Environmental Health,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Nov. 7, 2023
Abstract
Perfluoroalkyl
and
polyfluoroalkyl
substances
(PFASs)
may
have
a
role
in
impaired
health.
However,
the
data
on
association
between
PFASs
Systemic
lupus
erythematosus
(SLE)
been
limited.
We
designed
population-based
case–control
study
China
evaluated
association.
100
normal
persons
(Control)
SLE
patients
(Case)
were
obtained
from
113
controls
125
cases
according
to
matching
conditions.
Serum
samples
collected
by
venipuncture
for
UHPLC-MRM-MS
Analysis
obtain
concentration
of
five
participants.
Demographic
characterization
description
was
performed
two
groups
participants,
distribution
described
compared,
then
divided
into
three
tiers
(<
50th,
50th
~
75th,
>
75th)
subsequent
analysis.
Conditional
logistic
regression
models
utilized
calculate
odds
ratios
(ORs)
95%
CIs
SLE.
Relationship
changes
risk
assessed
restricted
cubic
spline.
As
highest
serum
levels
tested
this
population,
perfluoroundecanoic
acid
(PFUnA)
quartile
had
2.78-fold
(95%CI:
1.270,
6.10)
compared
with
lowest
PFUnA
exposure,
other
types
also
showed
high
as
well
mixture.
Additionally,
exposure
exist
dose–response
relationship
(ptrend
<
0.05).
This
remained
be
found
after
adjusting
covariates
model
1
(adjustment
BMI)
2(adjustment
BMI,
smoking,
drinking,
hypertension
leukocyte).
The
spline
illustrated
gradual
increase
possible
increasing
components
levels.
Our
firstly
revealed
that
are
factors
exposures
associated
dose
−
response
manner.
Evidence
larger
more
adequately
powered
cohort
studies
is
needed
confirm
our
results.
Abstract
Background
Exposure
to
heavy
metals,
particularly
lead
and
mercury,
has
been
identified
as
a
significant
risk
factor
for
renal
dysfunction,
often
through
mechanisms
involving
oxidative
stress.
Despite
extensive
research,
the
specific
role
of
serum
α-klotho
in
modulating
effects
these
metals
on
kidney
function
remains
unclear.
This
study
aims
elucidate
relationship
between
levels
lead,
function,
investigate
stress's
potential
modulatory
effects,
explore
mediating
this
context
among
US
adults,
derived
from
National
Health
Nutrition
Examination
Survey
(NHANES)
data
spanning
2007
2016.
Methods
In
cross-sectional
analysis
11,032
adults
aged
40
79
years
NHANES,
we
measured
mercury
via
inductively
coupled
plasma
mass
spectrometry
using
enzyme-linked
immunosorbent
assay
(ELISA).
Kidney
was
evaluated
creatinine-based
estimated
glomerular
filtration
rate
(eGFR).
Multivariable
linear
regression
models
were
applied
correlations
metal
concentrations,
α-klotho,
eGFR.
Additionally,
mediation
model
employed
determine
exposure
function.
Results
Our
findings
indicate
association
reduced
eGFR,
suggesting
impaired
with
increased
exposure.
Mediation
revealed
that
mediated
6.10–9.75%
effect
highlighting
its
pathway
Subgroup
further
specified
significantly
mediates
women
individuals
40–69,
whereas
did
not
show
distinct
patterns
across
gender
age
groups.
Conclusions
The
demonstrates
are
negatively
correlated
playing
association.
These
underscore
importance
considering
health,
offering
new
insights
into
preventive
therapeutic
impairment.
Further
research
is
warranted
clinical
applications
targeting
mitigating
adverse
kidneys.
