Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(7), P. 3121 - 3143
Published: May 30, 2024
Environmental
impacts
of
the
industrial
revolution
necessitate
adoption
sustainable
practices
in
all
areas
development.
The
pharmaceutical
industry
faces
increasing
pressure
to
minimize
its
ecological
footprint
due
significant
contribution
environmental
pollution.
Over
past
two
decades,
cocrystals
have
received
immense
popularity
their
ability
optimize
critical
attributes
active
ingredients
and
presented
an
avenue
bring
improved
drug
products
market.
This
review
explores
potential
as
ecofriendly
alternative
traditional
solid
forms,
offering
a
approach
From
reducing
number
required
doses
improving
stability
actives,
from
eliminating
synthetic
operations
using
pharmaceutically
approved
chemicals,
use
continuous
solvent-free
manufacturing
methods
leveraging
published
data
on
safety
toxicology,
cocrystallization
contributes
sustainability
latest
trends
suggest
promising
role
bringing
novel
medicines
market,
which
has
been
further
fuelled
by
recent
guidance
major
regulatory
agencies.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(3), P. 1562 - 1574
Published: Jan. 1, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
has
become
a
serious
public
health
issue
due
to
changing
dietary
patterns
and
composition.
However,
the
relationship
between
NAFLD
occurrence
food
additives,
such
as
preservatives,
remains
unknown.
This
study
aimed
evaluate
toxicity
of
parabens,
namely
methylparaben
(MeP)
ethylparaben
(EtP),
in
relation
mice
under
different
conditions.
Exposure
MeP
EtP
exacerbated
high-fat
diet
(HFD)-induced
obesity,
glucose
intolerance,
higher
serum
lipid
concentrations,
fat
accumulation
by
upregulating
genes
involved
metabolism.
Untargeted
metabolomics
revealed
that
arachidonic
acid
(AA)
metabolism
was
top
enriched
pathway
upon
exposure
presence
HFD.
11,12-Epoxyeicosatrienoic
(11,12-EET)
most
abundant
AA
metabolite
significantly
reduced
or
EtP.
Moreover,
an
integrative
analysis
differential
fecal
taxa
at
genus
level
metabolites
significant
associations.
In
addition,
enhanced
AML12
cells
HepG2
cultured
with
oleic
acid.
11,12-EET
supplementation
could
alleviate
suppressing
expression
metabolism-related
proteins.
The
present
suggests
chronic
promoted
Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
231, P. 113175 - 113175
Published: Jan. 7, 2022
Paraben
preservatives
have
been
listed
as
emerging
pollutants
due
to
their
ubiquity
in
various
environmental
matrices,
especially
the
water
bodies.
How
efficiently
and
practically
eliminate
these
paraben
is
therefore
of
great
importance.
Herein,
a
designed
S-scheme
heterojunction
photocatalyst,
consisting
graphitic
carbon
nitride
(g-C3N4)
monoclinic
bismuth
vanadate
(BiVO4),
was
fabricated
by
facile
hydrothermal
synthesis
employed
treat
benzyl-paraben
(BzP).
TEM
XPS
analysis
testified
intimate
interaction
between
g-C3N4
BiVO4,
consequently
smoothed
interfacial
charge
transfer
rendered
feasible
recombination
photoexcited
electrons
(from
BiVO4)
holes
g-C3N4).
The
as-established
system
enabled
left
BiVO4
maintain
high
redox
abilities
accelerated
separation
concurrently.
In
particular,
g-C3N4/BiVO4
composite
generated
much
higher
photocurrent
response
compared
with
pure
highlighting
improved
photoinduced
charges.
Therefore,
under
visible
light
natural
solar
irradiation,
showed
significantly
enhanced
photocatalytic
degradation
BzP,
which
further
optimized
5
wt%
composite.
According
Mott-Schottky
plots
identified
active
species,
mechanism
illustrated.
addition,
during
process,
acute
toxicity
reaction
solutions
on
zebrafish
embryos
notably
reduced.
conclusion,
demonstrated
strategy
enhance
performance
designing
heterostructure
may
provide
more
insights
into
development
high-efficiency
photocatalyst
towards
energy
utilization
treatment.
Furthermore,
had
proved
be
an
efficient
method
for
eliminating
ecological
risk
pollutants,
warranting
attention
future
work.
Chemical Engineering Journal,
Journal Year:
2022,
Volume and Issue:
453, P. 139631 - 139631
Published: Oct. 7, 2022
The
presence
of
emerging
contaminants
(ECs)
in
aquatic
systems
and,
particularly,
wastewater
(WW)
has
become
a
major
concern
over
the
past
years.
Among
these
contaminants,
parabens,
belonging
to
group
endocrine
disruptors,
are
used
on
daily
basis
as
preservatives
and
constantly
enter
environment,
being
called
pseudo-persistent
contaminants.
Parabens
have
potential
bioaccumulate
can
be
toxic
species.
Unfortunately,
traditional
methods
treatment
plants
(WWTPs),
namely
adsorption
process,
activated
sludge
advanced
oxidation
processes
(AOPs)
not
effective
removing
this
type
These
generate
wastes
with
high
concentrations
parabens
adsorbed
carbon,
large
amounts
containing
and/or
chemically
unstable
by-products.
To
overcome
limitations,
microalgae-based
bioremediation
aroused
great
interest
an
sustainable
process
where
microalgae
metabolism
carbon
source
(diauxic
growth).
However,
several
factors
that
affect
growth
consequently,
their
capacity,
must
considered
for
implementation
biological
treatment.
This
study
reviews
impact
environments
(ecotoxicity,
bioaccumulation
persistence)
well
limitations
current
applied
WWTPs
considering
removal
mechanisms
by-product
formation.
Moreover,
it
also
addresses
metabolic
pathways
environmental
(i.e.
nutrients
concentration,
irradiation,
photoperiod,
pH
temperature)
removal.
As
such,
review
provides
set
conditions
influence
bioremediation,
highlighting
ability
requirement
supplementary
research.
Chemical Engineering Journal,
Journal Year:
2022,
Volume and Issue:
442, P. 136374 - 136374
Published: April 13, 2022
The
rising
concerns
from
environmental
contamination
by
emerging
contaminants
(ECs)
pushes
the
need
to
develop
efficient
removal
technologies
in
wastewater
(WW)
treatment
plants.
Parabens
are
synthetic
estrogens
belonging
ECs
group
of
endocrine
disrupting
chemicals.
Microalgae-based
bioremediation
is
gaining
attention
as
a
compelling
solution
for
cost-effective
and
sustainable
WW
treatment.
However,
there
lack
scientific
data
regarding
capacity
microalgae
parabens
at
different
concentrations
well
mechanisms
involved.
This
work
aims
study
effects
methylparaben
(MetP)
exposure
0.796
7.96
mg/L
(10
100
×
higher
than
maximum
found
influent)
on
ability
Chlorella
vulgaris
remove
MetP
nutrients
WW.
mechanistic
was
undertaken
using
physiological
endpoints:
cellular
hydrophobicity
(as
extracellular
interaction),
metabolic
activity,
intracellular
reactive
oxygen
species
(ROS)
accumulation
photosynthetic
efficiency.
presence
did
not
alter
C.
cells,
which
suggests
that
bioadsorption
occur.
Moreover,
mg
MetP/L
no
were
observed
metabolism
or
biomass
production.
mg/L,
decrease
esterase
activity
pigments
production
observed,
linking
these
with
growth.
After
168
h,
partly
removed:
33.16%
14.10%,
initial
respectively.
For
lower
concentration,
achieved
through
biodegradation
photodegradation,
however,
extreme
capable
biodegrade
MetP,
being
photodegradation
main
mechanism.
Furthermore,
showed
satisfactory
growth
(≥73%),
affected
highlighting
this
microalga
contaminated
parabens,
even
concentrations.
