Triclosan Influences on Reproductive Physiology of Climbing Perch in the Spawning Phase DOI Creative Commons

C. V. Priyatha,

K. C. Chitra

Croatian Journal of Fisheries, Journal Year: 2022, Volume and Issue: 80(2), P. 47 - 66

Published: June 1, 2022

Abstract The endocrine-disrupting effects of triclosan, an antimicrobial agent, and its involvement in reproductive responses mediated through different modes activity various fish species have been documented. present study aims to explore whether triclosan at environmentally relevant sublethal concentrations could influence the physiology Anabas testudineus spawning phase. Fish were exposed (0.009 9 µg L −1 ) (176.7 for 4, 7, 30 60 d during phase evaluating potential fish. Triclosan exposure caused a significant ( P <0.05) reduction level total protein gonads liver tissues while increasing blood plasma meet energy demand overcome metabolic stress. Impairment gonadal steroidogenesis was evidenced by activities 3β- 17β-hydroxysteroid dehydrogenases associated with alteration levels serum gonadotropins, sex steroid hormones vitellogenin. rate fecundity females declined sperm counts, motility viability males. Histological lesions further confirmed toxicity which turn contribute failure

Language: Английский

Adverse effects of triclosan exposure on health and potential molecular mechanisms DOI Open Access
Xuhui Chen, Mou Li, Jiayuan Qu

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 879, P. 163068 - 163068

Published: March 23, 2023

Language: Английский

Citations

47
Adsorption behaviors of triclosan by non-biodegradable and biodegradable microplastics: Kinetics and mechanism DOI
Ke Shi, Hong Zhang,

HaoMing Xu

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 842, P. 156832 - 156832

Published: June 26, 2022

Language: Английский

Citations

52
Long-term exposure of zebrafish (Danio rerio) to Cr(VI): Reproductive toxicity and neurotoxicity DOI
Lei Zhao,

Hengxuan Duan,

Yihan Liu

et al.

Regional Studies in Marine Science, Journal Year: 2024, Volume and Issue: 74, P. 103559 - 103559

Published: April 30, 2024

Language: Английский

Citations

12
Gill histological and transcriptomic analysis provides insights into the response of spotted sea bass (Lateolabrax maculatus) to alkalinity stress DOI

Yonghang Zhang,

Haishen Wen, Yang Liu

et al.

Aquaculture, Journal Year: 2022, Volume and Issue: 563, P. 738945 - 738945

Published: Oct. 17, 2022

Language: Английский

Citations

36
Study on the toxic-mechanism of triclosan chronic exposure to zebrafish (Danio rerio) based on gut-brain axis DOI
Yang Wang, Jie Song,

Xuedong Wang

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 844, P. 156936 - 156936

Published: June 27, 2022

Language: Английский

Citations

33
Response pathways of superoxide dismutase and catalase under the regulation of triclocarban-triggered oxidative stress in Eisenia foetida: Comprehensive mechanism analysis based on cytotoxicity and binding model DOI

Zhihan Cui,

Falin He, Xiangxiang Li

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 854, P. 158821 - 158821

Published: Sept. 16, 2022

Language: Английский

Citations

32
Triclosan-induced glycolysis drives inflammatory activation in microglia via the Akt/mTOR/HIF 1α signaling pathway DOI Creative Commons
Jieyu Liu, Rui Feng, Dan Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2021, Volume and Issue: 224, P. 112664 - 112664

Published: Aug. 17, 2021

Exposure to triclosan (TCS) has been implicated in neurotoxicity including autism spectrum disorders vivo and oxidative stress cell apoptosis vitro. Thus, the molecular mechanisms underlying TCS-induced warrants further research. In this study, we try address mode of action that TCS induced expression inflammatory cytokines by shifting metabolism glycolysis. BV-2 cells were treated with 20 μM for 24 h, conditional medium from activated microglia reduced viability murine hippocampal neurons line HT22. Protein levels nuclear factor kappa B (NF-κB) signaling pathway measured through Western blotting, cytokine using quantitative real-time PCR. The results showed exposure enhanced NF-κB activation, increased interleukin (IL) 1β, IL-6, tumor necrosis (TNF) α cells. glucose consumption lactate production BV2 sharply after h. Based on our qPCR blotting results, key glycolysis enzymes—namely hexokinase 1, pyruvate kinase M2, dehydrogenase A—increased treatment TCS. Furthermore, inhibiting 2-deoxy-D-glucose activation mRNA TCS-activated microglia. proteins Akt/mTOR/HIF1α examined which regulates glycolysis, also exposed Moreover, Akt mTOR inhibition LY294002 rapamycin, respectively, blocked overexpression conclusion, can induce directly drive microglia; mediation pathway.

Language: Английский

Citations

32
Effects of chronic triclosan exposure on social behaviors in adult mice DOI
Ying Hao, Meng Li, Yan Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 424, P. 127562 - 127562

Published: Oct. 21, 2021

Language: Английский

Citations

30
Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis DOI Creative Commons
Xiaoqian Wang, Jia Zhang,

Xueyi Rao

et al.

Chinese Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Background: The CUG-binding protein Elav-like family member 2 ( CELF2 ) gene has been linked to the pathogenesis of epilepsy, but its precise role remains unclear. This study aimed investigate pathogenic mechanisms mutation in utilizing zebrafish models explore molecular pathways and biological impact. Methods: Whole-exome sequencing was performed identify mutations associated with epilepsy. model were generated using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-related 9 technology morpholinos, followed by behavioral electroencephalographic analyses confirm epileptic phenotypes. Proteomic metabolomic conducted examine impact deficiency on metabolic pathways, single-cell used assess alterations neuronal cell populations. Results: An infant infantile spasms syndrome a p.Pro520Arg reported. We established celf2 knockout knockdown found that exhibited epilepsy-like behaviors, which could be rescued injection wild-type mRNA. Significant changes observed crucial marker genes nervous system +/− group, including FOS , BDNF NPAS4 GABRA1 GABRG2 PYYA . Disruptions lipid metabolism, heat shock 90 beta1 (Hsp90b1), identified proteomic analyses. Single-cell showed nucleosome localization, DNA binding, arginine proline gonadotropin-releasing hormone signaling pathway, nucleotide-binding oligomerization domain receptor pathway. Conclusions: Our revealed promising association between defects epilepsy model, suggesting CLEF2 is causative These findings not only indicate potential process influenced defect also offer hopeful insights into therapeutic targets.

Language: Английский

Citations

0
Temperature- and chemical-induced neurotoxicity in zebrafish DOI Creative Commons
Mattia Toni, Chiara Arena,

Carla Cioni

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 3, 2023

Throughout their lives, humans encounter a plethora of substances capable inducing neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests when exposure to these chemicals disrupts the normal functioning nervous system, some agents have been linked neurodegenerative pathologies such as Parkinson's Alzheimer's disease. The growing concern surrounding impacts both naturally occurring man-made toxic necessitates identification animal models for rapid testing across wide spectrum concentrations, utilization tools detecting system alterations spanning from molecular level up behavioural one. Zebrafish (Danio rerio) is gaining prominence in field neuroscience due its versatility. possibility analysing all developmental stages (embryo, larva adult), applying most common "omics" approaches (transcriptomics, proteomics, lipidomics, etc.) conducting range tests makes zebrafish an excellent model neurotoxicity studies. This review delves into main experimental adopted markers analysed studies zebrafish, showing that phenomena can be triggered not only by chemical but also fluctuations temperature. findings presented here serve valuable resource study define new scenarios ecotoxicology suggesting temperature synergistically compound effects substances, intensifying detrimental impact on fish populations.

Language: Английский

Citations

10