Long-term tralopyril exposure results in endocrinological and transgenerational toxicity: A two-generation study of marine medaka (Oryzias melastigma) DOI
Bin Liu, Ping Li,

Ren-Yan Du

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169344 - 169344

Published: Dec. 12, 2023

Language: Английский

Effects of parental exposure to amitriptyline on the survival, development, behavior, and gene expression in zebrafish offspring DOI
Anqi Liu, Chen Chen, Kun Chen

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169173 - 169173

Published: Dec. 6, 2023

Language: Английский

Citations

8
Reproductive damage and compensation of wild earthworm Metaphire californica from contaminated fields with long-term heavy metal exposure DOI
Caide Huang, Zhiqiang Shen,

Liang Li

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 311, P. 137027 - 137027

Published: Oct. 27, 2022

Language: Английский

Citations

12
Mechanistic Insights into 1,2-bis(2,4,6-tribromophenoxy)ethane-Induced Male Reproductive Toxicity in Zebrafish DOI

Na Zheng,

Xiaochen Wang,

Yindan Zhang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(19), P. 8251 - 8263

Published: May 2, 2024

The novel brominated flame retardant, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), has increasingly been detected in environmental and biota samples. However, limited information is available regarding its toxicity, especially at environmentally relevant concentrations. In the present study, adult male zebrafish were exposed to varying concentrations of BTBPE (0, 0.01, 0.1, 1, 10 μg/L) for 28 days. results demonstrated underperformance mating behavior reproductive success when paired with unexposed females. Additionally, a decline sperm quality was confirmed BTBPE-exposed zebrafish, characterized by decreased total motility, progressive increased morphological malformations. To elucidate underlying mechanism, an integrated proteomic phosphoproteomic analysis performed, revealing predominant impact on mitochondrial functions protein level universal response across different cellular compartments phosphorylation level. Ultrastructural damage, expression apoptosis-inducing factor, disordered respiratory chain involvement impairment testes. These findings not only provide valuable insights future evaluations potential risks posed similar chemicals but also underscore need further research into dysfunction health.

Language: Английский

Citations

2
Evaluation of the citalopram toxicity on early development of zebrafish: Morphological, physiological and biochemical responses DOI

Sundaram Mohanthi,

Jesudass Sutha,

Murugesh Gayathri

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 357, P. 124399 - 124399

Published: June 19, 2024

Language: Английский

Citations

2
Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa Ex Vivo , Male Zebrafish in Vivo , and GC-1 Cells in Vitro DOI Creative Commons
Lihua Yang,

Yindan Zhang,

Jianghuan Hua

et al.

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(11)

Published: Nov. 1, 2024

Legacy brominated flame retardants have been recognized as risky factors leading to declined sperm quality. The widespread utilization of decabromodiphenyl ethane (DBDPE) a replacement for ether has given rise considerable concern over its potential risks reproductive health. objectives were quickly determine whether DBDPE affects quality upon ex vivo exposure, reveal the outcomes and underlying molecular mechanisms using an in zebrafish model exposed DBDPE, validate impact on DNA damage energy metabolism balance vitro. Zebrafish spermatozoa treated with (0.01, 0.1, 1, 10μM) 3 h, motility fertilization ability normal eggs evaluated. Then adult male (0.1, 10, 100 nM) 2 months, their performance was examined. Four-dimensional label-free proteome phosphoproteome performed testes, findings validated by multiple indicators. Finally, mouse spermatogonial GC-1 cells 1μM) 72 examined, well production glycolysis oxidative phosphorylation. Ex exposure caused lower rates spermatozoa. In abnormal spermatogenesis testes. Integrated whole-proteome analysis revealed responses metabolic disorders A dosage window characterized higher mitochondrial membrane (MMP) combination unchanged reactive oxygen species apoptosis observed both testes cells. This study suggests that zebrafish, could impair spermatogenesis, mechanism be related reprogramming testicular germ https://doi.org/10.1289/EHP14426.

Language: Английский

Citations

2
Prenatal exposure to sertraline, associated or not with stress, can negatively program somatic and neurobehavioral development of female rats, and dysregulate reproductive function in adulthood DOI

Mayara Silva Moura,

Ana Flávia Quiarato Lozano,

Bruna Marques Tavares

et al.

Reproductive Toxicology, Journal Year: 2023, Volume and Issue: 116, P. 108336 - 108336

Published: Jan. 18, 2023

Language: Английский

Citations

3
Long-term tralopyril exposure results in endocrinological and transgenerational toxicity: A two-generation study of marine medaka (Oryzias melastigma) DOI
Bin Liu, Ping Li,

Ren-Yan Du

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169344 - 169344

Published: Dec. 12, 2023

Language: Английский

Citations

3