The Science of The Total Environment,
Journal Year:
2023,
Volume and Issue:
902, P. 166003 - 166003
Published: Aug. 6, 2023
The
accumulation
of
microplastics
(MPs)
in
the
environment
as
well
their
presence
foods
and
humans
highlight
urgent
need
for
studies
on
effects
these
particles
humans.
Polylactic
acid
(PLA)
is
most
widely
used
bioplastic
food
industry
medical
field.
Despite
its
biodegradability,
biocompatibility,
"Generally
Recognized
As
Safe"
(GRAS)
status,
recent
animal
model
have
shown
that
PLA
MPs
can
alter
intestinal
microbiota;
however,
to
date,
no
been
reported
possible
gut
health
consequences
intake
by
This
work
simulates
ingestion
a
realistic
daily
amount
pass
through
gastrointestinal
tract
combining
INFOGEST
method
simgi®
evaluate
human
colonic
microbiota
composition
(16S
rRNA
gene
sequencing
analysis)
metabolic
functionality
(lactic
short-chain
fatty
acids
(SCFA)
production).
Although
did
not
clearly
microbial
community
homeostasis,
increased
Bifidobacterium
levels
tended
increase
millimetric
particles.
Furthermore,
shifts
detected
at
functional
level
suggest
an
alteration
metabolism,
biotransformation
community.
Raman
spectroscopy
field
emission
scanning
electron
microscopy
(FESEM)
characterization
revealed
morphological
changes
after
gastric
phase
digestion,
adhesion
organic
matter
biofilm,
with
surface
biodegradation,
phases.
With
this
evidence
emerging
use
bioplastics,
understanding
impact
potential
biodegradation
digestion
merits
critical
investigation.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(4), P. 1832 - 1841
Published: Jan. 17, 2024
The
massive
production
of
plastics
causes
the
ubiquitous
existence
microplastics
(MPs)
in
biota,
therefore,
posing
exposure
risks
and
potential
health
concerns
to
human
beings.
However,
exact
mechanisms
MPs-induced
toxicities
abnormalities
are
largely
unknown.
In
this
study,
we
developed
a
mouse
model
gavage
polystyrene
(PS
MPs)
for
30
days.
We
found
that
PS
MPs
can
damage
intestinal
barrier,
accumulate
liver
tissue,
cause
injury.
intestine
both
highly
associated
with
bile
acid
(BA)
metabolism.
Indeed,
dysregulate
BA
synthesis
efflux-related
gene
expression
liver,
causing
cholestasis.
Tandemly,
alter
ratio
primary
secondary
feces
by
affecting
composition
flora.
At
last,
mice's
fecal
profile,
which
affects
normal
Taken
together,
present
study
provides
robust
data
on
mechanism
toxicity
disturbance
metabolism
via
4-step
gut-liver
loop.
Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
241, P. 113809 - 113809
Published: July 4, 2022
Microplastics
(MPs)
are
a
new
kind
of
environmental
pollutant
that
has
attracted
extensive
attention
in
recent
years.
MPs
can
be
ingested
by
multiple
organisms
and
mainly
accumulate
the
intestine.
However,
there
is
still
little
known
about
toxic
effects
on
humans.
Here,
we
chose
male
adult
mice
as
research
model,
which
were
exposed
to
2
µm
polyvinyl
chloride
(PVC)
at
concentration
100
mg/kg
for
consecutive
60
days,
study
toxicity
PVC-MPs.
The
changes
gut
histology,
enzymatic
biomarkers,
intestinal
microbiome,
metabolomic
responses
monitored
mice.
results
displayed
PVC-MPs
reduced
mucus
secretion
increased
permeability.
Moreover,
exposure
decreased
mRNA
expression
levels
colonic
secretion-related
genes,
indicating
dysfunction
after
With
regard
microbiota,
high
throughput
sequencing
full-length
16S
rRNA
gene
indicated
15
17
kinds
microbes
changed
markedly
genus
species
level,
respectively.
Furthermore,
marked
alterations
microbiome
fecal
metabolic
profiles
observed,
most
related
injury
barrier
dysfunction.
These
show
leads
composition
metabolome
profiles,
thus
health
risk
animals
needs
more
concern.
This
helps
provide
idea
