocular,
neural
development.
addition
defects,
behavioral
impairments
been
studied
zebrafish.
Building
upon
these
studies,
work
identified
ethanol‐sensitive
loci
However,
analyses
show
there
is
still
much
be
learned
interactions.
The
ideally
suited
expand
our
understanding
impact
Because
conservation
gene
function
between
humans,
directly
translate
candidate
genes
human
populations
allow
for
better
diagnosis
treatment
