Chemical Mixtures and Multiple Stressors: Same but Different?

Environmental Toxicology and Chemistry, Journal Year: 2023, Volume and Issue: 42(9), P. 1915 - 1936

Published: April 10, 2023

Ecosystems are strongly influenced by multiple anthropogenic stressors, including a wide range of chemicals and their mixtures. Studies on the effects stressors have largely focussed nonchemical whereas studies chemical mixtures ignored other stressors. However, both research areas face similar challenges require tools methods to predict joint or frameworks integrate missing. We provide an overview paradigms, tools, commonly used in stressor mixture discuss potential domains cross-fertilization challenges. First, we compare general paradigms ecotoxicology (applied) ecology explain historical divide. Subsequently, approaches for identification interactions, characterization, designing experiments. suggest that too focused interactions would benefit from integration regarding null model selection. Stressor characterization is typically more costly While comprehensive classification systems at suborganismal level been developed, recent account environmental context. Both suffer rather simplified experimental designs focus only limited number chemicals, treatments. concepts can guide realistic capturing spatiotemporal dynamics. process-based data-driven models particularly promising tackle challenge prediction (meta-)communities (meta-)food webs. propose framework assessment Environ Toxicol Chem 2023;42:1915-1936. © 2023 The Authors. Environmental Toxicology Chemistry published Wiley Periodicals LLC behalf SETAC.

Language: Английский

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Predicting the Metal Mixture Toxicity with a Toxicokinetic–Toxicodynamic Model Considering the Time-Dependent Adverse Outcome Pathways

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(8), P. 3714 - 3725

Published: Feb. 13, 2024

Chemicals mainly exist in ecosystems as mixtures, and understanding predicting their effects are major challenges ecotoxicology. While the adverse outcome pathway (AOP) toxicokinetic–toxicodynamic (TK–TD) models show promise mechanistic approaches chemical risk assessment, there is still a lack of methodology to incorporate AOP into TK–TD model. Here, we describe novel approach that integrates predict mixture toxicity using metal mixtures (specifically Cd–Cu) case study. We preliminarily constructed an through temporal transcriptome analysis together with confirmatory bioassays. The revealed prolonged exposure time activated more key events outcomes, indicating different modes action over time. selected potential event proxy for damage used it measurable parameter replace theoretical (scaled damage) This refined model, which connects molecular responses organism effectively predicts Cd–Cu can be extended other even multicomponent mixtures. Overall, our results contribute better provide insights integrating improve assessment

Language: Английский

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C–S–H-PCE nanoparticles and anionic surfactants as nucleation agent in cement based materials: Focus on the antagonism

Cement and Concrete Composites, Journal Year: 2024, Volume and Issue: 152, P. 105644 - 105644

Published: June 26, 2024

Language: Английский

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Enzymatic activity and gene expression changes in the earthworms induced by co-exposure to beta-cypermethrin and triadimefon

Ecotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

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Combined Toxicity of Chemicals: Final Thoughts and Concluding Remarks

Published: Jan. 14, 2025

Language: Английский

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Novel Quantitative Structure–Activity Relationship Tox21 Techniques for Combined Toxicity Prediction

Published: Jan. 14, 2025

Humans and animals are exposed to mixtures of various environmental pollution; however, there is limited toxicity data for chemical mixtures, the traditional methodologies evaluating effects including concentration addition (CA) independent action (IA) models have been increasingly challenged replaced. The computational approaches quantitative structure–activity/property/toxicity relationship (QSAR/QSPR/QSTR) already proven efficient alternatives assessing mixtures. In this chapter, QSAR predicting endocrine-disrupting activities acute toxicities, as well based on machine-learning method, biomolecular interaction networks, toxicokinetic–toxicodynamic studies, high-throughput transcriptomics approach, geospatial modeling approach reviewed. prediction needs be integrated a comprehensive systems-level analysis identify their effect by integrating bioactivity bioactivity, targets pathways, gene expression, protein interactions, localized exposure data, which will help provide solid foundation analyses.

Language: Английский

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Studying interaction effects on toxicokinetics in zebrafish combining experimental and modelling approaches

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 965, P. 178663 - 178663

Published: Jan. 31, 2025

Humans and wildlife are exposed to a complex mixture of anthropogenic chemicals which only few have been subjected regulations. Chemical risk assessment is currently based on evaluating single chemicals, costly, time-consuming, neglect toxicokinetic toxicodynamic effects. This study focused interaction effects the absorption, distribution, metabolism excretion (ADME) processes selected representing potential modulators these processes. Adult female zebrafish (Danio rerio) were 11 bioconcentration factors (BCFs) tissue level determined for 9 them: bisphenol A (BPA), AF (BPAF), Z (BPZ), triclosan, tribromophenol, pentachlorophenol, heptafluorobutyric acid (PFBA), perfluorobutanesulfonic (PFBS), perfluorooctanesulfonic (PFOS). Comparison BCFs bisphenols obtained from chemical exposure experiments versus current revealed no statistically significant differences (p > 0.05), implying kinetics at investigated concentrations. The same conclusion was reached using two physiologically kinetic (PBK) models, developed individual per- polyfluoroalkyl substances (PFAS), showing good model fit BPA, BPZ, BPAF, PFOS. To simulate scenarios where may occur through competitive protein binding in blood, new PBK developed. Simulations dosed with BPA individually, combined varying levels PFOS, showed that serum proteins alter when PFOS exceeded 1 μg/L. indicates acting concert could perturb ADME but higher or mixtures.

Language: Английский

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Fungicides in English Rivers: Widening the Understanding of the Presence, Co-Occurrence and Implications for Risk Assessment

Environments, Journal Year: 2025, Volume and Issue: 12(2), P. 45 - 45

Published: Feb. 3, 2025

Fungicides are commonly found in freshwater; however, the understanding of their wider presence, co-occurrence, and potential risk remains limited. This study examined English national datasets to highlight knowledge gaps identify improvements monitoring assessment. The analysis that at least one fungicide was present 91% samples collected from rivers over a 5-year period, with four fungicides detected rates exceeding 50%. Co-occurrence occurs widely, up nine different within same sample most frequently, raising concerns for synergistic interactions. semi-quantitative nature much available data precludes clear determination detrimental effects on aquatic biota. Fully quantitative is required, ecotoxicity-based water quality standards need be agreed upon. monthly sampling regime reflected will infrequently capture high flow events so unlikely fully represent transported via rainfall-driven processes. Several information exist, including posed by sewage sludge applied land extent which terrestrial environments contribute antifungal resistance. Improvements spatial temporal use needed.

Language: Английский

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Degradation and ecotoxicity of favipiravir and oseltamivir in the presence of microplastics during ozonation and catalytic ozonation of synthetic municipal wastewater effluents

Journal of Chemical Technology & Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Background Favipiravir (FAV) and oseltamivir (OSE) are antiviral agents developed against influenza they were repurposed SARS‐CoV‐2 during the COVID‐19 pandemic. This study evaluated potential of ozonation catalytic as tertiary treatment approaches for removing FAV OSE from municipal wastewaters, both in presence absence microplastics (MPs), while comparing ecotoxicity untreated treated secondary effluents to predict ecotoxicological effects these technologies wastewater treatment. Results At an initial concentration 50 μg L −1 , at pH 7 with a specific ozone dose 0.6 mg O 3 (mg DOC) yielded removals 84 64%, respectively, catalyst or MPs decreased degradation rate by 30–40%. Raising 10 had minimal impact on abatement, but improved reduction 21%. Acute toxicity tests using Vibrio fischeri demonstrated that simultaneous analytes led accumulation transformation products (TPs) OSE, their combined effect almost equal original compounds. Reproduction indicated TPs drugs generated less toxic Enchytraeus crypticus than parent chemicals. Conclusion Ozonation proved be viable option upgrading existing facilities, serving complementary minimize release antivirals reduce inhibitory earthworm reproduction, thereby enhancing reuse irrigation. © 2025 The Author(s). Journal Chemical Technology Biotechnology published John Wiley & Sons Ltd behalf Society Industry (SCI).

Language: Английский

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Co-contaminant risks in water reuse and biosolids application for agriculture

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126219 - 126219

Published: April 1, 2025

Language: Английский

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