Trophic transfer of carbon-14 from algae to zebrafish lead its blending in biomolecules and dysregulating metabolism via isotope effect DOI Creative Commons
Shipeng Dong,

Renquan Deng,

Hang Zeng

et al.

National Science Review, Journal Year: 2024, Volume and Issue: 12(1)

Published: Sept. 29, 2024

ABSTRACT Carbon-14 (C-14) has been a major contributor to the human radioactive exposure dose, as it is released into environment from nuclear industry in larger quantities compared other radionuclides. This most abundant nuclide enters biosphere organically bound C-14 (OBC-14), posing potential threat public health. Yet, remains unknown how this relatively low radiotoxic induces health risks via chemical effects, such isotope effect. By establishing trophic transfer model involving algae (Scenedesmus obliquus), daphnia (Daphnia magna) and zebrafish (Danio rerio), we demonstrate that rapid incorporation transformation of inorganic by OBC-14 facilitates blending biomolecules zebrafish. We find internalized persistently retained brain zebrafish, affecting DNA methylation causing alterations neuropathology. Global tracing metabolomics with further reveals involvement various critical metabolic pathways, including one-carbon metabolism nucleotide metabolism. thus characterize kinetic effects for 12C/14C key reactions these pathways through experiments density functional theory computations, showing isotopic substitution carbon biochemicals regulates disrupting reaction ratios effects. Our results suggest discharged can be biotransformed impact providing new insights understanding risk C-14, which traditionally considered nuclide.

Language: Английский

Realistic concentrations of Bisphenol-A trigger a neurotoxic response in the brain of zebrafish: Oxidative stress, behavioral impairment, acetylcholinesterase inhibition, and gene expression disruption DOI
Gerardo Heredia-García, Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez‐Oliván

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 330, P. 138729 - 138729

Published: April 18, 2023

Language: Английский

Citations

15
A Novel Method for the Assessment of Feeding Rate as a Phenotypic Endpoint for the Impact of Pollutants in Daphnids DOI Creative Commons
Emma Rowan, A.Y.T. Leung, Konstantinos Grintzalis

et al.

Environmental Toxicology and Chemistry, Journal Year: 2024, Volume and Issue: 43(10), P. 2211 - 2221

Published: July 26, 2024

Traditional approaches for monitoring aquatic pollution primarily rely on chemical analysis and the detection of pollutants in aqueous environments. However, these methods lack realism mechanistic insight and, thus, are increasingly supported by effect-based methods, which offer sensitive endpoints. In this context, daphnids, a freshwater species used extensively molecular ecotoxicology, fast noninvasive to assess impact pollutants. Among phenotypic endpoints used, feeding rate is highly approach because it provides evidence physiological alterations even sublethal concentrations. there has been no standardized method measuring several follow different protocols. There diversity among tests employing large volumes, extensive incubation times, high animal densities, turn utilize measurements algae via fluorescence, radiolabeling, or counting ingested cells. These challenging laborious sometimes require cumbersome instrumentation. present study, we optimized conditions miniaturized fast, sensitive, high-throughput assay based ingestion fluorescent microparticles. The protocol was neonates relation concentration microplastic number animals increase reproducibility. Daphnids, following exposures nonlethal concentrations, were incubated with microplastics; as filter feeders, they ingest new revealed differences physiology daphnids concentrations below toxicity limits range modes action, thus proving be more endpoint assessment. Environ Toxicol Chem 2024;43:2211-2221. © 2024 Author(s). Environmental Toxicology Chemistry published Wiley Periodicals LLC behalf SETAC.

Language: Английский

Citations

5
Influence of sucralose, acesulfame-k, and their mixture on brain's fish: A study of behavior, oxidative damage, and acetylcholinesterase activity in Danio rerio DOI

Karla Colín-García,

Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez‐Oliván

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 340, P. 139928 - 139928

Published: Aug. 23, 2023

Language: Английский

Citations

11
Assessing the impact of COVID-19 era drug combinations on hepatic functionality: A thorough investigation in adult Danio rerio DOI
Diana Belén Onofre-Camarena, Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez‐Oliván

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 349, P. 123997 - 123997

Published: April 16, 2024

Language: Английский

Citations

4
Transcriptome-Guided Characterization of the Environmental Toxicity of Metformin: Disruption of Energy Homeostasis and Inhibition of Embryonic Development of Zebrafish at Environmentally Relevant Concentrations DOI
Ziyu Zhang, Haochun Shi, Kun Zhang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Metformin has been widely detected in aquatic ecosystems, yet the knowledge of its impact on organisms, particularly at environmentally relevant concentrations, remains limited. In present study, we characterized developmental toxicity metformin zebrafish, utilizing a transcriptome-guided toxicological assessment framework. Transcriptomic analysis conducted concentrations within μg/L range revealed significant disruptions biological processes associated with nucleotide, hydrocarbon, and amino acid metabolism, suggesting disturbance energy homeostasis. This observation was corroborated by energy-targeted metabolomic analysis, wherein considerable number metabolites involved purine pyrimidine citrate cycle displayed alterations. Notably, most intermediates such as acetyl-CoA exhibited remarkable decreases. Additionally, our study identified impediments zebrafish embryonic development, including decreased yolk extension progress, spontaneous contraction body length, increased sac area yolk/while lipid content ratio, low 0.12 μg/L. Furthermore, disruption homeostasis observed to persist into adulthood even after prolonged recovery period. The findings highlighted disruptive effects development teleost thereby prompting reevaluation environmental risk nontarget organisms.

Language: Английский

Citations

4
Detrimental impact of photo-Fenton treated COVID-19 drugs on liver function: A thorough investigation in Danio rerio DOI
Gustavo Axel Elizalde-Velázquez,

Claudia Victoria,

Deysi Amado-Piña

et al.

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 381, P. 125182 - 125182

Published: April 10, 2025

Language: Английский

Citations

0
The elevated toxicity of the biodegradation product (guanylurea) from metformin and the antagonistic pattern recognition of combined toxicity: Insight from the pharmaceutical risk assessment and the simulated wastewater treatment DOI
Fan Gao, Hao Wen, Sen Feng

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 892, P. 164747 - 164747

Published: June 7, 2023

Language: Английский

Citations

10
Temperature- and chemical-induced neurotoxicity in zebrafish DOI Creative Commons
Mattia Toni, Chiara Arena,

Carla Cioni

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 3, 2023

Throughout their lives, humans encounter a plethora of substances capable inducing neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests when exposure to these chemicals disrupts the normal functioning nervous system, some agents have been linked neurodegenerative pathologies such as Parkinson's Alzheimer's disease. The growing concern surrounding impacts both naturally occurring man-made toxic necessitates identification animal models for rapid testing across wide spectrum concentrations, utilization tools detecting system alterations spanning from molecular level up behavioural one. Zebrafish (Danio rerio) is gaining prominence in field neuroscience due its versatility. possibility analysing all developmental stages (embryo, larva adult), applying most common "omics" approaches (transcriptomics, proteomics, lipidomics, etc.) conducting range tests makes zebrafish an excellent model neurotoxicity studies. This review delves into main experimental adopted markers analysed studies zebrafish, showing that phenomena can be triggered not only by chemical but also fluctuations temperature. findings presented here serve valuable resource study define new scenarios ecotoxicology suggesting temperature synergistically compound effects substances, intensifying detrimental impact on fish populations.

Language: Английский

Citations

10
Effects of Exposure to Bauxite Residue Leachates from Short-Term Revegetation on Oxidative Stress and DNA Damage in Zebrafish (Danio rerio) DOI

Zuyan Wan,

Yi Lou, Yulu Chen

et al.

Water Air & Soil Pollution, Journal Year: 2025, Volume and Issue: 236(5)

Published: April 8, 2025

Language: Английский

Citations

0
Polystyrene microplastics mitigate the embryotoxic damage of metformin and guanylurea in Danio rerio DOI
Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez‐Oliván, Sandra García-Medina

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 852, P. 158503 - 158503

Published: Sept. 2, 2022

Language: Английский

Citations

15