Sensory-Motor Perturbations in Larval Zebrafish (Danio rerio) Induced by Exposure to Low Levels of Neuroactive Micropollutants during Development DOI Open Access
Jason Henry, Yutao Bai, Florian Kreuder

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 8990 - 8990

Published: Aug. 12, 2022

Due to increasing numbers of anthropogenic chemicals with unknown neurotoxic properties, there is an need for a paradigm shift toward rapid and higher throughput behavioral bioassays. In this work, we demonstrate application purpose-built high multidimensional test battery on larval stages Danio rerio (zebrafish) at 5 days post fertilization (dpf). The automated comprised the established spontaneous swimming (SS), simulated predator response (SPR), photomotor (LPR) assays as well new thermotaxis (TX) assay. We applied novel system characterize environmentally relevant concentrations emerging pharmaceutical micropollutants including anticonvulsants (gabapentin: 400 ng/L; carbamazepine: 3000 ng/L), inflammatory drugs (ibuprofen: 9800 antidepressants (fluoxetine: 300 venlafaxine: 2200 ng/L). successful integration thermal preference assay into provided means reveal ibuprofen-induced perturbations behaviors upon exposure during embryogenesis. Moreover, discovered that responses in fish are also altered by yet understudied anticonvulsant gabapentin. Collectively our results utility high-throughput ecotoxicity batteries prioritizing risks associated neuroactive can perturb neurodevelopment. showcase added value bioassays preliminary screening contaminants.

Language: Английский

Environmental and health impact of unrecovered API from pharmaceutical manufacturing wastes: A review of contemporary treatment, recycling and management strategies DOI
Emmanuel Sunday Okeke, Timothy Prince Chidike Ezeorba, Charles Obinwanne Okoye

et al.

Sustainable Chemistry and Pharmacy, Journal Year: 2022, Volume and Issue: 30, P. 100865 - 100865

Published: Oct. 11, 2022

Language: Английский

Citations

42
Synthesis and its characterization of silver sulfide/nickel titanate/chitosan nanocomposites for photocatalysis and water splitting under visible light, and antibacterial studies DOI
Jing Wang, Jiayi Sun, Jing‐Fang Huang

et al.

Materials Chemistry and Physics, Journal Year: 2021, Volume and Issue: 272, P. 124990 - 124990

Published: July 12, 2021

Language: Английский

Citations

52
Assessing the size-dependent effects of microplastics on zebrafish larvae through fish lateral line system and gut damage DOI
Sang A. Kim, Lia Kim, Tae Hee Kim

et al.

Marine Pollution Bulletin, Journal Year: 2022, Volume and Issue: 185, P. 114279 - 114279

Published: Oct. 29, 2022

Language: Английский

Citations

30
Enhanced desorption of fluoxetine from polyethylene terephthalate microplastics in gastric fluid and sea water DOI Creative Commons
Antony Wagstaff, Bruce Petrie

Environmental Chemistry Letters, Journal Year: 2022, Volume and Issue: 20(2), P. 975 - 982

Published: Feb. 10, 2022

Abstract There are concerns that microplastics act as a vector of pharmaceuticals in the aquatic environment. Most studies have focussed on pharmaceutical adsorption and not investigated desorption various matrices enter. Therefore we studied antidepressant drug fluoxetine from polyethylene terephthalate (PET) river water, sea simulated gastric intestinal fluids. We found most occurred rapidly, within few hours exposure. Fluoxetine fitted well to Freundlich isotherm with r 2 values ranging 0.97 0.99. Desorption decreased following order: fluid at 20 °C 37 °C; water then °C. The little difference gastrointestinal fluids suggests similar exposure risk cold- warm-blooded organisms PET microplastic ingestion. Total sequential incubation h 4 mimic digestion was 37% 41% Interestingly, higher 18–23% compared 4–11%. Under worst-case scenario, more than 44 mg kg −1 body weight d or 52 respectively, need be consumed exceed mammalian acceptable daily intake for fluoxetine. Further needed ingestion bioavailability adsorbed range exposed organisms.

Language: Английский

Citations

29
A series of MgAl layer double hydroxide-based materials intercalated with Clitoria ternatea flower extract as photocatalysts in the ciprofloxacin degradation DOI Creative Commons

Rohmatullaili,

Nur Ahmad,

Dila Savira

et al.

Chemical Physics Impact, Journal Year: 2024, Volume and Issue: 8, P. 100587 - 100587

Published: March 27, 2024

The preparation of MgAl Layer Double Hydroxide (LDH) was performed using the coprecipitation method. Pristine LDH calcined at 500°C to produce Oxide (LDO). two materials were modified via restacking-delaminating bioactive compounds from flower extract Clitoria ternatea (CT) LDH-CT and LDO-CT. Modifications are enhance stability catalyst structure, allowing its higher photocatalytic activities regeneration use. prepared catalysts characterized XRD, FT-IR, UV-DRS, BET, SEM-EDX. XRD diffraction pattern showed that three have typical patterns commonly observed in LDH-based materials. FT-IR spectra confirmed LDO-CT combined precursor has lowest bandgap energy with highest degradation kinetics. BET SEM-EDX characterization shows uniform surface pore size on used ciprofloxacin photodegradation under UV light. optimal dose 5 mg, while pH 5. LDO-CT, LDH-CT, capacity up 73.300%, 65.739%, 71.320%, respectively, within 120 minutes. Repeated use third cycle resulted %R reaching 80.871%, 74.003%, 52.025%, by LDH. Compared pristine LDH, CT intercalated exhibited more excellent stability.

Language: Английский

Citations

6
New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish DOI
Lei Lei, Biran Zhu, Kun Qiao

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 822, P. 153623 - 153623

Published: Feb. 4, 2022

Language: Английский

Citations

27
Laccase covalently immobilized on avocado seed biochar: A high-performance biocatalyst for acetaminophen sorption and biotransformation DOI

Chrys K. Hoinacki da Silva,

Allan dos Santos Polidoro,

Pedro Miguel Cabrera Ruschel

et al.

Journal of environmental chemical engineering, Journal Year: 2022, Volume and Issue: 10(3), P. 107731 - 107731

Published: April 15, 2022

Language: Английский

Citations

22
Hierarchical mesoporous plasmonic Pd-Fe3O4/NiFe-LDH composites: Characterization, and kinetic study of a photodegradation … DOI Creative Commons

Forouzan Shabib,

Razieh Fazaeli,

Hamid Aliyan

et al.

Environmental Technology & Innovation, Journal Year: 2022, Volume and Issue: 27, P. 102515 - 102515

Published: March 29, 2022

With the primary objective to develop efficient, environmentally benign, visible-light-driven heterogeneous catalysts for degradation of metoclopramide (MCP), a waste-water pollutant, newly prepared composite Pd-Fe3O4/NiFe-LDH catalyst is reported. This material has been characterized with wide range analysis methods (i.e. XRD, SEM-EDS, BET, FTIR, TG-DTG, DTA, DRUV and TEM analysis). When applied aqueous solutions MCP, displayed photocatalytic MCP an efficiency 95.2% in 80 min. The rate this was higher than that pure NiFe-LDH or Fe3O4/NiFe-LDH. best activity obtained at pH 6.5, 0.4 g/L catalyst. Application Arrhenius equation yielded activation energy process 13.4 kJ/mol. A negative ΔS‡ (-0.25 kJ/mol) positive ΔH‡ ΔG‡ values were photodegradation.

Language: Английский

Citations

20
Chronic Effects of Fluoxetine on Danio rerio: A Biochemical and Behavioral Perspective DOI Creative Commons
Daniela Correia, Inês Domingues, Melissa Faria

et al.

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(4), P. 2256 - 2256

Published: Feb. 21, 2022

Fluoxetine is an antidepressant widely used to treat depressive and anxiety states. Due its mode of action in the central nervous system (selective serotonin reuptake inhibitor (SSRI)), it becomes toxic non-target organisms, leading changes that are harmful their survival. In this work, effects fluoxetine on juvenile zebrafish (Danio rerio) were evaluated, assessing biochemical (phase II biotransformation—glutathione S-transferase (GST), neurotransmission—acetylcholinesterase (ChE), energy metabolism—lactate dehydrogenase (LDH), oxidative stress—glutathione peroxidase (GPx)) behavior endpoints (swimming behavior, social thigmotaxis) after 21 days exposure 0 (control), 0.1, 1 10 µg/L. Biochemically, although chronic did not induce significant neurotransmission metabolism, GPx activity was decreased µg/L fluoxetine. At a behavioral level, exploratory affected. However, swimming pattern exposed fish observed light dark periods (decreased locomotor activity). Overall, data show chronically may exhibit changes, affecting ability respond environmental stressors interaction with other fish.

Language: Английский

Citations

19
Long-Term Exposure to SSRI Citalopram Induces Neurotoxic Effects in Zebrafish DOI
Xiangsheng Hong, Rui Chen, Le Zhang

et al.

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(17), P. 12380 - 12390

Published: Aug. 19, 2022

Residual antidepressants are of increasing concern worldwide, yet critical information on their long-term neurotoxic impacts nontarget aquatic animals is lacking. Here, we investigated the effects (from 0 to 150 days postfertilization) selective serotonin reuptake inhibitor citalopram (0.1–100 μg/L) motor function, learning, and memory in zebrafish over two generations explored reversibility effect F1 larvae. Unlike F0+ larvae, found that F1+ larvae displayed decreased sensorimotor performance when continuously exposed at 100 μg/L. No adverse were F1– after they transferred a clean medium. Whole-mount immunofluorescence assays suggested impairments related axonal projections spinal neurons (MNs). For adults, exposure mainly caused male-specific declines motor, performance. Analysis serotonergic cholinergic MNs revealed no significant changes male cord. In contrast, number glutamatergic decreased, likely associated with impairment function. Additionally, treatment μg/L significantly reduced dopaminergic neurons, but neuronal apoptosis was observed adult telencephalon. Overall, this study provides neurobehavioral evidence novel insights into mechanisms may facilitate assessment environmental health risks posed by citalopram-containing antidepressant drugs.

Language: Английский

Citations

19