Ecotoxicological interactions between triclosan and 17α-ethinylestradiol: chronic assessment in Ceriodaphnia dubia and mixture effects

Caderno Pedagógico, Journal Year: 2025, Volume and Issue: 22(4), P. e14451 - e14451

Published: Feb. 28, 2025

The chronic effects of triclosan (TCS) and 17α-ethinylestradiol (EE2) were assessed individually in Ceriodaphnia dubia. joint effect dubia was determined using the concentration addition (CA) independent action (IA) mathematical models. synergy antagonism resulting from binary mixtures these compounds, deviations related to dose-level dose-ratio dependence investigated. Both compounds are endocrine disruptors, present hygiene pharmaceutical products, potentially causing environmental wildlife issues. results bioassay with demonstrated that TCS an EC50 (median effective concentration) = 93 ± 1.41µg L-1 more toxic than EE2 589 2.12 µg for microcrustaceans. CA model better predicted mixture toxicity. revealed interactions between mainly showing synergism, but also dose level synergism at low levels high levels. identified this study underscore significance enhancing chemical screenings samples toxicity data, especially when dealing combinations whose not well understood.

Language: Английский

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Effects of the fatty acid synthase inhibitors triclosan and lapatinib on dengue virus and Zika virus infection

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 28, 2025

Fatty acid synthase (FASN) has been shown to be critical in the replication of several viruses genus Orthoflavivirus. In this study role two inhibitors FASN that work through different mechanisms were investigated dengue virus (DENV) and Zika (ZIKV) infections. Triclosan is a inhibitor targets enol reductase domain FASN, while lapatinib exerts an effect on acting HER2, upstream regulator FASN. After determining cytotoxicity, comprehensive analysis these drugs DENV 2 ZIKV infection was undertaken. The results showed triclosan had moderate antiviral activity against both (EC50 = 10.21 µM; Selective index (SI) 3.99) ( EC50 22.84 SI 5.49). Lapatinib reasonable 4.9 26.09), but computer modeling suggested potential directly by binding NS5. result better fit with NS5 than NS5, confirmed as for towards µM calculated 37.92. are consistent other studies use target domains suggesting simply targeting enzymatic insufficient therapeutic drug development, lapatinib, or similar molecules may have real potential.

Language: Английский

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Metabolomics reveals increased toxicity in earthworms (Eisenia fetida) of the transformation product methyl-triclosan

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118128 - 118128

Published: April 1, 2025

The effects of triclosan (TCS) and its transformation product methyl-triclosan (MTCS) on the earthworm Eisenia fetida were investigated using Gas chromatography-mass spectrometry (GC-MS) metabolomics. Earthworms exposed to 0, 0.25, 1, 4, 16, 64 µg g-1 either TCS or MTCS for 14 days in commercial worm bedding. Only exposure caused any metabolites targeted this study. Succinic acid was elevated relative control at concentrations ≥ 0.25 glucose 1 g-1. had greatest separation from Principal Components Analysis (PCA), while largest Discriminant (DA). Essential amino acids valine, leucine, serine, phenylalanine large, standardized coefficients PCA DA reflecting their contribution separation, suggesting that essential homeostasis perturbed by MTCS. Malic acid, succinic margaric highly correlated (p < 0.01) with Canonical PC 2, maltose 2 7, indicating a strong relationship between these multivariate expressed canonical variables. Disruption succinate metabolism membrane destabilization mitochondria hypothesized as possible mode action

Language: Английский

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Isatin-linked Pyrazole K1 derivative alter the phosphatidylinositol-3-kinase pathway by enhancing the metabolic function and folliculogenesis in the triclosan-induced PCOS-like condition in zebrafish model

Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 104695 - 104695

Published: April 1, 2025

Language: Английский

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Acute/chronic triclosan exposure induces downregulation of m6A-RNA methylation modification via mettl3 suppression and elicits developmental and immune toxicity to zebrafish

Chemosphere, Journal Year: 2024, Volume and Issue: 352, P. 141395 - 141395

Published: Feb. 9, 2024

Language: Английский

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Neurotoxic effects of triclosan in adolescent mice: Pyruvate kinase M2 dimer regulated signal transducer and activator of transcription 3 phosphorylation mediated microglia activation and neuroinflammation

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 942, P. 173739 - 173739

Published: June 4, 2024

Language: Английский

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Co-Existing Nanoplastics Further Exacerbates the Effects of Triclosan on the Physiological Functions of Human Serum Albumin

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 112 - 112

Published: Jan. 16, 2025

The potential health risks posed by the coexistence of nanoplastics (NPs) and triclosan (TCS) have garnered significant attention. However, effects underlying mechanisms NPs TCS on key functional proteins at molecular level remain poorly understood. This study reports effect polystyrene (PSNPs) binding to human serum albumin (HSA) using multispectral methods simulation systems. experimental results show that significantly inhibits HSA esterase activity, with exacerbating inhibition in presence PSNPs, which is attributed alteration conformation microenvironment amino acid residues induced PSNPs. Molecular docking site marker competitive studies indicate predominantly binds I subdomain Sudlow II PSNPs does not affect sites. Spectra analyses quenching mechanism between belongs static type change fluorescence type. conformational alterations are further enhanced indicating enhance making more accessible provides valuable information about toxicity case co-exposure.

Language: Английский

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Elevated Reproductive Risk and Toxicity of Triclosan in Urban Freshwater Environments after the COVID- 19 Pandemic

Water Air & Soil Pollution, Journal Year: 2025, Volume and Issue: 236(5)

Published: April 8, 2025

Language: Английский

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The intestinal toxicity mechanisms of Triclosan and Triclocarban and their possible clinical nutritional intervention mechanisms

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126396 - 126396

Published: May 1, 2025

Language: Английский

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A Short Review of the Toxicity of Dentifrices—Zebrafish Model as a Useful Tool in Ecotoxicological Studies

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14339 - 14339

Published: Sept. 20, 2023

This review aims to summarize the literature data regarding effects of different toothpaste compounds in zebrafish model. Danio rerio provides an insight into mechanisms ecotoxicity chemicals as well assessment their fate environment determine long-term environmental impact. The regular use adequate with safe active ingredients possessing anti-bacterial, anti-inflammatory, anti-oxidant, and regenerative properties is one most effective strategies for oral healthcare. In addition water, a typical consists variety components, among which three are predominant importance, i.e., abrasive substances, fluoride, detergents. These provide healthy teeth, but impact on living organisms often not well-known. Each them can influence higher level organization: subcellular, cellular, tissue, organ, individual, population. Therefore, it very important that chemical detected before released minimize damage. An part risk estimation compound. model has unique advantages research been used study vertebrate developmental biology. Among others, this include its external, visually accessible development, allows providing many experimental manipulations. significant genetic similarity other vertebrates. Nevertheless, translating findings from studies human requires careful consideration these differences.

Language: Английский

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