Indus journal of bioscience research.,
Journal Year:
2025,
Volume and Issue:
3(3), P. 19 - 35
Published: March 14, 2025
Microplastics,
which
are
small
plastic
particles
less
than
5
millimeters
in
size,
originate
from
the
degradation
of
larger
items
or
intentionally
manufactured
for
various
uses.
These
have
become
ubiquitous
marine
and
freshwater
environments,
posing
significant
risks
to
aquatic
life
due
their
ability
absorb
concentrate
hazardous
pollutants.
The
exposure
Microplastics
(MPs),
leads
DNA
damage
fish
that
alters
hematological
parameters
causes
oxidative
stress,
thereby
impacting
overall
health
organisms.
MPs
also
induce
an
imbalance
reactive
oxygen
species
(ROS)
production
antioxidant
capacity,
causing
damage.
In
addition,
impact
immune
responses
physical
chemical
toxicity
cause
neurotoxicity,
altering
AchE
activity.
This
review
highlights
toxic
effects
through
indicators
were
examined
including
bioaccumulation,
parameters,
responses,
neurotoxicity
relation
MP
exposure,
facilitating
identification
biomarkers
following
fish.
study
digestive
tract
contains
more
microplastics
(MPs)
gills,
with
fragments,
fibers,
films,
pellets
being
predominant
types.
FTIR
analysis
identified
polyethylene,
polystyrene,
polyvinylchloride,
polyamide,
polycarbonate
both
gills
system.
pollution
triggered
stress
gambusia
East
Java
Brantas
River.
While
PVC-MPs
did
not
significantly
affect
gill
histopathology
ion
regulation,
combined
Cu
individual
findings
emphasize
need
further
research
on
heavy
metals
ecosystems.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(5), P. 579 - 579
Published: May 8, 2024
Microplastics
(MPs)
are
plastic
particles
between
0.1
and
5000
µm
in
size
that
have
attracted
considerable
attention
from
the
scientific
community
general
public,
as
they
threaten
environment.
contribute
to
various
harmful
effects,
including
lipid
peroxidation,
DNA
damage,
activation
of
mitogen-activated
protein
kinase
pathways,
cell
membrane
breakages,
mitochondrial
dysfunction,
lysosomal
defects,
inflammation,
apoptosis.
They
affect
cells,
tissues,
organs,
overall
health,
potentially
contributing
conditions
like
cancer
cardiovascular
disease.
pose
a
significant
danger
due
their
widespread
occurrence
food.
In
recent
years,
information
has
emerged
indicating
MPs
can
cause
oxidative
stress
(OS),
known
factor
accelerating
aging
organisms.
This
comprehensive
evaluation
exposed
notable
variability
reported
connection
OS.
work
aims
provide
critical
review
whether
harmfulness
constitute
environmental
contaminants
may
result
OS
through
analysis
research
existing
literature,
well
an
assessment
characteristics
causing
Additionally,
article
covers
analytical
methodology
used
this
field.
The
conclusions
point
necessity
for
further
into
effects
on
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 3, 2024
Abstract
In
recent
years,
the
environmental
health
issue
of
microplastics
has
aroused
an
increasingly
significant
concern.
Some
studies
suggested
that
exposure
to
polystyrene
(PS-MPs)
may
lead
renal
inflammation
and
oxidative
stress
in
animals.
However,
little
is
known
about
essential
effects
PS-MPs
with
high-fat
diet
(HFD)
on
development
microenvironment.
this
study,
we
provided
single-cell
transcriptomic
landscape
kidney
microenvironment
induced
by
HFD
mouse
models
unbiased
RNA
sequencing
(scRNA-seq).
The
injury
cell
atlases
mice
were
evaluated
after
continued
exposure,
or
treated
for
35
days.
Results
showed
plus
treatment
aggravated
profibrotic
microenvironment,
reshaping
cellular
components.
First,
found
acted
extracellular
matrix
organization
epithelial
cells,
specifically
proximal
distal
convoluted
tubule
inhibit
induce
ROS-driven
carcinogenesis.
Second,
activated
PI3K-Akt,
MAPK,
IL-17
signaling
pathways
endothelial
cells.
Besides,
markedly
increased
proportions
CD8
+
effector
T
cells
proliferating
Notably,
mononuclear
phagocytes
exhibited
substantial
remodeling
enriched
phosphorylation
chemical
carcinogenesis
treatment,
typified
alterations
tissue-resident
M2-like
PF4
macrophages.
Multispectral
immunofluorescence
immunohistochemistry
identified
macrophages
clear
carcinoma
(ccRCC)
adjacent
normal
tissues,
indicating
activate
might
regulate
pro-tumorigenic
injury.
conclusion,
study
first
systematically
revealed
molecular
variation
immune
scRNA-seq
approach,
which
a
basis
decoding
genitourinary
understanding
their
potential
mammals.
Graphical
Lubricants,
Journal Year:
2024,
Volume and Issue:
12(4), P. 114 - 114
Published: March 29, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS),
also
known
as
forever
chemicals,
exhibit
exceptional
chemical
stability
resistance
to
environmental
degradation
thanks
their
strong
C-F
bonds
nonpolar
nature.
However,
widespread
use
persistence
have
a
devastating
impact
on
the
environment.
This
review
examines
roles
of
PFAS
in
tribological
applications,
specifically
lubricants
lubricating
systems.
article
focuses
conventional
advanced
lubricants,
including
ionic
liquids
(ILs)
modern
automotive
vehicles.
The
objective
this
paper
is
provide
comprehensive
overview
adverse
impacts
whilst
acknowledging
outstanding
performance
surface
coatings,
composite
materials,
additives
oils
greases.
pathways
through
which
are
introduced
into
environment
via
systems
such
seals
O-rings
identified,
alongside
subsequent
dispersion
routes
interfaces
across
they
interact.
Furthermore,
we
examine
toxicological
implications
exposure
terrestrial
aquatic
life
forms,
plants,
animals,
humans,
along
with
ecological
consequences
bioaccumulation
biomagnification
trophic
levels
ecosystems.
ends
potential
remediation
strategies
for
use,
treatment
technologies,
biodegradation,
recovery
recycling
methods,
search
more
environmentally
benign
alternatives.
