Journal of Environmental Science and Health Part B,
Journal Year:
2023,
Volume and Issue:
58(9), P. 603 - 615
Published: Aug. 21, 2023
Benzophenone
(BP-3)
is
an
organic
compound
that
a
common
ingredient
in
lotions,
conditioners,
and
other
personal
care
products,
which
helps
protect
against
ultraviolet
radiation.
This
study
investigated
the
effect
of
BP-3
on
structure
integument
gills,
as
well
activities
superoxide
dismutase
(SOD)
catalase
(CAT)
gills
Danio
rerio.
Fish
were
exposed
to
different
concentrations
(7,
70,
700
µg
L-1)
for
7
14
d.
For
histological
analysis
fish
fixed
Bouin
liquid
processed
according
standard
histologic
procedures,
tissue
section
slices
stained
histochemical
methods.
caused
damage
morphological
alterations
gills;
however,
showed
no
or
alterations.
Furthermore,
there
was
observed
correlation
between
concentration
exposure
period
gill
alterations,
these
did
not
occur
linear
manner.
The
removed
evaluate
antioxidant
defense;
this,
CAT
SOD
measured,
reduction
activity
noted,
whereas
significantly
affected.
Toxicology Reports,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101999 - 101999
Published: March 1, 2025
Jambolan
(Syzygium
cumini
(L.)
Skeels)
is
an
important
source
of
phenolic
compounds,
especially
anthocyanins,
known
for
their
biological
properties.
This
study
investigated
the
acute
toxicity
jambolan
hydroalcoholic
extract
(JE)
in
zebrafish
(Danio
rerio)
at
different
life
stages.
JE,
obtained
from
freeze-dried
fruits,
was
analyzed
by
high-performance
liquid
chromatography
(HPLC)
and
found
to
be
rich
total
compounds
(TPC).
A
15
were
identified
HPLC
extracts,
mainly
anthocyanins
(≈
82
%
TPC),
JE
presented
relevant
antioxidant
properties
vitro
tests.
Exposure
concentrations
between
50
200
µg/ml
resulted
increased
malformations
mortality
both
embryos
adult
zebrafish,
doses
300
400
lethal
animals.
Lethal
(LC50)
estimated
118.4
68.86
adults.
Despite
no
significant
cardiovascular
or
neurological
toxicities,
behavioral
impacts
observed
lower
(10
µg/ml),
indicating
a
nonmonotonic
concentration-response
curve.
Our
findings
suggest
that
moderate
(around
25
µg/ml)
are
safe
zebrafish;
however,
further
studies
needed
ensure
its
safety
efficacy
under
health
conditions
exposure
regimes.
Journal of Neuroinflammation,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Nov. 9, 2023
Abstract
This
study
investigated
chronic
and
repeated
sleep
deprivation
(RSD)-induced
neuronal
changes
in
hexosamine
biosynthetic
pathway/
O
-linked
N-acetylglucosamine
(HBP/
-GlcNAc)
cycling
of
glucose
metabolism
further
explored
the
role
altered
-GlcNAc
promoting
neurodegeneration
using
an
adult
zebrafish
model.
RSD-triggered
degenerative
brain
led
to
impairment
memory,
neuroinflammation
amyloid
beta
(Aβ)
accumulation.
Metabolite
profiling
RSD
revealed
a
significant
decrease
glucose,
indicating
potential
association
between
RSD-induced
dysregulated
metabolism.
While
had
no
impact
on
overall
-GlcNAcylation
levels
hippocampus
region,
were
observed
two
-GlcNAcylation-regulating
enzymes,
specifically,
transferase
(OGT)
increase
-GlcNAcase
(OGA).
Glucosamine
(GlcN)
treatment
induced
recovery
OGT
level
that
was
decreased
group.
In
addition,
GlcN
reversed
cognitive
by
RSD.
reduced
attenuated
Aβ
accumulation
Repeated
with
diazo-5-oxo-l-norleucine
(DON),
inhibitor
HBP
metabolism,
resulted
dysfunction,
accumulation,
similar
effects
The
pathological
DON
restored
normal
upon
GlcN.
Both
SD
DON-treated
groups
exhibited
common
glutamate
γ-aminobutyric
acid
compared
control
Overexpression
rescued
dysfunction
neurodegeneration.
precursor
protein
β-secretase
activity,
which
treatment.
Based
collective
findings,
we
propose
dysregulation
plays
crucial
RSD-mediated
progression
Alzheimer’s
disease
pathogenesis.
Targeting
this
pathway
may,
therefore,
offer
effective
regulatory
approach
for
sleep-associated
neurodegenerative
disorders.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(2), P. 125 - 125
Published: Feb. 2, 2024
Plastic
additives
that
maintain
integrity
have
been
extensively
studied
for
potential
toxicity
to
fish;
however,
chemicals
protect
polymers
from
(artificial)
UV
degradation
are
less
studied.
Benzotriazole
stabilizers
(BUVSs)
the
most
widely
used
in
plastics
and
often
sunscreens,
cosmetics,
paint,
food
packaging.
BUVSs
can
negatively
affect
aquatic
wildlife
when
released
into
environment
via
plastic
degradation.
In
this
review,
we
summarize
distribution
of
globally
discuss
neurotoxicological
endpoints
measured
fish
understand
how
these
neurological
health
teleost
fishes.
detected
environments
at
concentrations
ranging
0.05
up
99,200
ng/L.
Studies
show
behavioral
responses
acetylcholinesterase
activity,
indicators
neurotoxicity.
Our
computational
analysis
using
transcriptome
data
suggests
certain
pathways
associated
with
neurodegeneration
responsive
exposure
BUVSs,
like
“Complement
Activation
Alzheimer’s
Disease”.
Based
on
our
identify
some
research
needs
future
investigations:
(1)
molecular
studies
central
nervous
system
define
precise
mechanisms
neurotoxicity;
(2)
a
wider
range
tests
assessing
aberrant
behaviors
given
activity
larval
zebrafish;
(3)
histopathology
accompany
biochemical
analyses.
These
expected
enhance
understanding
neurotoxicity
benzotriazoles
other
additives.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
273, P. 116107 - 116107
Published: Feb. 20, 2024
Arsenic,
a
common
metal-like
substance,
has
been
demonstrated
to
pose
potential
health
hazards
and
induce
behavioral
changes
in
humans
rodents.
However,
the
chronic
neurotoxic
effects
of
arsenic
on
aquatic
animals
are
still
not
fully
understood.
This
study
aimed
investigate
exposure
adult
zebrafish
by
subjecting
3-month-old
three
different
sodium
arsenite
water
concentrations:
0
μg/L
(control
group),
50
μg/L,
500
over
period
30
days.
To
assess
risk
associated
with
environment,
behavior
analysis,
transmission
electron
microscopy
techniques,
quantitative
real-time
PCR
were
employed.
The
was
evaluated
using
six
distinct
tests:
mirror
biting
test,
shoaling
novel
tank
social
preference
recognition
T
maze.
Following
tests,
brains
dissected
collected
for
ultrastructural
examination
gene
expression
analysis.
results
revealed
that
led
significant
reduction
aggression,
cohesion,
ability,
cognition
learning,
memory
capacity
zebrafish.
Furthermore,
ultrastructure
genes
regulating
brain
adversely
affected
exposure.
Journal of Xenobiotics,
Journal Year:
2024,
Volume and Issue:
14(2), P. 537 - 553
Published: April 29, 2024
The
benzophenone
(BP)
family,
including
oxybenzone
(BP-3),
a
prevalent
sunscreen
ingredient
and
environmental
contaminant,
has
raised
concerns
since
the
year
2005.
This
study
investigated
toxicity
in
zebrafish
(Danio
rerio)
eleutheroembryos
brine
shrimp
(Artemia
salina)
nauplii,
focusing
on
LC50
developmental
impacts.
Zebrafish
embryos
(0.100–1.50
mg/L
BP-3,
96
h)
A.
salina
(0.100–5.00
48
were
tested
with
ultrasound-assisted
emulsified
liquid-phase
microextraction
(UA-ELPME)
used
for
tissue
analysis.
HPLC-DAD
determined
BP-3
concentrations
(highest:
0.74
±
0.13
mg/L).
Although
no
significant
embryo
mortality
or
hatching
changes
occurred,
effects
evident.
Lethal
(A.
at
24
h
=
3.19
2.02
mg/L;
D.
rerio
4.19
3.60
mg/L),
malformations
indicating
potential
teratogenic
effects.
displayed
intestinal
tract
alterations
exhibited
pericardial
edema
spinal
deformities.
These
findings
highlight
oxybenzone’s
risks,
posing
threats
to
species
ecosystem
health.
Brazilian Archives of Biology and Technology,
Journal Year:
2024,
Volume and Issue:
67
Published: Jan. 1, 2024
HIGHLIGHTS
Biomarkers
of
toxicity
in
zebrafish.
Toxicological
screening
with
the
embryonic,
larval,
and
adult
stages
Scientific
advancements
assessment
effects
environmental
contaminants.
