Metformin: update on mechanisms of action and repurposing potential

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(8), P. 460 - 476

Published: May 2, 2023

Language: Английский

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A nationwide study of occurrence and exposure assessment of neonicotinoid insecticides and their metabolites in drinking water of China

Water Research, Journal Year: 2020, Volume and Issue: 189, P. 116630 - 116630

Published: Nov. 10, 2020

Language: Английский

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Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications

Pharmacological Research, Journal Year: 2022, Volume and Issue: 177, P. 106114 - 106114

Published: Feb. 3, 2022

Language: Английский

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Metformin as an emerging concern in wastewater: Occurrence, analysis and treatment methods

Environmental Research, Journal Year: 2022, Volume and Issue: 213, P. 113613 - 113613

Published: June 10, 2022

Language: Английский

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Optimization of Sibipiruna activated carbon preparation by simplex-centroid mixture design for simultaneous adsorption of rhodamine B and metformin

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 411, P. 125166 - 125166

Published: Jan. 18, 2021

Language: Английский

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Metformin Contamination in Global Waters: Biotic and Abiotic Transformation, Byproduct Generation and Toxicity, and Evaluation as a Pharmaceutical Indicator

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(19), P. 13528 - 13545

Published: Sept. 15, 2022

Metformin is the first-line antidiabetic drug and one of most prescribed medications worldwide. Because its ubiquitous occurrence in global waters demonstrated ecotoxicity, metformin, as with other pharmaceuticals, has become a concerning emerging contaminant. subject to transformation, producing numerous problematic transformation byproducts (TPs). The occurrence, removal, toxicity metformin have been continually reviewed; yet, comprehensive analysis pathways, byproduct generation, associated change adverse effects lacking. In this review, we provide critical overview fate during water treatments natural processes compile 32 organic TPs generated from biotic abiotic pathways. These occur aquatic systems worldwide along metformin. Enhanced several compared through organism tests necessitates development complete mineralization techniques for more attention on TP monitoring. We also assess potential indicate overall contamination pharmaceuticals environments, previously acknowledged ones, found be robust or comparable indicator such pharmaceutical contamination. addition, insightful avenues future research

Language: Английский

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Aerobic Degradation of the Antidiabetic Drug Metformin by Aminobacter sp. Strain NyZ550

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(3), P. 1510 - 1519

Published: Jan. 9, 2023

Metformin is becoming one of the most common emerging contaminants in surface and wastewater. Its biodegradation generally leads to accumulation guanylurea environment, but microorganisms mechanisms involved this process remain elusive. Here, Aminobacter sp. strain NyZ550 was isolated characterized for its ability grow on metformin as a sole source carbon, nitrogen, energy under oxic conditions. This isolate also assimilated variety nitrogenous compounds, including dimethylamine. Hydrolysis by accompanied stoichiometric dead-end product. Based ion chromatography, gas chromatography–mass spectrometry, comparative transcriptomic analyses, dimethylamine identified an additional hydrolytic product supporting growth strain. Notably, microbial mixture consisting engineered Pseudomonas putida PaW340 expressing hydrolase constructed complete elimination persistent guanylurea. Overall, our results not only provide new insights into pathway, leading commonly observed open doors degradation pollutant metformin.

Language: Английский

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Study on triphase of polymorphs TiO2 (anatase/rutile/brookite) for boosting photocatalytic activity of metformin degradation

Chemosphere, Journal Year: 2024, Volume and Issue: 351, P. 141206 - 141206

Published: Jan. 12, 2024

Language: Английский

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Promoted removal of metformin hydrochloride anti-diabetic drug from water by fabricated and modified nanobiochar from artichoke leaves

Sustainable Chemistry and Pharmacy, Journal Year: 2020, Volume and Issue: 18, P. 100336 - 100336

Published: Oct. 19, 2020

Language: Английский

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The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment – Review

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 412, P. 125028 - 125028

Published: Jan. 11, 2021

Language: Английский

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