DEHP impairs the oxidative stress response and disrupts trace element and mineral metabolism within the mitochondria of detoxification organs DOI
Duygu Aydemir, Gözde Karabulut, Nurhayat Barlas

et al.

Toxicology and Industrial Health, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Di(2-ethylhexyl) phthalate (DEHP), a widely utilized plasticizer in various consumer products, is classified as an endocrine disruptor and has been implicated numerous adverse health effects, including oxidative stress, inflammation, metabolic disturbances. Despite the growing body of literature addressing systemic effects DEHP, specific influence DEHP-induced stress on mitochondrial function within detoxification organs, particularly liver kidneys, remains largely unexplored. This study evaluated DEHP exposure (0, 100, 200, 400 mg/kg/day) trace elements, mineral metabolism associated with signaling pathways kidneys rats. Altered status was indicated by impaired glucose 6-phosphate dehydrogenase (G6PD), 6-phosphoglucerate (6-PGD), glutathione reductase (GR), s-transferase (GST), peroxidase (GPx) activities, along significant disruptions essential minerals Na, Mg, Cu, Zn, Fe. Key pathways, such NF-κB, Akt, STAT3, CREB, glucose, tissue homeostasis, displayed dose-dependent responses to indicating complex regulatory mechanisms. represents first comprehensive investigation into dysfunction, highlighting its metabolism, element cellular organs. These findings provide novel insights mechanisms underlying toxicity underscores need for further research implications human health.

Language: Английский

Dietary habit helps improve people’s adaptability to hot climates: a case study of hotpot in Chongqing, China DOI
Hongqiao Qin, Jianghua Chen, Jiaqi Niu

et al.

International Journal of Biometeorology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Language: Английский

Citations

0
Metabolic disrupting chemicals in the intestine: the need for biologically relevant models DOI Creative Commons
Chedi Erradhouani, Sylvie Bortoli, Sélim Aı̈t-Aı̈ssa

et al.

FEBS Open Bio, Journal Year: 2024, Volume and Issue: 14(9), P. 1397 - 1419

Published: Sept. 1, 2024

Although the concept of endocrine disruptors first appeared almost 30 years ago, relatively recent involvement these substances in etiology metabolic pathologies (obesity, diabetes, hepatic steatosis, etc.) has given rise to Metabolic Disrupting Chemicals (MDCs). Organs such as liver and adipose tissue have been well studied context disruption by substances. The intestine, however, unexplored despite its close link with organs. In vivo models are useful for study effects MDCs intestine and, addition, allow investigations into interactions rest organism. latter respect, zebrafish is an animal model which used increasingly characterization use a assessing on will, no doubt, expand. This review aims highlight importance metabolism present relevant alternative investigating effect pollutants focusing, particular, cytochrome P450 3A (CYP3A), one major molecular players endogenous gut.

Language: Английский

Citations

3
Cordyceps polysaccharide improves polycystic ovary syndrome by inhibiting gut-derived LPS/TLR4 pathway to attenuates insulin resistance DOI
Huiwen Zhang, Ziwen He,

Yigong Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135844 - 135844

Published: Sept. 1, 2024

Language: Английский

Citations

3
The endocrine disruptor effect of metal nanoparticles mainly depends on their capacity to release metal ions DOI Creative Commons

Peggy Charbonnier,

Pierre‐Henri Jouneau, Aurélien Deniaud

et al.

Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(7), P. 3192 - 3201

Published: Jan. 1, 2024

This study compares the impact of different types metal nanoparticles on major endocrine pathways. It shows that ions releasing ones such as silver inhibit Zn-finger dependent pathways, while rock solid do not.

Language: Английский

Citations

2
Kidney transplantation and gut microbiota DOI Creative Commons
Z W Chen,

Xinhua Chang,

Qianyu Ye

et al.

Clinical Kidney Journal, Journal Year: 2024, Volume and Issue: 17(8)

Published: Aug. 1, 2024

Kidney transplantation is an effective way to improve the condition of patients with end-stage renal disease. However, maintaining long-term graft function and improving patient survival remain a key challenge after kidney transplantation. Dysbiosis intestinal flora has been reported be associated complications in transplant recipients. The commensal microbiota plays important role immunomodulation recipient responses. several processes, such as use perioperative antibiotics high-dose immunosuppressants recipients, can lead gut dysbiosis disrupt interaction between host immune responses, which turn infection rejection organ In this review, we summarize discuss changes their influencing factors well evidence related impact on prognosis from

Language: Английский

Citations

2
Endocrine-Disrupting Chemicals, Hypothalamic Inflammation and Reproductive Outcomes: A Review of the Literature DOI Open Access

Galateia Stathori,

Kyriaki Hatziagapiou, George Mastorakos

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11344 - 11344

Published: Oct. 22, 2024

Endocrine-disrupting chemicals (EDCs) are environmental and industrial agents that interfere with hormonal functions. EDC exposure is linked to various endocrine diseases, especially in reproduction, although the mechanisms remain unclear effects vary among individuals. Neuroinflammation, particularly hypothalamic inflammation, an emerging research area implications for endocrine-related diseases like obesity. The hypothalamus plays a crucial role regulating its inflammation can adversely affect reproductive health. EDCs cross blood-brain barrier, potentially causing disrupting axis. This review examines existing literature on EDC-mediated inflammation. Our findings suggest 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD), polychlorinated biphenyl (PCB), tributyltin (TBT), phthalates, bisphenol A (BPA), chlorpyrifos (CPF) animals specifically affecting centers of gonadotropic To our knowledge, this first comprehensive topic, indicating as possible mediator between dysfunction. Further human studies needed develop effective prevention treatment strategies against exposure.

Language: Английский

Citations

2
Mitigating effect of Bifidobacterium longum CCFM1077 on nonylphenol toxicity: An integrative in vitro and in vivo analysis DOI
Zi Ye, Leilei Yu, Dezhi Lu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136401 - 136401

Published: Nov. 5, 2024

Language: Английский

Citations

1
Structural Racism and Adverse Pregnancy Outcomes Through the Lens of the Maternal Microbiome DOI Creative Commons
Megan Hadley,

Akosua Y. Oppong,

Jenell S. Coleman

et al.

Obstetrics and Gynecology, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 7, 2023

Microbiome science offers a glimpse into personalized medicine by characterizing health and disease states according to an individual's microbial signatures. Without critical examination of the use race as variable, microbiome studies may be susceptible same pitfalls other areas grounded in racist biology. We will examine biological variable pregnancy-related research. Emerging data from that investigate intestinal pregnancy suggest strong influence poor diet on adverse outcomes. Differences vaginal implicated outcomes are frequently attributed race. review evidence links systemic racism outcome differences with focus microbiomes well diet. also how structural ultimately contributes inequitable access healthy food higher risk environmental exposures among pregnant people lower socioeconomic status exacerbates common comorbidities.

Language: Английский

Citations

2
BISFENOL A: UMA AMEAÇA AOS HORMÔNIOS SEXUAIS DOI Open Access

Sara Catarina Pereira,

Vanessa Staldoni de Oliveira, Rúben Moreira

et al.

Editora Reflexão Acadêmica eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 70 - 92

Published: March 15, 2024

Masters, 16 PhD, 12 pos-doc and more than 66 undergraduate students with CNPq fellowship for Scientific Initiation.As research experience, develop studies in Pharmacy related to Pharmacognosy Medicinal Chemistry.Studies are focused on effect mechanism of action hormones, natural synthetic compounds toxicants diabetes male reproduction fertility.

Language: Английский

Citations

0
BISFENOL A: UMA AMEAÇA AOS HORMÔNIOS SEXUAIS DOI Open Access
Hemily Batista-Silva, Fátima Regina Mena Barreto Silva

Editora Reflexão Acadêmica eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 54 - 69

Published: March 15, 2024

Masters, 16 PhD, 12 pos-doc and more than 66 undergraduate students with CNPq fellowship for Scientific Initiation.As research experience, develop studies in Pharmacy related to Pharmacognosy Medicinal Chemistry.Studies are focused on effect mechanism of action hormones, natural synthetic compounds toxicants diabetes male reproduction fertility.

Language: Английский

Citations

0