A comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 30, 2024

Smog is a form of extreme air pollution which comprises gases such as ozone, sulfur dioxide, nitrogen and carbon oxides, solid particles including particulate matter (PM 2.5 PM 10 ). Different types smog include acidic, photochemical, Polish. its constituents are hazardaous to human, animals, plants. leads plethora morbidities cancer, endocrine disruption, respiratory cardiovascular disorders. components alter the activity various hormones thyroid, pituitary, gonads adrenal by altering regulatory genes, oxidation status hypothalamus-pituitary axis. Furthermore, these toxicants responsible for development metabolic disorders, teratogenicity, insulin resistance, infertility, carcinogenicity glands. Avoiding fossil fuel, using renewable sources energy, limiting gaseous discharge from industries can be helpful avoid disruption other toxicities smog. This review focuses on toxic implications system, their toxicodynamics preventive measures hazardous health effects.

Language: Английский

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China's anthropogenic N2O emissions with analysis of economic costs and social benefits from reductions in 2022

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 353, P. 120234 - 120234

Published: Feb. 1, 2024

Language: Английский

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The relationship between cooking fuel use and sex hormone levels: A cross-sectional study and Mendelian randomization study

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170621 - 170621

Published: Feb. 3, 2024

Language: Английский

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Association between Volatile Organic Compound Exposure and Sex Hormones in Adolescents: The Mediating Role of Serum Albumin

Toxics, Journal Year: 2024, Volume and Issue: 12(6), P. 438 - 438

Published: June 18, 2024

The associations between VOCs and sex hormones in adolescents remain unclear, the role of serum albumin these deserves to be explored. We conducted cross-sectional analyses using generalized linear models (GLMs), weighted quantile sum (WQS) regression, mediation analysis, based on data from 584 National Health Nutrition Examination Survey (NHANES). GLM revealed that seven kinds mVOCs potentially affected hormone levels. According WQS regression results, 2-aminothiazoline-4-carboxylic acid (ATCA) was major contributor significant mixed mVOC exposure with testosterone, estradiol, free androgen index males; N-acetyl-S-(N-methylcarbamoyl)-L-cysteine (AMCC) hormone-binding globulin N-acetyl-S-(benzyl)-L-cysteine (BMA) ratio testosterone estradiol females. Moreover, could mediate up 9.2% hormones. Our findings provide a reference for studies mechanisms underlying effects emphasize necessity reducing ATCA, AMCC, BMA, their parent compounds.

Language: Английский

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The Chemical Exposome on Ovarian Aging in Adult Women: a Narrative Review

Current Pollution Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 19, 2025

Language: Английский

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Fine particulate matter components and reproductive hormones in female adults: A 15-year longitudinal cohort study

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 266, P. 114562 - 114562

Published: March 18, 2025

Few cohort studies have evaluated the long-term impacts of ambient fine particulate matter (PM2.5) and its components on reproductive hormone levels in female adults. We conducted a 15-year retrospective study Taiwan between 2003 2017. The two-year average concentrations PM2.5 components, including sulfate (SO42-), nitrate (NO3-), ammonium (NH4+), organic (OM), black carbon (BC), were assessed at each participant's addresses. Linear mixed models used to examine associations with hormones, follicle-stimulating (FSH), luteinizing (LH), testosterone (T), estradiol (E2), prolactin (PRL). Stratified analyses identify vulnerable populations. 17,152 adults included. Each interquartile range (IQR: 3.545 μg/m3) increase was associated 0.585 mIU/mL [95% confidence interval (CI): 0.190-0.980] FSH levels. Among five PM2.5, BC had strongest positive association [each IQR (0.272 0.863 (95% CI: 0.476-1.250) levels], followed by OM, SO42-, NH4+. Similar found for LH, 0.483 0.225-0.742) 0.684 0.431-0.938) LH per BC, respectively. pollutants marginally decreased E2 increased PRL Non-linear FSH, E2, observed. These also positively T among young Post-menopausal women more susceptible chronic components. Our highlighted adverse exposure hormonal homeostasis, revealing biological mechanism air pollution-reproductive health females. Implementing stringent control pollution can benefit adults, even moderately polluted regions.

Language: Английский

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Long-term effect of fine particulate matter constituents on reproductive hormones homeostasis in women attending assisted reproductive technologies: A population-based longitudinal study

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116915 - 116915

Published: Aug. 22, 2024

Fine particulate matter (PM

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Sulfur dioxide increases testosterone biosynthesis by activating ERK1/2 pathway and disrupting autophagy in Leydig cells

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 486, P. 137001 - 137001

Published: Dec. 26, 2024

Language: Английский

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The prevalent trajectory of early menopause associated with PM2.5 exposure across 1956–2018 extrapolated from LightGBM algorithm

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117107 - 117107

Published: Sept. 26, 2024

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Association of specific PM2.5 chemical constituents and ozone exposure with pregnancy outcomes in women undergoing assisted reproductive technology treatment in central China

International Journal of Hygiene and Environmental Health, Journal Year: 2024, Volume and Issue: 263, P. 114474 - 114474

Published: Oct. 7, 2024

Language: Английский

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