Combined effects of micropollutants and their degradation on prokaryotic communities at the sediment–water interface DOI Creative Commons

Adrien Borreca,

Stéphane Vuilleumier, Gwenaël Imfeld

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 22, 2024

Pesticides and pharmaceuticals enter aquatic ecosystems as complex mixtures. Various processes govern their dissipation effect on the sediment surface waters. These micropollutants often show persistence can adversely affect microorganisms even at low concentrations. We investigated effects procaryotic communities of metformin (antidiabetic drug), metolachlor (agricultural herbicide), terbutryn (herbicide in building materials). contaminants were introduced individually or a mixture (17.6 µM per micropollutant) into laboratory microcosms mimicking sediment-water interface. Metformin completely dissipated within 70 days, whereas persisted. Dissipation did not differ whether part mixture. Sequence analysis 16S rRNA gene amplicons evidenced distinct responses prokaryotic both water. Prokaryotic community variations mainly driven by matrix composition incubation time. Micropollutant exposure played secondary but influential role, with pronounced recalcitrant micropollutant Antagonistic synergistic non-additive identified for specific taxa across taxonomic levels response to This study underscores importance considering diversity interactions between micropollutants, communities, respective environments when examining interfaces affected multiple contaminants.

Language: Английский

Metformin: update on mechanisms of action and repurposing potential DOI Open Access
Marc Foretz, Bruno Guigas, Benoı̂t Viollet

et al.

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(8), P. 460 - 476

Published: May 2, 2023

Language: Английский

Citations

339
Fabrication of magnetic chitosan-grafted salicylaldehyde/nanoclay for removal of azo dye: BBD optimization, characterization, and mechanistic study DOI
Laili Azmiati Arni, Ahmad Hapiz, Ali H. Jawad

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 248, P. 125943 - 125943

Published: July 22, 2023

Language: Английский

Citations

39
Design of separable magnetic chitosan grafted-benzaldehyde for azo dye removal via a response surface methodology: Characterization and adsorption mechanism DOI
Laili Azmiati Arni, Ahmad Hapiz, Ahmed Saud Abdulhameed

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 125086 - 125086

Published: May 27, 2023

Language: Английский

Citations

31
Emerging organic contaminants in the River Ganga and key tributaries in the middle Gangetic Plain, India: Characterization, distribution & controls DOI Creative Commons
Laura A. Richards, Shuaizhi Guo, Dan Lapworth

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 327, P. 121626 - 121626

Published: April 11, 2023

The presence and distribution of emerging organic contaminants (EOCs) in freshwater environments is a key issue India globally, particularly due to ecotoxicological potential antimicrobial resistance concerns. Here we have investigated the composition spatial EOCs surface water along ∼500 km segment iconic River Ganges (Ganga) tributaries middle Gangetic Plain Northern India. Using broad screening approach, 11 samples, identified 51 EOCs, comprising pharmaceuticals, agrochemicals, lifestyle industrial chemicals. Whilst majority detected were mixture pharmaceuticals chemicals (and sucralose) occurred at highest concentrations. Ten are priority compounds (e.g. sulfamethoxazole, diuron, atrazine, chlorpyrifos, perfluorooctane sulfonate (PFOS), perfluorobutane sulfonate, thiamethoxam, imidacloprid, clothianidin diclofenac). In almost 50% sulfamethoxazole concentrations exceeded predicted no-effect (PNECs) for ecological toxicity. A significant downstream reduction was observed Ganga between Varanasi (Uttar Pradesh) Begusarai (Bihar), likely reflecting dilution effects associated with three major tributaries, all considerably lower EOC than main channel. Sorption and/or redox controls some clopidol), as well relatively high degree mixing within river. We discuss environmental relevance persistence several parent (notably carbamazepine, metribuzin fipronil) transformation products. Associations other hydrochemical parameters including excitation emission matrix (EEM) fluorescence indicated positive, significant, compound-specific correlations tryptophan-, fulvic- humic-like fluorescence. This study expands baseline characterization Indian contributes an improved understanding sources on large river systems.

Language: Английский

Citations

28
Aerobic Degradation of the Antidiabetic Drug Metformin by Aminobacter sp. Strain NyZ550 DOI
Tao Li,

Zhi-Jing Xu,

Ning‐Yi Zhou

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(3), P. 1510 - 1519

Published: Jan. 9, 2023

Metformin is becoming one of the most common emerging contaminants in surface and wastewater. Its biodegradation generally leads to accumulation guanylurea environment, but microorganisms mechanisms involved this process remain elusive. Here, Aminobacter sp. strain NyZ550 was isolated characterized for its ability grow on metformin as a sole source carbon, nitrogen, energy under oxic conditions. This isolate also assimilated variety nitrogenous compounds, including dimethylamine. Hydrolysis by accompanied stoichiometric dead-end product. Based ion chromatography, gas chromatography–mass spectrometry, comparative transcriptomic analyses, dimethylamine identified an additional hydrolytic product supporting growth strain. Notably, microbial mixture consisting engineered Pseudomonas putida PaW340 expressing hydrolase constructed complete elimination persistent guanylurea. Overall, our results not only provide new insights into pathway, leading commonly observed open doors degradation pollutant metformin.

Language: Английский

Citations

25
Water Analysis: Emerging Contaminants and Current Issues DOI
Susan D. Richardson, Tarek Manasfi

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(20), P. 8184 - 8219

Published: May 3, 2024

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTWater Analysis: Emerging Contaminants and Current IssuesSusan D. Richardson*Susan RichardsonDepartment of Chemistry Biochemistry, University South Carolina, JM Palms Center for GSR, 631 Sumter Street, Columbia, Carolina 29208, United States*[email protected]More by Susan RichardsonView Biographyhttps://orcid.org/0000-0001-6207-4513 Tarek ManasfiTarek ManasfiEawag, Environmental Chemistry, Uberlandstrasse 133, Dubendorf 8600, SwitzerlandMore ManasfiView BiographyCite this: Anal. Chem. 2024, 96, 20, 8184–8219Publication Date (Web):May 3, 2024Publication History Received16 March 2024Accepted16 April 2024Revised14 2024Published online3 May inissue 21 2024https://pubs.acs.org/doi/10.1021/acs.analchem.4c01423https://doi.org/10.1021/acs.analchem.4c01423review-articleACS PublicationsCopyright © 2024 American Chemical SocietyRequest reuse permissionsArticle Views826Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Drinking water,Extraction,Impurities,Liquid chromatography,Mass spectrometry Get e-Alerts

Language: Английский

Citations

13
Electro-oxidation of Ibuprofen using carbon-supported SnOx-CeOx flow-anodes: The key role of high-valent metal DOI
Huachang Jin, Xiaozhi Xu,

Renlan Liu

et al.

Water Research, Journal Year: 2024, Volume and Issue: 252, P. 121229 - 121229

Published: Jan. 29, 2024

Language: Английский

Citations

7
Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes DOI
Lambros J. Tassoulas, Joel A. Rankin, Mikael Elias

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(10)

Published: Feb. 26, 2024

Metformin is the first-line treatment for type II diabetes patients and a pervasive pollutant with more than 180 million kg ingested globally entering wastewater. The drug's direct mode of action currently unknown but linked to effects on gut microbiomes may involve specific microbial reactions drug. In wastewater plants, metformin known be transformed by microbes guanylurea, although genes encoding this metabolism had not been elucidated. present study, we revealed function two responsible decomposition (

Language: Английский

Citations

7
Wastewater bacteria remediating the pharmaceutical metformin: Genomes, plasmids and products DOI Creative Commons
Betsy M. Martínez-Vaz,

Anthony G. Dodge,

Rachael M. Lucero

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: Dec. 16, 2022

Metformin is used globally to treat type II diabetes, has demonstrated anti-ageing and COVID mitigation effects a major anthropogenic pollutant be bioremediated by wastewater treatment plants (WWTPs). not adsorbed well activated carbon toxic N-chloro derivatives can form in chlorinated water. Most earlier studies on metformin biodegradation have consortia details of the genomes, relevant genes, metabolic products, potential for horizontal gene transfer are lacking. Here, two metformin-biodegrading bacteria from WWTP were isolated their characterized. Aminobacter sp. MET metabolized stoichiometrically guanylurea, an intermediate known accumulate some environments including WWTPs. Pseudomonasmendocina completely utilized all nitrogen atoms growth. Pseudomonas mendocina also breakdown products sometimes observed WWTPs: 1-N-methylbiguanide, biguanide, guanidine. The genome each bacterium was obtained. Genes involved transport guanylurea expressed heterologously shown serve as antiporter expel guanidinium compound. A novel hydrolase enzyme identified MET, purified, contained one plasmid 160 kb 90 kb, respectively. In total, these significant bioremediation WWTPs today.

Language: Английский

Citations

19
Deep Eutectic Solvent-Assisted Synthesis of a Strontium Tungstate Bifunctional Catalyst: Investigation on the Electrocatalytic Determination and Photocatalytic Degradation of Acetaminophen and Metformin Drugs DOI

Jeena N. Baby,

Balasubramanian Akila,

Te‐Wei Chiu

et al.

Inorganic Chemistry, Journal Year: 2023, Volume and Issue: 62(21), P. 8249 - 8260

Published: May 18, 2023

In this work, we propose a modified solid-state approach for the sustainable preparation of SrWO4 bifunctional catalyst using thymol-menthol-based natural deep eutectic green solvents (NADESs). Various spectroscopic and morphological techniques analyzed as-synthesized particles. Acetaminophen (ATP) metformin (MTF) were selected as model drug compounds. The electrochemical detection photocatalytic degradation ATP MTF upon ultraviolet-visible (UV-vis) light irradiation in presence as-prepared particles an active are examined. present study displayed that proposed has enhanced catalytic activity achieving optimum experimental conditions, linear ranges = 0.01-25.90 μM μM, lower limit (LOD) value (ATP 0.0031 0.008 μM), higher sensitivity toward determination obtained. Similarly, rate constant was found to be k 0.0082 min-1 0.0296 according Langmuir-Hinshelwood model, benefitting from excellent synergistic impact molecule. Hence, work offers innovative insights into applicability functional material remediation emerging pollutants water bodies with recovery range 98.2-99.75%.

Language: Английский

Citations

13