Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea

Chemosphere, Journal Year: 2023, Volume and Issue: 341, P. 140070 - 140070

Published: Sept. 7, 2023

Language: Английский

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Effects of Metformin and its Metabolite Guanylurea on Fathead Minnow (Pimephales promelas) Reproduction

Environmental Toxicology and Chemistry, Journal Year: 2022, Volume and Issue: 41(11), P. 2708 - 2720

Published: Aug. 3, 2022

Metformin, along with its biotransformation product guanylurea, is commonly observed in municipal wastewaters and subsequent surface waters. Previous studies fish have identified metformin as a potential endocrine-active compound, but there are inconsistencies regard to effects. To further investigate the reproductive toxicity of guanylurea fish, series experiments was performed adult fathead minnows (Pimephales promelas). First, explants minnow ovary tissue were exposed 0.001-100 µM or whether compounds could directly perturb steroidogenesis. Second, spawning pairs (0.41, 4.1, 41 µg/L) (1.0, 10, 100 for 23 days assess impacts on reproduction. Lastly, male µg/L metformin, mixture both compounds, samples collected over 96-h time course hepatic transcriptome metabolome. Neither nor affected steroid production by ex vivo. In exposure, neither compound significantly impacted transcription endocrine-related genes liver gonad, circulating concentrations either sex, fecundity pairs. course, µg guanylurea/L elicited more differentially expressed than metformin/L showed greatest at 96 h. Hepatic metabolome changes chemical- time-dependent, largest impact exposure guanylurea/L. Overall, did not elicit effects consistent environmentally relevant concentrations. Environ Toxicol Chem 2022;41:2708-2720. © 2022 SETAC. This article has been contributed U.S. Government employees their work public domain USA.

Language: Английский

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Co-occurrence, toxicity, and biotransformation pathways of metformin and its intermediate product guanylurea: Current state and future prospects for enhanced biodegradation strategy

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 921, P. 171108 - 171108

Published: Feb. 22, 2024

Language: Английский

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Chronic intake of an enriched diet with spirulina (Arthrospira maxima) alleviates the embryotoxic effects produced by realistic concentrations of tetracycline in Danio rerio

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 859, P. 159731 - 159731

Published: Nov. 7, 2022

Language: Английский

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Acute exposure to 17-α-ethinylestradiol disrupt the embryonic development and oxidative status of Danio rerio

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2021, Volume and Issue: 251, P. 109199 - 109199

Published: Oct. 2, 2021

Language: Английский

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